04/23/2026
The transplant community continues to evaluate prone positioning as a strategy to improve donor lung preservation.
The ongoing PRODON-AR randomized trial is studying whether early prone positioning after neurologic death increases the number of lungs suitable for transplantation (Hospital de Alta Complejidad del Bicentenario Esteban Echeverría, 2025).
Additional clinical investigations such as the P-POD study are exploring whether donor pronation may improve post-transplant recipient outcomes.
As evidence grows, technologies that streamline prone therapy such as the Pronova-O2TM Automated Prone Therapy System may help centers adopt evidence-based donor optimization strategies safely.
References
Hospital de Alta Complejidad del Bicentenario Esteban Echeverría. (2025). Prone vs supine position in potential organ donors: PRODON-AR. ClinicalTrials.gov Identifier NCT07251777.
DelSorbo, L., et al. (2024). Prone positioning in neurologically deceased potential organ donors to improve donor lung function and transplant recipient outcomes (P-POD). ClinicalTrials.gov Identifier NCT06259357.