
09/09/2025
A natural plant virus that doesn’t infect humans is helping the body fight cancer. Yes, really.
A virus that infects black-eyed peas is showing remarkable promise as a cancer-fighting tool—and it doesn’t make humans sick.
Scientists at the University of California San Diego have discovered that the cowpea mosaic virus (CPMV) can awaken the human immune system to target and destroy cancer cells.
Though harmless to humans, CPMV triggers a robust response from both innate and adaptive immune systems, training the body not just to eliminate tumors, but also to recognize and attack cancer elsewhere. When injected directly into tumors in lab studies on mice and dogs, the virus mobilized key immune players like macrophages, B cells, and T cells, with lasting anti-cancer effects.
Unlike other similar plant viruses, CPMV uniquely stimulates a cascade of interferons—proteins long known for their cancer-fighting abilities—and activates key immune pathways inside human cells. It’s also cheap and scalable, grown in plants with nothing more than sunlight, soil, and water.
This breakthrough not only offers hope for a more accessible form of immunotherapy, but also helps researchers better understand what makes an immune system strike back. With clinical trials on the horizon, CPMV may soon redefine how we use biology—and even plants—in the battle against cancer.
Source: Omole, A. O., Newton, H. S., Cedrone, E., Nematpour, K., Xie, S., Zhao, Y., Tran, B., Dobrovolskaia, M. A., & Steinmetz, N. F. (2025). Comparative analyses for plant virus-based cancer immunotherapy drug development. Cell Biomaterials, 22 May 2025.