02/26/2026
Our CuRe Trial just hit a new major milestone! The research team safely performed the world's first spina bifida treatment that combines fetal surgery with stem cells, offering new hope for children with the lifelong condition.
CuRe is the world’s first in-utero stem cell therapy for spina bifida, and the only trial aimed at improving the outcomes for the children over fetal surgery alone. The findings of phase 1 were just published in The Lancet.
“It paves the way for new treatment options for children with birth defects. The future is exciting for cell and gene therapy before birth," said Diana Farmer, the CuRe Trial’s principal investigator and chair of the UC Davis Department of Surgery.
Spina bifida affects 1,500 to 2,000 children in the United States every year. While fetal surgery has greatly improved outcomes since it was introduced more than a decade ago, many children still struggle with mobility and have other long-term complications. The CuRe Trial is exploring whether stem cells can add regenerative power to surgery, potentially improving mobility and quality of life.
Learn more about the findings: https://health.ucdavis.edu/news/headlines/first-ever-in-utero-stem-cell-therapy-for-fetal-spina-bifida-repair-is-safe-study-finds/2026/02
Image descriptions:
1: Diana Farmer, M.D. (right), Emily (left) are standing and looking at a baby in Diana's arms. Emily and Robbie were the first CuRe trial patients.
2: Jeff Maginnis (left) and Michelle Johnson (right) smile at each other while holding baby Tobi in the UC Davis NICU. Michelle and Tobi were the second CuRe trial patients.
3: Jared (left) and Lindsey (right) are walking with their son, Nixon, holding their hands. Lindsey and Nixon were the sixth CuRe trial patients.
4: Diana Farmer, M.D., during surgery is surrounded by medical professionals wearing blue surgical gowns and caps. Diana is in the middle and has a blue surgical cap that says "CuRe."