Liberate Physician Center - Southwest Florida

03/20/2026

Cannabis Compounds CBD and CBG May Help Treat Fatty Liver Disease Affecting One-Third of Adults Worldwide

Recent research indicates that certain non-psychoactive compounds from the cannabis plant show promising potential in addressing fatty liver disease, also known as metabolic dysfunction-associated steatotic liver disease (MASLD).

This condition, affecting a large portion of adults worldwide, involves excessive fat accumulation in the liver, often linked to obesity, insulin resistance, and metabolic issues, with limited approved treatments beyond lifestyle changes.

The key compounds investigated are cannabidiol (CBD) and cannabigerol (CBG), both lacking the intoxicating effects of THC.

In preclinical experiments using obese mice fed high-fat diets to induce liver fat buildup, treatment with these compounds over four weeks significantly reduced hepatic triglycerides (liver fat), normalized blood lipid profiles, and improved glycemic control by enhancing insulin sensitivity and glucose clearance.

CBG demonstrated particularly strong effects, more robustly lowering body fat mass, "bad" LDL cholesterol, and overall metabolic markers compared to CBD. The beneficial outcomes appear to stem from mechanisms independent of classical cannabinoid receptors.

Instead, the compounds promote metabolic remodeling in the liver, boosting phosphocreatine-based energy buffering as a backup system and restoring lysosomal function for better cellular cleanup and waste removal.

This dual action helps the liver better handle lipids, reduce harmful accumulation, and combat inflammation and oxidative stress tied to disease progression.

While these findings highlight CBD and CBG as exciting, plant-derived candidates for future therapies, the evidence remains preclinical—primarily from animal models—and human clinical trials are still needed to confirm safety, optimal dosing, efficacy, and long-term impacts in people.

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A Potential New Plant Based Treatment Path

Although the results are promising, the researchers emphasize that further studies are needed to determine how these findings may translate to human treatments. Additional research will help clarify whether these compounds could eventually be developed into therapies.

Still, the study highlights an emerging direction in metabolic disease research. By targeting how cells store energy and clear waste, plant derived compounds such as CBD and CBG may open new possibilities for treating fatty liver disease and related metabolic disorders.

Links:
https://lnkd.in/gpD2cnva

https://lnkd.in/gt6sD9Hj

https://lnkd.in/g7WN3anX

Source: Hebrew University of Jerusalem, British Journal of Pharmacology

03/18/2026

Chronic back pain is one of those conditions that settles in and shapes a patient’s life from the moment they wake up. Muscles clamp down, nerves stay irritated, and inflammation becomes the background noise the body cannot quite turn off.

When cannabinoids step in for this type of pain, they are not acting as simple painkillers. They are helping the ECS, our Master Regulator, regain control over the signaling loops that drive persistent discomfort.

A clear example comes from the study "Cannabinoid Receptor Agonists and Antagonists as Analgesics" (2020), which showed how cannabinoids influence pain transmission through both the CB1 and CB2 pathways. That work helped clarify why THC shifts the perception of pain while CBD, CBGa, and CBDa influence the chemical landscape that keeps nerves inflamed.

THC helps turn down the volume on those amplified nerve messages that travel from irritated spinal tissue to the brain. CBD and CBGa help the body regulate inflammatory processes that wrap tightly around the spine and create muscle guarding. When those tissues settle down, the nerves stop firing the same distress signal on a loop.

CBDa supports this from another angle by influencing inflammatory pathways that run through the soft tissues and joint structures of the back. The acids give the Master Regulator room to reorganize the pain response so the body stops chasing itself in circles.

Mobility improves, tension drops, and the patient feels a return of internal steadiness instead of the familiar burn that pushes them into fatigue.

Every patient is different. Some rely on THC for function, while others stabilize with morning CBGa. What matters is that cannabinoids give the Master Regulator the tools it needs to reshape how pain signals flow.

When the system can do its job, the relief feels natural, not forced, and chronic back pain loses the grip it held for far too long.

