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RTHM, San Francisco, CA (2025)

07/16/2025

A new NIH RECOVER study followed hundreds of children under 6 and found that up to 15% met criteria for probable Long COVID—many with symptoms lasting over a year.
Distinct symptom patterns were seen by age group. Poor appetite, chronic cough, sleep issues, and fatigue were strongly linked to prior COVID-19 infection.

The authors estimate nearly 6 million U.S. children may be affected by Long COVID — surpassing Asthma as the most common chronic condition in kids today.

If you think your child may be showing signs of Long COVID, Jama Pediatrics created a resource to help you prepare: 🔗 https://jamanetwork.com/journals/jamapediatrics/fullarticle/2834486

Want research updates like this in your inbox? Sign up at rthm.com

🔗 DOI: 10.1001/jamapediatrics.2025.1066

07/11/2025

Some of the most prominent voices in AI have claimed it might cure all diseases within the next decade. In Can AI Crack Long COVID?, Tom Rosenblatt, CEO of Being and a chronic illness patient himself, reflects on whether that’s hype or possibility, and lands somewhere in between.

He explains how AI might solve the “latency problem” in medicine: the long gaps between symptoms, diagnosis, treatment, and follow-up. With AI delivering insights in seconds instead of months, he believes we could see a profound shift in how quickly and effectively diseases are treated. If integrated into everyday healthcare and embraced by clinicians, AI could help transform how we diagnose, manage, and ultimately prevent illness.

Want more insights? Watch Can AI Crack Long COVID? with Phillip Alvelda, PhD, Michael Snyder, PhD, Ian Simon, PhD, Tom Rosenblatt, MBA, and Jennifer Curtin, MD, streaming now on YouTube.

📽️: https://youtu.be/q5rh078FzvA

07/09/2025

Have you tried Ketotifen for Long COVID, ME/CFS, or MCAS-related symptoms?

According to real world data from patients using Ketotifen through RTHM Direct, 58.5% of RTHM Direct patients *who were prescribed ketotifen* reported noticeable improvements in their symptoms—and 80% of those who improved experienced moderate to significant benefits (as opposed to mild benefits).

Symptoms that improved the most in those reporting benefits were: post exertional malaise (PEM) - 53.8%, improved allergic symptoms 64.1%, improved food tolerance 59%, and better sleep 59%.

Ketotifen works as an oral antihistamine and mast cell stabilizer—helping to calm overactive immune responses that can contribute to food intolerance, poor sleep, and post-exertional malaise.

Swipe to see the top reported benefits—and why some patients are finding this to be a helpful tool in managing their complex chronic illness. You can explore whether compounded oral Ketotifen is right for you through a clinician-reviewed treatment assessment at RTHM Direct.

Click here to get started today: https://www.direct.rthm.com/

07/03/2025

Could AI help crack your Long COVID?

Ian Simon, former Director of the U.S. Department of Health and Human Services’ Office of Long COVID Research and Practice, shares how AI may be able to identify off-label drugs already on the market to treat Long COVID.

These insights could help identify treatment faster for patients and figure out how many existing drugs could benefit people living with the condition.

Watch the full panel discussion Can AI Crack Long COVID? featuring Phillip Alvelda, PhD, Michael Snyder, PhD, Ian Simon, PhD; Tom Rosenblatt, MBA, and Jennifer Curtin, MD—now available on our YouTube channel.

📽️: https://youtu.be/q5rh078FzvA

06/30/2025

A new study suggests that exercise doesn’t clear microclots in people with Long COVID—it just fragments them into smaller ones. These smaller clots are linked to increased inflammation and impaired oxygen transport, which may help explain post-exertional malaise (PEM) and post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even mild physical or mental effort.

Researchers observed these microclot and inflammatory changes even after submaximal exertion, highlighting the need for caution when recommending exercise-based therapies.

Want more research breakdowns like this? Sign up for our email list at https://linktr.ee/rthm_health

🔗 DOI: https://doi.org/10.21203/rs.3.rs-6717727/v1

06/23/2025

Have you tried Pyridostigmine for POTS yet?

In a clinical trial, 43% of 203 patients with Postural Orthostatic Tachycardia Syndrome (POTS) saw significant improvements in orthostatic intolerance after taking Pyridostigmine. This medication works by boosting acetylcholine, helping regulate autonomic nervous system function—which can be helpful in conditions like POTS, ME/CFS, and Long COVID.

