09/02/2022
I am often asked about supplements that help with depression. Here is my list:
🔸St. John’s wort. For mild to moderate depression, St. John’s wort is better than paroxetine 20 mg. Other trials show it is as effective as selective serotonin reuptake inhibitors, including fluoxetine, paroxetine, and sertraline, as well as tricyclic antidepressants, but with fewer side effects. However, since St. John’s wort causes many drug interactions, it might not be an appropriate choice for some patients, including those who take other conventional drugs.
Dose: For mild to moderate depression, most trials have used St. John’s wort extract standardized to 0.3 percent hypericin content, 300 mg 3x/day for up to six weeks.
🔸Omega-3 fatty acids. Low omega-3 levels are associated with depression.
Dose: 1.5 to 2 gms/day
🔸Low-dose lithium. Lithium has been used at standard doses for bipolar disorder dating back to 1870, but now trace and low doses have been found to be effective in depression, suicidal ideation, dementia, ADHD, and Parkinson’s disease. Lithium is a mood stabilizer and can be found in vegetables, mustard, kelp, thyme, pistachio nuts, and tap water.
Dose: 0.4 to 2 m/day for the long term helps some patients with depression.
🔸Rhodiola. Rhodiola decreases overall depressive symptoms, emotional instability, insomnia, and somatization in patients with mild to moderate depression, treated for six weeks. Compared to sertraline (Zoloft) in mild to moderate depression, rhodiola has a better benefit-to-risk profile.
Dose: 340 mg once or twice daily.
🔸Saffron. Based on six randomized trials, saffron effectively treats mild to moderate depression and appears to be as effective as the antidepressant imipramine.
Dose: 30 mg 1x/day for six or more weeks.
Other vitamins that may help be associated with reduced depression symptoms:
🔸Vitamin D. Dose: 600 to 2,000 IU/day, or enough to keep your serum vitamin D levels at 60 to 80.
🔸Vitamin B6. Dose: 50 to 100 mg per day of vitamin B6 or pyridoxine-5-phosphate (P5P).
🔸Folate. Dose: 200 mcg to 15 mg daily for up to six months.