GenLight Technologies Personalized Genomics Medicine

GenLight Technologies Personalized Genomics Medicine

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Remarkable progress in understanding genomics and epigenetics of stemness pathways highlights novel therapeutic targets for undruggable clinically lethal cancers and human brain disorders https://t.co/n7wcpXgIVh
Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of neurodegenerative, neurodevelopmental, & neuropsychiatric disorders https://t.co/n7wcpXgIVh
Sustained activity of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh
Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in a persisten failure of the homeostatic cycle of replenishment dying differentiated cells in human body. https://t.co/n7wcpXgIVh
In contrast to mutations-initiated/mutations-accumulating slowly progressing tumors, failures of epigenetic silencing of specific endogenous retroviral loci play a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh
Intrinsic propensity of stem cell like cancers to spread from the very early stages of tumor initiation and progression contributes to therapy resistance even if detected at the early stages. Cure of stem cell like cancers requires novel therapies.
https://t.co/n7wcpXgIVh
Stem cell like cancer cells are epigenetically wired to survive in blood & lymph, travel throughout the body, spread and seed metastatic tumors at distant organs. Treatment would require epigenetic interference & chromatin silencing recovery tools.
https://t.co/n7wcpXgIVh
Humans have 2 distinct types of cancers: 1.Curable if detected early mutations-accumulating slowly progressing tumors; 2.Therapy resistant clinically lethal stem cell like cancers due to loss of epigenetic silencing of specific retroviral loci. https://t.co/n7wcpXgIVh
Genomics & epigenetics of naive & primed states of hESC reveals a global role of defined retroviral elements in human diseases & identifies diagnostic & therapeutic targets for stem cell like clinically lethal cancers https://t.co/n7wcpXgIVh
Recent discoveries highlight limitations of a prevailing concept viewing all cancers as mutations-initiated/mutations-accumulating slowly progressing malignancies. https://t.co/n7wcpXgIVh
Humans have 2 distinct types of cancers: 1.Curable if detected early mutations-accumulating slowly progressing tumors; 2.Therapy resistant clinically lethal stem cell like cancers due to loss of epigenetic silencing of specific retroviral loci. https://t.co/n7wcpXgIVh

Stem cell like cancer cells are epigenetically wired to survive in blood & lymph, travel throughout the body, spread and seed metastatic tumors at distant organs. Treatment would require epigenetic interference & chromatin silencing recovery tools.
https://t.co/n7wcpXgIVh

Intrinsic propensity of stem cell like cancers to spread from the very early stages of tumor initiation and progression contributes to therapy resistance even if detected at the early stages. Cure of stem cell like cancers requires novel therapies.
https://t.co/n7wcpXgIVh

In contrast to mutations-initiated/mutations-accumulating slowly progressing tumors, failures of epigenetic silencing of specific endogenous retroviral loci play a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in a persisten failure of the homeostatic cycle of replenishment dying differentiated cells in human body. https://t.co/n7wcpXgIVh

Sustained activity of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of neurodegenerative, neurodevelopmental, & neuropsychiatric disorders https://t.co/n7wcpXgIVh

Genomics & epigenetics of naive & primed states of hESC reveals a global role of defined retroviral elements in human diseases & identifies diagnostic & therapeutic targets for stem cell like clinically lethal cancers https://t.co/n7wcpXgIVh
Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of neurodegenerative, neurodevelopmental, & neuropsychiatric disorders https://t.co/n7wcpXgIVh

Personalized genomics-guided precision medicine for therapy-resistant prostate and breast cancers (h Long-term genomics-guided health management.

Genomics-guided personalized disease prevention, target-tailored precision medicine (http://genlighttechnology.com). Personalized genomics-guided precision medicine for therapy-resistant prostate and breast cancers (http://genlighttechnology.com). Inflammation & autoimmune disorders. Prostate, breast, and colon cancer risk assessment, diagnostic, prognostic, and therapy-selection services (http://

Operating as usual

Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans -... 09/19/2022

Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans -...

