01/12/2026
VNS therapy exists because a scientist went to Lamaze class with his pregnant wife...
In the 1980s, neuroscientist Jake Zabara was studying the vagus nerve in dogs when he started attending childbirth preparation classes.
Sitting there learning breathing techniques, he asked a question most people wouldn't think to ask: How does controlled breathing actually reduce the pain of contractions?
His hypothesis: the vagus nerve, running from the diaphragm to the brain, was the pathway.
He went back to his lab, isolated the vagus nerve in dogs, and started stimulating it directly. The rest became the foundation for a treatment that now helps patients with severe, treatment-resistant depression.
Another example of serendipity in psychiatry. The biggest breakthroughs often come from paying attention to the small, strange observations.
Learn more about Vagus Nerve Stimulation and keep your finger on the pulse of the future of psychiatry. Listen to the full episode on Psychiatry Tomorrow.
This episode features William Sauvé, MD, Lucian Manu, M.D., Carlene MacMillan, MD, FCTMSS,DFAACAP
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