09/23/2017
SCIENCE-ESTABLISHED BENEFITS OF CARNOSINE:
Repairs damaged cells
Fantastic anti-aging capabilities
Stabilizes blood sugar levels
Great anti-oxidant and anti-inflammatory
Good for your gut
Lots of cognitive benefits, especially for memory
Protects brain from toxins
Has anti-cancer properties
Anti-Depressant properties
Detoxifies the boody of toxins including heavy
metals.
SCIENCE-BACKED HEALTH BENEFITS OF
CARNOSINE - Part 1
1) Carnosine is Anti-Aging & Promotes Longevity. In rat studies, Carnosine levels have been shown to decline with age.
A number of experiments carried out in Australia showed that Carnosine reinvigorates cells as they approach the stage just before they die.
Cells were given Carnosine actually behaved and looked younger than untreated cells. Importantly, Carnosine reversed the signs of aging in these nearly dead cells. This means that Carnosine is a great hack for older people who want to look
younger, as well as those who want to continue looking young.
When signs of cellular aging soon reappeared Carnosine was taken away from the cells. Thus, it's probably necessary to take Carnosine long term to achieve continued benefits.
In a Russian study on mice, 44% of the mice given Carnosine had young, healthy looking fur into old age, compared to just 5% of the untreated mice. Likewise, 9% of the untreated mice behaved youthfully in old age, whereas 58% of the mice treated with Carnosine showed youthful vigor.
Protein glycation involves the reaction of protein and sugars in the blood stream. This reaction damages the proteins involved and is a major factor in aging. Carnosine has been shown to protect cellular proteins from damage in the following ways:
Carnosine bonds with the carbonyl/aldehyde groups that would otherwise bind with and damage proteins.
Carnosine controls and reduces the formation of oxidized sugars (AGEs) by performing as an antioxidant. Hence, from an anti-aging viewpoint, the fewer AGEs created in your body, the better
and younger you appear and in fact will perform.
Vegetarians lack Carnosine in their diet and thus have higher levels of AEGs than omnivores. Although, high fructose consumption could also play a role.
Carnosine promoted the production of vimentin when it was placed in the connective tissue of rats. Studies have suggested that vimenyin plays an essential role in the elimination of oxidized proteins that contribute to aging.
Carnosine prevents DNA, lipid, and protein damage by removing harmful metals via chelation. Carnosine prevents glycates easily and, in doing so, may spare important proteins, such as Hsc-70,
from glycation that, if prolonged, contributes to aging.
In one study, Carnosine increased blood cortisone levels, which have been linked to increased lifespan of human fibroblast cells.
In agreement with this, human fibroblast cells, supplemented with Carnosine had longer lifespans (413 days versus 139 days for the control group of cells).
Despite the speculative nature, some researchers have suggested that there is a relationship between the life-extending properties of anti-convulsants and their ability to increase Carnosine levels.
2) Carnosine Helps Fix Mitochrondria
Italian researchers found that mice given Carnosine had a complete reversal of age-related mitochondrial dysfunction. Indeed, the improvement was so dramatic that the treated mice actually had better mitochrondrial function than normal, healthy mice.
3) Carnosine May Heal the Gut.
In a cell study, Zinc Carnosine reduced damage to the hair-like structures, called villi, that line the body's gut.
Indomethacin triggers the death of a type of cell found in mouse guts. Zinc Carnosine prevented this.
When the stomach is exposed to bacteria, Zinc Carnosine decreases the production of inflammatory cytokines-- the sort of inflammation that leads to loating and discomfort.
4) Carnosine is Neuroprotective and Prevents
Neurodegeneration.
For example, MDA is a toxic end-product of lipid peroxidation. A study on rats demonstrated that Carnosine protects against MDA-induced toxicity and inhibits protein modification caused by MDA.
Taking common anesthetics typically results in enhanced SDM. Carnosine protects against the neurotoxic effects of SDM. Thus, it is suggested that Carnosine may be an important tool for limiting post-operative cognitive dysfunction.
Carnisine was also demonstrated to protect the mitochondria of cultured brain cells against nitric oxide-induced damage. In mice, Carnosine prevents the inflammation, cell damage and destruction, and free radical stress that occurs when the brain is starved of blood.
Again, in mice, Carnosine substantially improved neurological function after a stroke-like event.
Animal studies definitively show that Carnosine can affect brain function and activity.
Carnosine is manufactured by the brain and Carnosine-specific transporters are found in parts of the blood-brain barrier. Thus, it is no surprise that Carnosine can affect neurological function.
In mice, Carnosine is able to protect against cognitive dsyfunction caused by a high fat diet - thought to be possibly as a result of neutralizing toxic aldehydes which are developed by a high-fat diet.
Since Carnosine binds to zinc there is a likelihood that it plays some role in controlling the availability of zinc ions in neuronal tissue, especially in the olfactory lobe where both Carnosine and zinc are found in high levels. This is essential because the olfactory lobe controls smell--a loss of which is the first sign of neurodegeneration.
Carnosine increases mental capability in schizophrenics.
5) Carnosine Improves Memory
In one study after 3 months of Carnosine supplements, patients performed better on verbal memory tests.
In another study, elderly people also scored better on verbal memory tests when they were given a combination of Anserine and Carnosine.
Similarly, Carnosine when combined with polyphenols from blueberry and green tea and other amino acids it was verified that the health of existing neurons were maintained and promoted neurogenesis.
6) Carnosine is an Anti-Depressant
Studies have shown that Carnosine has anti-depressant activity in rats.
7) Carnosine Regulates the Immune System and
is Ani-Inflammatory.
Carnosine was shown to reduce excessive immune responses in patients who have overactive immune systems. Plus, Carnosine was found to increase the immune response in those with under-active immune systems (like the elderly).
This dual regulatory ability of Carnosine means it is an essential advantage for people with delicate immune systems such as those with allergies and compromised autoimmune conditions.
In the brain tissue, Carnosine reduces inflammation by lowering TNF-a as well as nitric oxide synthesis.
Carnosine has been found to reduce pro-inflammatory cytokines in gut cells that are exposed to H-pylori.
8) Carnosine May Treat Cancer
The anti-tumor propertes of Carnosine have been recognized more than 3 decades ago.
In this regard, Carnosine limits DNA damage that can change healthy cells into cancerous cells. Moreover, it inhibits tumor growth and assists prevent the spreading of existing cancers
(metatasis) to healthy tissue.
Further, Carnosine lower ATP levels in cancer cells, thereby depriving them of energy they need to develop.
Carnosine fed to Vitamin E-deficient rts increased the time period from exposure to a carcinogen to the development of a tumor.
Carnosine was found to be able to stop the spread of liver cancer cells by inhibiting the MMP-9 gene.
Carnosine increasees the efficacy of chemo-therapeutic drugs, like 5-FU.
Carnosine decreases AGEs, which are commonly blamed in causing cancer.
In neck cancer, Carnosine reduced the number of cancer cells by binding to caspase 3.
Carnosine, when combined with a protein shell (capsid) caused cell death in ung cancer by enhancing viral replication and affecting expression of Hsp27r.
Carnosine slows aging of cells that lead to ovarian cancer by reducing mitochondrial oxidative stress.
Cancer cells exposed directly to Carnosine were less able to thrive or proliferate and increased the frequency of death of such cancer cells.