Timelines of population-level effects of viruses on humans varied from the evolutionary scale of million years to contemporary spread of viral infections. Correspondingly, these events are exemplified by: (i) emergence of human endogenous retroviruses (HERVs) from ancient germline infections leading to stable integration of viral genomes into human chromosomes; and (ii) wide-spread viral infections reaching a global pandemic state such as the COVID-19 pandemic. Despite significant efforts, understanding of HERV's roles in governance of genomic regulatory networks, their impacts on primate evolution and development of human-specific physiological and pathological phenotypic traits remains limited. Remarkably, present analyses revealed that expression of a dominant majority of genes (1696 of 1944 genes; 87%) constituting high-confidence down-steam regulatory targets of defined HERV loci was significantly altered in cells infected with the SARS-CoV-2 coronavirus, a pathogen causing the global COVID-19 pandemic. This study focused on defined sub-sets of DNA sequences derived from HERVs that are expressed at specific stages of human preimplantation embryogenesis and exert regulatory actions essential for self-renewal and pluripotency. Evolutionary histories of LTR7/HERVH and LTR5_Hs/HERVK were charted based on evidence of the earliest presence and expansion of highly conserved (HC) LTR sequences. Sequence conservation analyses of most recent releases 17 primate species' genomes revealed that LTR7/HERVH have entered germlines of primates in Africa after the separation of the New World Monkey lineage, while LTR5_Hs/HERVK successfully colonized primates' germlines after the segregation of Gibbons' species. Subsequently, both LTR7 and LTR5_Hs undergo a marked ~ fourfold-fivefold expansion in genomes of Great Apes. Timelines of quantitative expansion of both LTR7 and LTR5_Hs loci during evolution of Great Apes appear to replicate the consensus evolutionary sequence of increasing cognitive and behavioral complexities of non-human primates, which seems particularly striking for LTR7 loci and 11 distinct LTR7 subfamilies. Consistent with previous reports, identified in this study, 351 human-specific (HS) insertions of LTR7 (175 loci) and LTR5_Hs (176 loci) regulatory sequences have been linked to genes implicated in establishment and maintenance of naïve and primed pluripotent states and preimplantation embryogenesis phenotypes. Unexpectedly, HS-LTRs manifest regulatory connectivity to genes encoding markers of 12 distinct cells' populations of fetal go**ds, as well as genes implicated in physiology and pathology of human spermatogenesis, including Y-linked spermatogenic failure, oligo- and azoospermia. Granular interrogations of genes linked with 11 distinct LTR7 subfamilies revealed that mammalian offspring survival (MOS) genes seem to remain one of consistent regulatory targets throughout ~ 30 MYA of the divergent evolution of LTR7 loci. Differential GSEA of MOS versus non-MOS genes identified clearly discernable dominant enrichment patterns of phenotypic traits affected by MOS genes linked with LTR7 (562 MOS genes) and LTR5_Hs (126 MOS genes) regulatory loci across the large panel of genomics and proteomics databases reflecting a broad spectrum of human physiological and pathological traits. GSEA of LTR7-linked MOS genes identified more than 2200 significantly enriched records of human common and rare diseases and gene signatures of 466 significantly enriched records of Human Phenotype Ontology traits, including Autosomal Dominant (92 genes) and Autosomal Recessive (93 genes) Inheritance. LTR7 regulatory elements appear linked with genes implicated in functional and morphological features of central nervous system, including synaptic transmission and protein-protein interactions at synapses, as well as gene signatures differentially regulated in cells of distinct neurodevelopmental stages and morphologically diverse cell types residing and functioning in human brain. These include Neural Stem/Precursor cells, Radial Glia cells, Bergman Glia cells, Pyramidal cells, Tanycytes, Immature neurons, Interneurons, Trigeminal neurons, GABAergic neurons, and Glutamatergic neurons. GSEA of LTR7-linked genes identified significantly enriched gene sets encoding markers of more than 80 specialized types of neurons and markers of 521 human brain regions, most prominently, subiculum and dentate gyrus. Identification and characterization of 1944 genes comprising high-confidence down-steam regulatory targets of LTR7 and/or LTR5_Hs loci validated and extended these observations by documenting marked enrichments for genes implicated in neoplasm metastasis, intellectual disability, autism, multiple cancer types, Alzheimer's, schizophrenia, and other brain disorders. Overall, genes representing down-stream regulatory targets of ancient retroviral LTRs exert the apparently cooperative and exceedingly broad phenotypic impacts on human physiology and pathology. This is exemplified by altered expression of 93% high-confidence LTR targets in cells infected by contemporary viruses, revealing a convergence of virus-inflicted aberrations on genomic regulatory circuitry governed by ancient retroviral LTR elements and interference with human cells' differentiation programs.

Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans -... Timelines of population-level effects of viruses on humans varied from the evolutionary scale of million years to contemporary spread of viral infections. Correspondingly, these events are exemplified by: (i) emergence of human endogenous retroviruses (HERVs) from ancient germline infections leading...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Remarkable progress in understanding genomics and epigenetics of stemness pathways highlights novel therapeutic targets for undruggable clinically lethal cancers and human brain disorders https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of neurodegenerative, neurodevelopmental, & neuropsychiatric disorders https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Sustained activity of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in a persisten failure of the homeostatic cycle of replenishment dying differentiated cells in human body. https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

In contrast to mutations-initiated/mutations-accumulating slowly progressing tumors, failures of epigenetic silencing of specific endogenous retroviral loci play a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Intrinsic propensity of stem cell like cancers to spread from the very early stages of tumor initiation and progression contributes to therapy resistance even if detected at the early stages. Cure of stem cell like cancers requires novel therapies.
https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Stem cell like cancer cells are epigenetically wired to survive in blood & lymph, travel throughout the body, spread and seed metastatic tumors at distant organs. Treatment would require epigenetic interference & chromatin silencing recovery tools.
https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Humans have 2 distinct types of cancers: 1.Curable if detected early mutations-accumulating slowly progressing tumors; 2.Therapy resistant clinically lethal stem cell like cancers due to loss of epigenetic silencing of specific retroviral loci. https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Genomics & epigenetics of naive & primed states of hESC reveals a global role of defined retroviral elements in human diseases & identifies diagnostic & therapeutic targets for stem cell like clinically lethal cancers https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/28/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Recent discoveries highlight limitations of a prevailing concept viewing all cancers as mutations-initiated/mutations-accumulating slowly progressing malignancies. https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 05/19/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Humans have 2 distinct types of cancers: 1.Curable if detected early mutations-accumulating slowly progressing tumors; 2.Therapy resistant clinically lethal stem cell like cancers due to loss of epigenetic silencing of specific retroviral loci. https://t.co/n7wcpXgIVh

Stem cell like cancer cells are epigenetically wired to survive in blood & lymph, travel throughout the body, spread and seed metastatic tumors at distant organs. Treatment would require epigenetic interference & chromatin silencing recovery tools.
https://t.co/n7wcpXgIVh

Intrinsic propensity of stem cell like cancers to spread from the very early stages of tumor initiation and progression contributes to therapy resistance even if detected at the early stages. Cure of stem cell like cancers requires novel therapies.
https://t.co/n7wcpXgIVh

In contrast to mutations-initiated/mutations-accumulating slowly progressing tumors, failures of epigenetic silencing of specific endogenous retroviral loci play a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in a persisten failure of the homeostatic cycle of replenishment dying differentiated cells in human body. https://t.co/n7wcpXgIVh

Sustained activity of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of therapy resistant clinically lethal cancers https://t.co/n7wcpXgIVh

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of neurodegenerative, neurodevelopmental, & neuropsychiatric disorders https://t.co/n7wcpXgIVh

Genomics & epigenetics of naive & primed states of hESC reveals a global role of defined retroviral elements in human diseases & identifies diagnostic & therapeutic targets for stem cell like clinically lethal cancers https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 04/25/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of neurodegenerative, neurodevelopmental, & neuropsychiatric disorders https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 04/25/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of neurodegenerative, neurodevelopmental, & neuropsychiatric disorders https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers 04/25/2021

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers

Activation of regulatory DNA sequences derived from certain Human Endogenous Retroviruses (HERV) plays a key role in development of therapy resistant undruggable clinically lethal cancers https://t.co/n7wcpXgIVh

Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic lo...

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... 12/24/2020

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets...

Regions in England with increased prevalence of N501Y mutations manifest distinct patterns of reported COVID-19 mortality.

