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12/18/2019

Columbia and Yale scientists found the spiritual part of our brains—religion not required
By Ephrat Livni

Scientists seek to quantify everything—even the ineffable. And so the human search for meaning recently took a physical turn as Columbia and Yale University researchers isolated the place in our brains that processes spiritual experiences. In a new study, published in Cerebral Cortex (paywall) on May 29, neuroscientists explain how they generated “personally relevant” spiritual experiences in a diverse group of subjects and scanned their brains while these experiences were happening. The results indicate that there is a “neurobiological home” for spirituality. When we feel a sense of connection with something greater than the self—whether transcendence involves communion with God, nature, or humanity—a certain part of the brain appears to activate.

The study suggests that there is universal, cognitive basis for spirituality, as opposed to a cultural grounding for such states. This new discovery, researchers say, could help improve mental health treatment down the line. Previous studies have examined the brain activity of Buddhist monks or Catholic nuns, say—people who are already spiritually inclined and familiar with the practice of cultivating transcendent states. But this research analyzed subjects from different backgrounds with varying degrees of religiosity, and totally different individual notions of what constitutes a spiritual experience. “Although studies have linked specific brain measures to aspects of spirituality, none have sought to directly examine spiritual experiences, particularly when using a broader, modern definition of spirituality that may be independent of religiousness,” the study explains.

Because there are many types of transcendent moments with varying degrees of meaning to different people, it’s been difficult to test the general effects of spirituality, as opposed to religiosity. So for this study, the researchers generated individual scripts that put each subject in their own relevant transcendent state. With each of the 27 subjects—all healthy young adults—the researchers created a personal script based on each person’s self-reported previous spiritual experiences. The scientists then scanned brain activity when generating such a state in the subjects. During their varied transcendent states, all subjects showed similar activity patterns in the parietal cortex, which processes sensation, spatial orientation, and language, and is thought to influence attention, among other functions. In other words, whether the thing that makes a person feel connected to something greater involves church, trees, or a stadium full of sports fans, it appears to have the same effect on the brain.

The effect on the brain is distinct from the effect of other forms of relaxation, according to researchers. “We observed in the spiritual condition, as compared with the neutral-relaxing condition, reduced activity in the left inferior parietal lobule (IPL), a result that suggests the IPL may contribute importantly to perceptual processing and self-other representations during spiritual experiences,” the study explains. These changes in the brain may help explain why, during spiritual experiences, the barrier between the self and others can be reduced or even eliminated altogether. Although we need some separation between ourselves and everyone else for protection and to manage reality, removing the barrier every so often is also valuable. “Spiritual experiences are robust states that may have profound impacts on people’s lives,” explains Yale psychiatry and neuroscience professor Marc Potenza, in a statement about the work. “Understanding the neural bases of spiritual experiences may help us better understand their roles in resilience and recovery from mental health and addictive disorders.”

Spiritual experiences involve “pronounced shifts in perception [that] buffer the effects of stress,” the study says. The findings suggest that those experiences can be accessed by everyone, and that transcendence isn’t dependent upon religiosity. That makes studying spiritual experiences and figuring out how to use such states for improved mental health easier for scientists. Next, the researchers hope to test a bigger group of subjects of all ages. Beyond mental health, scientists study spirituality because the human quest for meaning is timeless and universal. By cultivating spiritual experiences in addition to strengthening our intellectual abilities, people can lead emotionally richer lives and develop more open minds, scientists say.

As Tony Jack, director of the Brain, Mind and Consciousness lab at Case Western Reserve University—who was not involved in this study—explains to WKSU, analytical thinking and spiritual, empathic thinking rely on different neural pathways and processes. They don’t happen simultaneously in the brain, but both modes are necessary, like breathing in and breathing out. “You can’t do both at the same time, but you need both to stay healthy and well,” he says. Sign up for the Quartz Daily Brief email Sign me up Stay updated about Quartz products and events. science, culture, religion, mental health, Nature 💬+ Add your insights Read This Next Scientists studying psychoactive drugs accidentally proved the self is an illusion February 9, 2018Quartz Recommended stories SHORTCUTS The best brain hack for learning faster is one you already know Quartz THE PLASTIC MIND Here’s why Elizabeth Koch, the daughter of a GOP megadonor, chose science over politics Quartz Sponsor Content By Microsoft This is how AI understands human language (and chats back) Quartz DOG & DOLPHIN PSYCHOLOGY

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https://health-pub.com/Study reveals rapid increases in cannabis use among individuals with depression11-Dec-2019 10:05...
12/18/2019

https://health-pub.com/

Study reveals rapid increases in cannabis use among individuals with depression
11-Dec-2019 10:05 AM EST

Columbia University, Mailman School of Public Health

Newswise — December 11, 2019 -- Results of a new study suggest that over the past decade (2005-2017), the prevalence of cannabis use in the United States has increased among persons with and without depression, though the increase is significantly more rapid among those with depression. At the same time, the perception of risks associated with cannabis use have declined overall, and the decline has been more rapid among those with depression. The findings, which are published in Addiction, come from a survey-based study of 728,691 persons aged 12 years or older.

