11/19/2025
Phenomenal news. Thanks to Scientific American for covering this development!
"Emerging research on the biology of postpartum depression shows that it is not like other severe mood disorders neurologically or biochemically. Rather it is a result of dramatic changes in hormone levels that come with pregnancy and childbirth. Studies have shown that levels of progesterone and a related hormone, allopregnanolone, rise significantly during pregnancy. Then the levels drop sharply after delivery. Some women are particularly sensitive to this drop, which can disrupt the brain circuitry that regulates mood, leaving them unable to effectively deal with the stresses of motherhood. Zuranolone is designed to offset that drop-off."
Deep emotional distress after birth kills many mothers. A new kind of drug offers better, faster treatment