Credit-Mike Robinson, Founder Global Cannabinoid Research Center (GCRC)

03/12/2026

🧠 Why is cannabis overdose considered extremely unlikely?

The answer lies in the brain.

The brainstem, which controls breathing and cardiovascular function, contains very few CB1 cannabinoid receptors. Because cannabinoids interact primarily with these receptors, they do not significantly suppress respiration.

In contrast, opioids act on receptors that are highly concentrated in the brainstem, which is why opioid overdose can stop breathing.

🌿 This difference in receptor distribution is a key reason why fatal overdose from cannabis alone has not been documented in scientific literature.
Understanding the endocannabinoid system helps clinicians better evaluate both the safety and therapeutic potential of cannabinoids.

03/06/2026

Need to research this... sounds promising!

Breakthrough research shows cannabis compounds like THC can clear toxic proteins linked to Alzheimer's disease from brain cells.

Researchers at the Salk Institute and Scripps Research Institute have identified compelling evidence that tetrahydrocannabinol (THC) and other cannabinoids can target the root causes of Alzheimer's disease. Laboratory tests on human nerve cells revealed that these compounds help remove amyloid-beta, a toxic protein that forms plaques and triggers damaging brain inflammation. By activating the body’s natural endocannabinoid system, these substances not only promoted the clearance of these harmful proteins but also inhibited the enzymes responsible for plaque production, effectively slowing the cellular damage associated with the disease.

While these findings highlight a significant neuroprotective potential for combined THC and CBD therapies, experts emphasize that the research is still in preliminary stages. Most successes have occurred within controlled laboratory environments and animal models, and rigorous human clinical trials are required to determine if these results translate to real-world medical benefits. Currently, there is no evidence that cannabis can cure or reverse dementia, but this exploratory work provides a vital roadmap for developing future treatments aimed at protecting the brain from inflammatory decay.

source: Salk Institute for Biological Studies. Cannabinoids remove plaque-forming Alzheimer's proteins from nerve cells. Nature: Aging and Mechanisms of Disease.

02/24/2026

Cannabis and legalization initiative.

A Florida campaign seeking to put ma*****na legalization on the ballot is facing another complication as it continues to litigate the status of its 2026 signature drive. Under a new election law, the hundreds of thousands of signatures activists already collected for this year will not be carried ov...

02/19/2026

shatters misconceptions and misconceptions: protects and develops the brain, and longtime older users have better cognitive abilities than peers who don't!!!

The results of the Danish study:
"Men with a history of cannabis use experienced SMALLER cognitive decline from early adulthood to late middle age compared to men without a history of cannabism use." Among cannabis users, neither the age of cannabis initial use nor frequent use were significantly associated with aging-related cognitive decline. ”

Discussion and conclusions:
“In a sample of more than 5,000 men monitored for an average of 44 years, we did not find significant adverse effects of cannabis use on aging-related cognitive decline. ”

A large Danish cohort study examined whether long-term exposure to cannabis was associated with permanent cognitive decline. Researchers analyzed data from 5,162 men born between 1949. in 1961. years, comparing the results of intelligence tests taken in early adulthood with subsequent assessments decades later.

The results did not show a greater long-term cognitive decline among participants who reported use compared to a group of those who did not use. In fact, the average group difference was small, about 1.3 IQ points, and slightly favored those with reported long-term cannabis use! Researchers noted that the study relied on male-only research data.

Scientists have stressed that observational studies cannot prove cause and effect. Socio-economic background, education, lifestyle factors, and general health can influence long-term cognitive outcomes.

Other surveys from Australia and the United States have shown similar findings, although experts continue to call for broader studies involving women and diverse populations.

Danish findings contribute to the ongoing scientific discussion about long-term brain health and controlled exposure to Cannabis, emphasizing the importance of data over assumptions.