In 2017, cannabis use was approximately twice as common among those with depression. Perception of risks associated with cannabis use has appeared to act as a barrier to cannabis use in the general population.

"The prevalence of cannabis use among those with depression who perceived no risk associated with regular use was much higher than among those who perceived significant risk associated with use -- 39 percent versus 1.6 percent, respectively," said corresponding author Renee Goodwin, PhD, of Columbia University Mailman School of Public Health and The City University of New York. "With increasing legalization in the U.S., previous studies have shown that perception of risk associated with use is declining overall. The results of this study show that this decline is even more rapid among this vulnerable population: those with depression."

In 2017, the prevalence of past month cannabis use was 19 percent among those with depression and 9 percent among those without depression. Daily cannabis use was common among 7 percent of those with depression and among 3 percent of those without it.

Certain groups appeared more vulnerable to use. For instance, nearly one third of young adults (30 percent) aged 18 to 25 with depression reported past 30-day use. "As brain development is ongoing until at least age 25, and young persons with depression are especially vulnerable, this is a group who may need attention in terms of prevention and intervention," noted Goodwin.

"Depression is not generally a condition for which medicinal cannabis is prescribed, and it is not clear why recreational use would occur disproportionately among those with depression," observed Goodwin. "It is conceivable that cannabis may be increasingly used in an attempt to self-medicate depression in states where it is legal for recreational use."

# # #

The study was supported by the National Institute on Drug Abuse (grants K01DA043413 and R01DA02892).

Columbia University Mailman School of Public Health

Founded in 1922, the Columbia University Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Columbia Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 450 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,300 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Columbia Mailman School is also home to numerous world-renowned research centers, including ICAP and the Center for Infection and Immunity. For more information, please visit http://www.mailman.columbia.edu.

Dec 10th Tuesday 2:00 pm - 4:30 pm Growing Up Positive: A Special World AIDS Day Event Join ICAP at Columbia University for a short film screening, panel discussion, and photo gallery opening, highlighting the trials and triumphs of adolescents living with HIV

Mom's Diabetes May Impair Development of Baby's KidneysExposure to type 1 diabetes in the womb led to fewer nephrons in ...
11/02/2019

Mom's Diabetes May Impair Development of Baby's Kidneys
Exposure to type 1 diabetes in the womb led to fewer nephrons in offspring
1-Nov-2019 2:00 PM EDT
American Physiological Society (APS)
Article title: In utero exposure to maternal diabetes impairs nephron progenitor differentiation.
Authors: Debora M. Cerqueira, Shelby Lynn Hemker, Andrew J. Bodnar, Daniella M. Ortiz, Favour O. Oladipupo, Elina Mukherjee, Zhenwei Gong, Corynn Appolonia, Radhika H. Muzumdar, Sunder Sims-Lucas, Jacqueline Ho
From the authors: “Our data from this model of maternal diabetes suggest impairment in the differentiation of nephron progenitors into renal vesicles, resulting in an overall decrease in nephron number.”
This study is highlighted as one of November's "best of the best" as part of the American Physiological Society's APSselect program.
The incidence of diabetes mellitus has significantly increased among women of childbearing age and it has been shown that prenatal exposure to maternal diabetes increases the risk of associated congenital anomalies of the kidney. Congenital anomalies of the kidney are amongst the leading causes of chronic kidney disease in children. To better understand the effect of maternal diabetes on kidney development, we analyzed wildtype offspring (DM_Exp) of diabetic Ins2+/C96Ymice (Akitamice). DM_Exp mice at postnatal day 34 (P34) have a reduction of approximately 20% in the total nephron number compared to controls, using the gold-standard physical dissector/fractionator method. At the molecular level, the expression of the nephron progenitor markers Six2 and Cited1was increased in DM_Exp kidneys at postnatal day 2 (P2). Conversely, the number of early developing nephrons was diminished in DM_Exp kidneys. This was associated with decreased expression of the intracellular domain of Notch1 (NICD1) and the canonical Wnt target lymphoid enhancer binding factor 1 (Lef1). Together, these data suggest that the diabetic intrauterine environmentimpairs the differentiation of nephron progenitors into nephrons, possibly by perturbing the Notch and Wnt/b-catenin signaling pathways.

https://www.health-pub.com/new-blog
04/29/2019

https://www.health-pub.com/new-blog

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https://www.health-pub.com/antiaging-tips
04/28/2019

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