The recent BMJ paper (1) reports identification of a novel SARS-CoV-2 strain carrying the N501Y mutation, which appears to spread rapidly within certain regions of the United Kingdom. Specifically, the N501Y mutants now comprises of 20%, 10%, and 3% of sequenced SARS-CoV-2 virus in Norfolk, Essex, and Suffolk, respectively (1). The clinical impacts, if any, of this rapidly spreading SARS-CoV-2 mutants remain unknown. It seems reasonable to speculate that the earliest potential impact on disease severity could be seeing by estimating the relative impact of the early COVID-19 deaths (defined as deaths recorded within 28 days after positive tests) as a proportion of the overall reported pandemic casualties with a COVID-19 certificate. The values for corresponding classification categories were obtained from the GOV.UK website:
Deaths | Coronavirus in the UK (data.gov.uk), analyzed, and results of these analyses are reported in the table below. It has been observed that regions with documented increased prevalence of the N501Y mutants manifest significantly higher proportions of the early (rapid) COVID-19 deaths compared to regions with relatively low prevalence of these mutants. Present findings suggest that the spread of the N501Y mutants may contribute to the excess of the early (rapid) COVID-19 mortality (Table 1).
Given the possibility that these mutants may acquire the ability to evade or escape the immunity induced by ongoing vaccination programs, the corresponding modifications to production of the mRNA vaccines should be urgently considered. It will be of interest to evaluate whether the suggested over-the-counter tripartite combination prophylaxis and therapy (2) and its individual medicinal components (Quercetin and Vitamin D; ref. 3) will be effective against the N501Y mutants.
Notably, when the N501Y pattern of the increased early (rapid) mortality was utilized to map the Upper tier LA England’s regions with similar patterns of increased early (rapid) COVID-19 mortality, it has been observed that more than one third (36%) of the Upper Tier LA regions manifest these patterns (at least 94% of all deaths with COVID-19 on the death certificate reported to occur within 28 days of positive test) (Figure 1). These observations suggest that the N501Y mutants may be spread more broadly in England that was estimated (1).

Table 1. Increased proportions of early (rapid) COVID-19 death in UK regions with increased prevalence of the N501Y SARS-CoV-2 mutants.
Classification category N501Y prevalence,% Death within 28 days of positive test Death with COVID-19 certificate Excess over 28 days death Percent of deaths after 28 days Percent of COVID-19 deaths within 28 days of positive test P value1 P value2
NORFOLK 20 576 569 0 0.0 101.2 1.53E-26 2.42E-27
ESSEX 10 1568 1680 112 6.7 93.3 2.78E-06 4.54E-07
SUFFOLK 3 646 663 17 2.6 97.4 1.78E-13 4.32E-14
England* UKN 55776 62149 6373 10.3 89.7 0.10966 NA
England 0.8 58566 65061 6495 10.0 90.0 NA 0.10966

Legend: England* designates values without Norfolk, Essex, Suffolk, which were reported to have high prevalence of the N501Y mutations (BMJ 2020;371:m4857 http://dx.doi.org/10.1136/bmj.m4857 Published: 16 December 2020); P values were estimated using 2-tail Fisher's exact test.

References
1. Covid-19: New coronavirus variant is identified in UK. [BMJ] 16th December. BMJ 2020;371:m4857 [accessed 23rd December 2020]; Available from https://www.bmj.com/content/371/bmj.m4857
2. Biomedicines 2020, 8(5), 129; https://doi.org/10.3390/biomedicines8050129
3. Twitter:

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically relevant cell types. Repressors and activators of the ACE2 a...

Genomic and Molecular Maps of Stemness and Malignant Regulatory Signatures 08/04/2020

Genomic and Molecular Maps of Stemness and Malignant Regulatory Signatures

SINGLE CELL GENOMICS VIEW TO MANAGEMENT OF CLINICALLY LETHAL CANCERS.

Genomic and Molecular Maps of Stemness and Malignant Regulatory Signatures Repetitive DNA sequences (repeats) colonized two-third of human genomes and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and pasted into chromosomes at multiple genomic l...

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... 06/09/2020

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets...

A must read COVID-19 paper.

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically relevant cell types. Repressors and activators of the ACE2 a...

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... 06/09/2020

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets...

A must read COVID-19 paper.

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically relevant cell types. Repressors and activators of the ACE2 a...

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... 06/09/2020

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets...

A must read COVID-19 paper.

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets... Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically relevant cell types. Repressors and activators of the ACE2 a...

mdpi.com 06/02/2020

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets...

Vitamin D/Quercetin/Estradiol alter expression of 244 of 332 (73%) SARS-CoV-2 targets in human cells, thus interfering with functions of ALL BUT ONE SARS-CoV-2 proteins. Report is here https://t.co/DAHm85mL8O Tripartite anti COVID therapy

mdpi.com Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically relevant cell types. Repressors and activators of the ACE2 a...

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Activation of endogeous retroviruses and development of cancer
You should learn about this if you or someone you know has cancer

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