Swipe to learn how it works — and why some clinicians are recommending it to stabilize heart rate, reduce PEM crashes, and support energy.

You can explore whether Pyridostigmine is right for you through a clinician-reviewed treatment assessment at RTHM Direct.

🔗: https://www.direct.rthm.com/treatments/pyridostigmine

PMID: 21410722

06/18/2025

Most people with Long COVID may not even know they have it!

In this clip, Phillip Alvelda, PhD, CEO of Brainworks Foundry, points out that many people today are living with new, unexplained symptoms—neurological, metabolic, reproductive, or immune-related—without ever being told the symptom onset could be linked to a COVID-19 infection. Phillip speaks to the enormous need for more awareness and cross specialty communication amongst clinicians to recognize the broad set of symptoms and conditions that can be triggered or worsened by a COVID infection.

Phillip explains how better tools and data integration are being developed for both clinicians and patients that can help uncover these connections, but that today, the awareness is still problematically low.

Watch the full webinar with Phillip Alvelda PhD, Michael Snyder PhD, Ian Simon PhD, Tom Rosenblatt MBA, and Jennifer Curtin MD, now available on our YouTube channel.

📽️: https://youtu.be/q5rh078FzvA

06/14/2025

The full replay of Can AI Crack Long COVID? is now live on YouTube.

This powerful conversation explores how AI is being used to identify biomarkers, repurpose medications, and help connect the dots for people living with Long COVID and other infection associated chronic conditions.

Hear from leaders in research, government, and patient advocacy on how AI is reshaping what's possible in diagnosis, treatment, and care.

📽️: https://youtu.be/q5rh078FzvA

(Clickable link in our linktree in bio)

06/09/2025

A new study from New Zealand found that over one-third of university students experienced measurable cognitive deficits—especially in executive function—up to 17 months after COVID-19 infection.

Even in a young, healthy population, the impacts on brain function were objectively detectable using neuropsych testing and brain oxygenation data.

Want insights like this sent straight to your inbox? Click on our linktree to join our email list for research breakdowns, treatment updates, and tools for navigating Long COVID and ME/CFS.

🔗 DOI: 10.1016/j.bbi.2024.12.002

06/08/2025

Join us live on June 12 at 1pm PST for a 75-minute webinar exploring how AI is reshaping the future of diagnosis and treatment for Long COVID and infection associated chronic conditions (IACCs).

Our expert panel will explore:

→ How you can use AI to advance your own care.
→ A foundational overview of AI in healthcare: what it can and can’t do.
→ How AI is accelerating drug discovery and treatment personalization.

Whether you're a patient, researcher, or clinician, this conversation is for you.

Sign up here: https://us06web.zoom.us/webinar/register/WN_bREZZCH5Qw2aVSrd4GTi6A #/registration

06/05/2025

In our last webinar, Dr. David Putrino, Dr. Leo Galland, and Dr. Stuart Malcolm explored what it means to treat infection associated chronic conditions when the science is still evolving—sharing what they’re trying, what’s showing early promise, and what’s worth watching.

Next, we’re looking ahead: Can AI Crack Long COVID?

With tools like RTHM Intelligence already turning patient data into actionable insights, this next session will bring together leaders in medicine, research, and technology to examine how AI could transform diagnosis, treatment, and care delivery.

Sign up for our next webinar June 12 at 1pm PST/ 4pm EST. 🔗:https://us06web.zoom.us/webinar/register/WN_bREZZCH5Qw2aVSrd4GTi6A #/registration

Can’t make it? We will post the webinar replay on our YouTube channel after.

06/02/2025

Can AI change the future of Long COVID care?

Our upcoming webinar brings together experts in genomics, artificial intelligence, and translational medicine to explore how AI is reshaping diagnosis and treatment for Long COVID and related chronic conditions.

From identifying biomarkers to predicting treatment response, AI is moving medicine towards faster, more personalized care. We'll also talk about what's already possible—and what's just around the corner.

Join us June 12th at 1pm PST/ 4pm EST. 🔗:https://us06web.zoom.us/webinar/register/WN_bREZZCH5Qw2aVSrd4GTi6A #/registration

Can’t make it? We will post the webinar replay on our YouTube channel.

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