George Lab

06/18/2020

New paper from the lab validating an animal model of e-cigarette use in Neuropsychopharmacology: Lauren Smith and Marsida Kallupi show that rats will v**e ni****ne to the point of dependence, impacting their neuro-cardio-pulmonary systems.

The George Lab published a new study investigating electronic cigarette use. The main goal of the study was to validate a new pre-clinical model of ni****ne v***r self-administration with anatomical and behavioral characterization of dependence. We examined the effects of chronic ni****ne v***r inta...

06/18/2020

Another recent paper from Dr. Simpson reviewing the role of CRF in alcohol and ni****ne addiction.

Our newest review, “Role of CRF in Alcohol and Ni****ne Addiction” was recently published in a special collection on "The Role of Neuropeptides in Drug and Ethanol Abuse: Medication Targets for Drug and Alcohol Disorders", a collection assembled by guest editor, Dr. Jessica Barson, in the journa...

06/18/2020

Recent paper front the lab from Dr. Sierra Simpson, uncovering the role of the microbiome in the effect of opioids on the brain.

Substance use disorders are complex. Genetics, environment, and exposure all play a role in drug use. Recently, there has been evidence that another factor may play a role in substance use disorders: the gut-brain axis. The gut-brain axis is the bidirectional communication pathways between the gut m...

01/14/2020

The last paper of the week published by the lab provide the first brain map of alcohol dependence at single cell resolution in an animal model for the study of alcohol use disorder.

This new paper provide the first brain map of alcohol dependence at single cell resolution in an animal model of Alcohol use disorder. Employing advanced techn

01/14/2020

This new paper provide preclinical evidence that targeting the D3 receptors may provide efficacy in the treatment of opioid use disorder.

This paper provide preclinical evidence that targeting the D3 receptors may provide efficacy in the treatment of opioid use disorder.Using an animal model

01/14/2020

This new paper from the lab identify a neuropeptide that is acting in a key brain region responsible for opioid dependence and demonstrates that it is possible to reverse the motivation to use opioids in opioid-dependent rats.

This new paper identify a neuropeptide that is acting in a key brain region responsible for opioid dependence and demonstrates th

06/05/2019

If you are interested in using the Co***neBiobank or OxycodoneBiobank for your research but do not have dedicated funding, you can apply here to a Pilot G

02/11/2019

After 13 years at The Scripps Research Institute, I am excited to announce that the George Lab will be moving to the University of California San Diego this April!

After 13 years at The Scripps Research Institute, I am excited to announce that the George Lab will be moving to the University of California San Diego this Apr...

10/17/2018

An enzymatic approach for the treatment of ni****ne addiction. An interview with Drs. Kallupi and George
http://advances.sciencemag.org/content/4/10/eaat4751

https://www.newsweek.com/quit-smoking-enzyme-stops-ni****ne-addiction-rats-without-withdrawal-symptoms-1173914

The enzyme NicA2-J1 was found to reduce ni****ne levels in the blood, without leading to any withdrawal symptoms.

06/27/2018

Researchers discovered that by activating this brain receptor, alcohol-dependent rats decreased their alcohol intake.

01/09/2018

New paper published on a very exciting new line of research. What if we could completely block the effect of ni****ne to prevent dependence and relapse? Great work by Dr. Kallupi.

The George lab published a new study in collaboration with the Janda lab providing preclinical evidence that a newly engineered enzyme can degrade ni****ne in t...