10/23/2025
Whatâs wrong with this picture? đ
Is the current medical âstandard of careâ for joint pain and degeneration silently destroying your joints - speeding your need for surgery?
Based on current published research, the answer appears to be YES!
Although NSAIDs, Steroid Injection, and even PRP injections may provide short term relief, the research is clear that they accelerate cartilage breakdown and joint degeneration.
Thatâs why at Regenerative Medicine of Raynham, we take a different approach.
𦵠Your body has the ability to repair itself when given what it needs.
I will always give you my best recommendation to speed your recovery with advanced cutting- edge technologies. However, here are some natural substances you can obtain on your own which may help repair your joints without causing further joint destruction:
1) Tumeric/Curcumin
2) Resveratrol
3) Omega 3 fatty acid
4) Ginger
5) Specific Flavonoids
6) Vitamin C
Here are a couple of joint ointments that have been shown to reduce pain and inflammation.
1) Capsaicin cream
2) CBD ointments
(check with your doctor or pharmacist to make sure you will not react to any of these negatively)
Why donât we take a different approach and give the body what it needs to repair itself?
NSAIDs
⢠Fujii K, Tajiri K, Sai S, Tanaka T, Murota K. Effects of nonsteroidal antiinflammatory drugs on collagen biosynthesis of cultured chondrocytes. Semin Arthritis Rheum. 1989;18(3 Suppl 1):16-18.
** https://pubmed.ncbi.nlm.nih.gov/2734619
⢠Fujii K, Tajiri K, Kajiwara T, Tanaka T, Murota K. Effects of NSAID on collagen and proteoglycan synthesis of cultured chondrocytes. J Rheumatol Suppl. 1989 Aug:18:28-31.
** https://pubmed.ncbi.nlm.nih.gov/2810293
Systemic steroids / Glucocorticoids
⢠Miyazaki Y, Tsukazaki T, Hirota Y, et al. Dexamethasone inhibition of TGF-βâinduced cell growth and type II collagen mRNA expression through ERK-integrated AP-1 activity in cultured rat articular chondrocytes. Osteoarthritis Cartilage. 2000;8(5):378-385.
**https://pubmed.ncbi.nlm.nih.gov/10966845
⢠James CG, Appleton CTG, Ulici V, Underhill TM, Beier F. Expression profiling of dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development. BMC Genomics. 2007;8:205.
**https://bmcgenomics.biomedcentral.com/.../1471-2164-8-205
⢠Hartmann K, et al. Molecular actions of glucocorticoids in cartilage and bone. Physiol Rev. 2016;96(2):409-447.
Cortisone / Intra-articular corticosteroid injections
⢠McAlindon TE, LaValley MP, Harvey WF, et al. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2017;317(19):1967-1975.
**https://pubmed.ncbi.nlm.nih.gov/28510679
⢠(PMC full text) Effect of Intra-articular Triamcinolone vs Saline⌠**https://pmc.ncbi.nlm.nih.gov/articles/PMC5815012
⢠Klocke R, et al. Cartilage turnover and intra-articular corticosteroid injections: overview & biomarker effects. Clin Rheumatol. 2018;37(5):1383-1393.
⢠Guermazi A, et al. Debate: intra-articular steroid injections for OAâconcerns around cartilage loss after repeat injections. (Review) Osteoarthritis Imaging. 2023.
Standard Prepared PRP
⢠Sundman EA, Cole BJ, Fortier LA. Platelet-rich plasma modulates synoviocyte and cartilage cell mediators: formulation-dependent inflammatory effects. Am J Sports Med. 2014;42(12):3120-3129.
**https://pubmed.ncbi.nlm.nih.gov/24192391
⢠Xu Z, Yin W, Zhang Y, et al. Comparative evaluation of leukocyte-rich PRP vs pure PRP: NF-κB activation and inferior cartilage repair with L-PRP. Sci Rep. 2017;7:43301.
**https://www.nature.com/articles/srep43301
⢠Braun HJ, et al. Effect of PRP formulations and blood products on human synoviocytesâLR-PRP and RBCs increase inflammatory cytokines/proteases. Am J Sports Med. 2014;42(12):3028-3037.
⢠Gupta A, et al. Red Blood Cells in PRP: avoid if possibleâRBC exposure drives chondrocyte apoptosis/oxidative injury. Arthrosc Sports Med Rehabil. 2023;5(5):e1189-e1201. **https://pmc.ncbi.nlm.nih.gov/articles/PMC10525813
⢠Lee AJ, et al. Red blood cell exposure increases chondrocyte susceptibility to oxidative stress following hemarthrosis. Osteoarthritis Cartilage. 2023;31(10):1365-1376. **https://pubmed.ncbi.nlm.nih.gov/37364817