Ossium Health

04/08/2026

04/08/2026

Ossium Health, a bone marrow bank co-founded by Kevin Caldwell and Erik Woods, is aiming to make bone marrow transplants more accessible. Caldwell says Indiana is well-positioned to become the epicenter of the biosciences revolution due to its long history of advanced research and pharmaceutical manufacturing. https://tinyurl.com/24wtncyj

04/08/2026

Today, we had the honor of welcoming Governor Mike Braun to our manufacturing facility.

During his visit, Governor Braun heard directly from patients who received transplants with Ossium bone marrow, the physicians who performed them, and the team responsible for manufacturing this life-saving therapy.

Hearing these stories firsthand from patients whose lives have been transformed and clinicians pushing the boundaries of care brings our mission into sharp focus. This is why we do what we do.

Thank you to Governor Braun and everyone who joined us for taking the time to see our work up close and engage in the future of bone marrow transplantation.

Watch a video recap of the event here:

Gov. Mike Braun on Tuesday toured the world's first bone marrow bank on Indianapolis northwest side.

03/27/2026

What if bone marrow could be stored, shipped, and used on demand — just like a drug?

That's the question at the heart of an interview featuring our Co-Founder & CEO Kevin Caldwell on Progress, Potential, And Possibilities with Ira Pastor. In the conversation, Kevin walks through the company's progress over the past year:

🔹PRESERVE I trial interim update: 100% neutrophil engraftment, 100% platelet recovery, and zero relapses at one year.
🔹Enabled six emergency transplants completed with less than 72 hours notice
🔹Manufacturing methods now published in peer-reviewed Cytotherapy article
🔹PRESERVE II: launching later this year — a large, multi-arm study comparing Ossium transplant outcomes head-to-head against living donor transplants, both related and unrelated
🔹Entering the WMDA database by this summer — opening access to transplant centers worldwide

▶️ Watch the full interview:

Bone marrow transplants have always depended on finding the right donor at the right time. But what if bone marrow could be stored, shipped, and used on dema...

03/03/2026

We’re honored to share that Ossium Health has once again been selected for Forbes' annual America’s Best Startup Employers list. This recognition reflects the strength of our team and our culture that’s grounded in impact, truth, ownership, and grit. Our employees are united by the opportunity to develop transformative bioengineering solutions that improve human health and expand what’s possible in medicine. We’re deeply grateful to our team for their passion and dedication, which continue to drive our mission forward.

See the full list here:

The Forbes Best Startup Employers of 2026 list features the top innovative startup employers in America offering exciting opportunities. See who made the list.

02/23/2026

For more than two decades, the U.S. Government has made purposeful investments to develop medical countermeasures that can diagnose, mitigate, and treat injuries in the event of a radiological or nuclear emergency. These programs rely on strong public-private partnerships, and we’re proud to be part of this effort to ensure the nation is prepared should the unthinkable occur.

Recognizing that bone marrow is among the most sensitive and essential systems affected by radiation exposure, the Government made key investments in therapies that address myeloablation of the bone marrow following exposure to high doses of irradiation.

These critical medical countermeasures, including Ossium’s bone marrow bank, are described in a recently published review article:

“Innovative sourcing and cryopreservation of bone marrow from deceased organ donors (alternative hematopoietic progenitor cells (HPC) grafts) by Ossium Health has been explored as a means of obtaining large quantities of banked HPCs for use in myeloablated patients. These cell populations have been well-characterized, and their functionality has been found to be equivalent to live bone marrow donations.” (DiCarlo et al., 2025)

Read the full article: https://pmc.ncbi.nlm.nih.gov/articles/PMC12313093/

02/21/2026

Advances in cellular therapy are creating new possibilities for patients with blood cancers and expanding access to bone marrow transplantation beyond traditional donor sources. Franciscan Health is at the forefront of this progress, offering innovative transplant approaches, including the use of bone marrow recovered from deceased organ donors. This on-demand graft source helps reduce delays, expand donor availability, and ensure more patients have timely access to potentially lifesaving transplants.

Learn more ⬇️

10/15/2025

A recent editorial in the American Society of Clinical Oncology Journal of Clinical Oncology highlights an urgent truth for blood cancer patients: how quickly a bone marrow transplant can be performed is as critical as HLA matching.

Referencing results from the BMT CTN 1702 study, author Alessandro Rambaldi, MD emphasizes that for high-risk blood cancers like acute leukemia, faster access to a donor can make the difference between cure and relapse:

“When the risk of relapse is high, as in the case of acute leukemia patients, the shorter the time to transplant, the better the outcome. This seems particularly important, for urgent cases for whom a timeline of 6 weeks or less from unrelated search initiation to graft infusion should be considered ideal. Accordingly, disease biology, patient-related variables, and keeping the time to transplant as short as possible are more important than waiting for a better HLA-matched donor.”

At Ossium Health, we’re making that rapid access a reality. Our cryopreserved bone marrow banking platform ensures donors are available on demand, enabling bone marrow transplants to be performed within 72 hours of the initial donor search.

Read the full editorial in JCO:
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Partial AccessEDITORIALSSeptember 30, 2025 Share on Looking for the Best Allogeneic Donor and the BMT CTN 1702 Study: Noli Tempus PerdereAuthor: Alessandro Rambaldi, MD https://orcid.org/0000-0002-3739-7502 [email protected]Authors Info & AffiliationsPublication: Journal of Clinical OncologyNewest ...

08/22/2025

We’re excited to share that our CEO, Co-Founder & President, Kevin Caldwell, was featured on the Biotech2050 Podcast with Rahul Chaturvedi.

In this episode, Kevin reflects on:
🔹 Building the first scalable bone marrow bank from organ donors
🔹 Ossium’s fully integrated approach to cell therapy
🔹 Lessons from raising $130M+ and navigating regulatory pathways
🔹 The conviction required to extend human healthspan through regenerative medicine

🎧 Listen here:

Podcast Episode · Biotech 2050 Podcast · 08/21/2025 · 36m

04/25/2025

Tomorrow at the Vitalist Bay Summit, Ossium CEO Kevin Caldwell is speaking on how Ossium's work in treating acute malignancies is paving the way to an expansion into preventative longevity medicine. Catch the talk at 2:10pm on the main stage.

04/14/2025

Happy National Donate Life Blue & Green Day!

02/19/2025

Our CEO Kevin Caldwell recently joined Ira Pastor on the Progress, Potential, And Possibilities podcast to discuss how Ossium is advancing stem cell science to improve patient outcomes and build a healthier future.

Listen to the conversation here:

Kevin Caldwell is CEO, Co-Founder & President of Ossium Health ( https://ossiumhealth.com/ ), a commercial stage bioengineering company that leverages its pr...