10/24/2025
New research coming out of the Pauley Heart Center shows that statins — a medication commonly used to treat high cholesterol—may provide some protection to breast and lymphoma cancer patients’ cognition during chemotherapy. In a recent study published in JAMA Network Open, lead author Pamela Jill Grizzard, MS, assistant director of research compliance and regulatory affairs at Pauley, found that patients who received statins before, during and up to 24 months after cancer treatment saw an improvement in their executive function, or mental skills for planning, focus and self-control.
“Cancer treatment can be debilitating, and cognitive decline arising from chemotherapy treatment can sometimes last long after treatment concludes,” Grizzard said. “My hope is that this research contributes in some small way to any larger efforts to offer therapeutic relief to cancer patients who encounter difficulties with executive function following cancer treatment. If future studies confirm a beneficial effect, statins could become a valuable tool in helping cancer survivors maintain cognitive function and quality of life throughout treatment.”
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