1. Danish study from 2024 : https://lnkd.in/gyzwXZsX

2. A study of US universities in Colorado and Georgia: https://lnkd.in/gZ5D-jPm

A US research team found that cannabis use in the elderly is generally associated with higher volumes in several regions of the brain and better cognitive function in adults between 40 and 77 years old.

Key findings:

The study found greater brain volumes and improved cognitive function in middle and older adults who used cannabis, particularly in moderate use cases.

Areas of the brain studied include learning and memory, processing speed, attention and executive functions, which are traditionally thought to be in contrast with cannabis consumption.

News source:
https://lnkd.in/g9nd_Pe6

https://lnkd.in/g28CCPT2

02/17/2026

Sen. Carlos Guillermo Smith introduces legislation to legalize cannabis for adults in the state.

Sen. Carlos Guillermo Smith introduces legislation to legalize cannabis for adults in the state.

02/17/2026

Cannabis and Veterans

Florida senators have approved an amended bill to increase the amount of medical ma*****na a registered patient can buy and slash the fee for medical cannabis identification cards for military veterans. At a hearing before the Senate Health Policy Committee on Wednesday, members advanced the legisla...

02/14/2026

Cannabis and Shingles, A Natural Ally in Pain Relief ?
Chronic nerve pain and skin inflammation, as seen in shingles (herpes zoster), remain difficult to manage with conventional therapies alone.

This inspired me to explore a growing area of interest, the potential role of
Full-spectrum cannabis extracts in supporting symptom relief.

This detailed yet accessible report looks at how cannabinoids (like THCa, CBDa, CBD, THC), Terpenes, Flavonoids, and plant Sterols may work together through the so-called Entourage effect, to modulate pain, inflammation, itching, and skin repair.

It’s written for a broad audience, patients, clinicians, health innovators, and anyone with a passion for plant-based medicine and integrative care.

The report blends scientific insight with practical observations and patient perspectives, in a format that’s informative but easy to follow.

Download or read the full PDF below.

Note: Green-highlighted text in the document contains clickable links to supporting research and references.

I welcome your thoughts, input, or shared experiences.

Peter Vermeul
https://lnkd.in/e4ksJAwU

02/02/2026

Florida and recreational ma*****na

A proposed amendment to Florida’s constitution that would have allowed recreational ma*****na use for adults failed to qualify for the 2026 ballot.

01/27/2026

Cannabis Compounds Kill Deadly Fungal Infections Better Than Current Drugs—Scientists Are Shocked. Scientists say it may be the key to beating deadly fungal infections.

“Two compounds found in cannabis—cannabidiol (CBD) and cannabidivarin (CBDV)—have demonstrated potent antifungal properties in a breakthrough study from Macquarie University.
Researchers discovered that these non-psychoactive and mildly psychoactive compounds effectively killed Cryptococcus neoformans, a lethal fungus responsible for life-threatening meningitis. In lab tests, CBD and CBDV acted even faster than standard antifungal medications, disrupting fungal membranes and metabolic pathways.

The compounds also eliminated common skin fungi, such as those that cause athlete's foot and jock itch.

To explore real-world potential, scientists used moth larvae with immune systems similar to mammals. When infected larvae were treated topically with CBD, their survival rate nearly matched that of uninfected controls—outperforming current gold-standard antifungal treatments.

While more research is needed before human use, especially for internal infections, the study paves the way for CBD-based topicals to combat skin fungal infections.

With drug resistance on the rise and fungal infections becoming increasingly difficult to treat, cannabis compounds could offer a timely and natural new defense. Current antifungal drugs are losing effectiveness as fungi evolve resistance, making the search for alternative treatments urgent.

This discovery reveals yet another medical application hidden inside the cannabis plant—one that could save lives as drug-resistant infections spread globally.

Reference: Macquarie University study on cannabis compounds and antifungal properties - "CBD and CBDV antifungal efficacy"

Article written by Jamie Novotny

01/08/2026

A new Florida bill would impose open container restrictions on medical ma*****na patients and h**p product consumers driving with cannabis in their cars.