Ossium Health

05/28/2026

When longevity medicine arrives at scale, it will depend as much on logistics as on biology. That's the throughline of a new Longevity.Technology feature on Ossium and a conversation with our Co-Founder & CEO Kevin Caldwell.

Bone marrow transplantation has been quietly extraordinary for decades: a procedure that rebuilds a patient's entire blood and immune system from donor-derived stem cells. But it has remained dependent on living donors, narrow collection windows, and choreography that often breaks when disease moves faster than the donor coordination.

Ossium is building the alternative: a cryopreserved bank of organ donor-derived bone marrow, processed and characterized for on-demand use.

The near-term goal is access. The longer-term implication, as the piece explores, is harder to ignore: if hematopoietic stem cells sit at the root of immune decline, the infrastructure for transplantation may also be infrastructure for immune renewal.

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As immunosenescence drives systemic disease, banked bone marrow could scale from a transplant tool into healthspan infrastructure.

05/26/2026

Ossium Health CEO Kevin Caldwell recently joined Chris Leidli on for a conversation about how we're reshaping the future of bone marrow transplantation and immune health.

The episode covers:
🔹 Why bone marrow transplants – one of the most powerful procedures in medicine — have been historically underutilized
🔹 How Ossium’s supply of banked bone marrow has reduced transplant lead times from months to as little as 48 hours
🔹 The potential for our bone marrow bank to serve as a foundation for a new generation of allogeneic, off-the-shelf cell therapies
🔹 How bone marrow transplants could eventually be used proactively to reset an aging immune system before catastrophic disease strikes

🎧 Listen here:

Podcast Episode · Rx for Biotech · April 28 · 29m

05/08/2026

Congratulations to the team at UAB O'Neal Cancer Center for performing Alabama’s first transplant with organ donor bone marrow sourced from Ossium’s bank. This is a major step forward for patients across the state who need a transplant urgently, as access to on-demand organ donor marrow can mean the difference between receiving life-saving treatment and missing the window entirely.

In the words of UAB’s Dr. Omer Jamy: "This advancement reflects our commitment to ensuring more patients have access to curative therapies when they need them most."

🔗 Read more:

UAB physician performs Alabama’s first deceased donor bone marrow transplant

04/28/2026

04/28/2026

The Indianapolis Business Journal spent time with our team this month and the result is a great read covering everything from how we source and bank marrow to what it means for patients who have run out of other options.

Dr. Jodi Skiles at Riley Hospital for Children sums it up well: "Having an option like Ossium really has the potential to be a major game-changer for our patient population."

🔗https://www.ibj.com/articles/ossium-health-aims-to-revolutionize-role-of-bone-marrow-banks

04/08/2026

04/08/2026

Ossium Health, a bone marrow bank co-founded by Kevin Caldwell and Erik Woods, is aiming to make bone marrow transplants more accessible. Caldwell says Indiana is well-positioned to become the epicenter of the biosciences revolution due to its long history of advanced research and pharmaceutical manufacturing. https://tinyurl.com/24wtncyj

04/08/2026

Today, we had the honor of welcoming Governor Mike Braun to our manufacturing facility.

During his visit, Governor Braun heard directly from patients who received transplants with Ossium bone marrow, the physicians who performed them, and the team responsible for manufacturing this life-saving therapy.

Hearing these stories firsthand from patients whose lives have been transformed and clinicians pushing the boundaries of care brings our mission into sharp focus. This is why we do what we do.

Thank you to Governor Braun and everyone who joined us for taking the time to see our work up close and engage in the future of bone marrow transplantation.

Watch a video recap of the event here:

Gov. Mike Braun on Tuesday toured the world's first bone marrow bank on Indianapolis northwest side.

03/27/2026

What if bone marrow could be stored, shipped, and used on demand — just like a drug?

That's the question at the heart of an interview featuring our Co-Founder & CEO Kevin Caldwell on Progress, Potential, And Possibilities with Ira Pastor. In the conversation, Kevin walks through the company's progress over the past year:

🔹PRESERVE I trial interim update: 100% neutrophil engraftment, 100% platelet recovery, and zero relapses at one year.
🔹Enabled six emergency transplants completed with less than 72 hours notice
🔹Manufacturing methods now published in peer-reviewed Cytotherapy article
🔹PRESERVE II: launching later this year — a large, multi-arm study comparing Ossium transplant outcomes head-to-head against living donor transplants, both related and unrelated
🔹Entering the WMDA database by this summer — opening access to transplant centers worldwide

▶️ Watch the full interview:

Bone marrow transplants have always depended on finding the right donor at the right time. But what if bone marrow could be stored, shipped, and used on dema...

03/03/2026

We’re honored to share that Ossium Health has once again been selected for Forbes' annual America’s Best Startup Employers list. This recognition reflects the strength of our team and our culture that’s grounded in impact, truth, ownership, and grit. Our employees are united by the opportunity to develop transformative bioengineering solutions that improve human health and expand what’s possible in medicine. We’re deeply grateful to our team for their passion and dedication, which continue to drive our mission forward.

See the full list here:

The Forbes Best Startup Employers of 2026 list features the top innovative startup employers in America offering exciting opportunities. See who made the list.