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NCIRE - Northern California Institute for Research and Education, Inc.

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NCIRE - Northern California Institute for Research and Education, Inc.

NCIRE – Northern California Institute for Research and Education, Inc. has one mission and one goal: Veterans' Health.

We are the leading nonprofit research institute in the United States devoted to advancing Veterans' health research. Through new technologies, novel scientific insights, and international clinical collaborations, we strive to set a new standard of health care for veterans and military personnel.

04/10/2026

Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia

White matter (WM) is a key substrate for interregional neural communication and cognitive function, yet the role of WM glucose metabolism in cognitive aging has been understudied.

Drs. Michael Weiner, Duygu Tosun-Turgut, and Rachel Nosheny with the NCIRE-supported NIH Alzheimer's Disease Neuroimaging Initiative contributed to the study titled "Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia”.

Read it here: https://www.nature.com/articles/s41467-026-70707-6

04/06/2026

This National Public Health Week (NPHW), April 6th– 12th. An initiative of the American Public Health Association, NPHW is a time to recognize all facets of Public Health and the holistic approach it takes for our communities to thrive. It is a goal that takes the combined efforts of individuals, families, communities, and the Public Health field to achieve.

NCIRE thanks our Public Health Workers and our Research Community for their tireless efforts to ensure improved public health.

Learn More: https://nphw.org/themes-and-facts

04/03/2026

April is Parkinson’s Disease Awareness Month.

Parkinson's disease (PD) is a progressive movement disorder of the nervous system. It causes nerve cells (neurons) in parts of the brain to weaken, become damaged, and die, leading to symptoms that include problems with movement, tremors, stiffness, and impaired balance. As symptoms progress, people with Parkinson’s disease (PD) may have difficulty walking, talking, or completing other simple tasks.

In the U.S., nearly 1 million people are living with Parkinson’s disease, with about 90,000 being diagnosed each year.

Following Alzheimer’s disease, Parkinson's disease (PD) is the second-most common neurodegenerative disorder in the United States. Most people diagnosed with PD are age 60 years or older, however, an estimated 5 to 10 percent of people with PD are diagnosed before the age of 50.

This Parkinson’s Disease Awareness Month, NCIRE thanks our supported Principal Investigators, Drs. Raymond Swanson and Duygu Tosun-Turgut, for their work in PD-related research.

Learn more:
https://www.ninds.nih.gov/health-information/disorders/parkinsons-disease
https://www.parkinsons.va.gov/patients.asp

04/02/2026

Dr. Scott R. Bauer is featured in the latest Q&A article published in the Volume 30, Spring 2026 Issue of Details News Awards (DNA) Newsletter, an NCIRE production:
https://www.linkedin.com/pulse/qa-dr-scott-r-bauer-ncire-7qwkf

You may read the newsletter in full on our website, www.ncire.org, under the “Resources” tab.

Scott R. Bauer, MD, MS is an Associate Professor of Medicine, Urology, Epidemiology & Biostatistics at the University of California, San Francisco and a Staff Physician with the Division of General Internal Medicine at the San Francisco VA Health Care System.

03/30/2026

Dr. Franklin W. Huang is featured in the latest Focus on Research article published in the Volume 30, Spring 2026 Issue of Details News Awards (DNA) Newsletter, an NCIRE production: https://www.linkedin.com/pulse/focus-research-lab-drives-quest-eliminate-prostate-cancer-disparities-nhnrc

You may read the newsletter in full on our website, www.ncire.org, under the “Resources” tab.

Franklin W. Huang, MD, PhD is an Associate Professor in Residence for the Department of Medicine at the University of California, San Francisco (UCSF), and is the Principal Investigator for the San Francisco VA Health Care System/UCSF Precision Oncology Center of Excellence.

03/29/2026

March 29th marks the date that the last combat troops left South Vietnam, the beginning of the end of America’s involvement in the Vietnam War.

On National Vietnam War Veterans Day, NCIRE honors Vietnam Veterans and their families for their service and remembers the men and women who put the lives of others ahead of their own to serve during one of America’s longest foreign wars.

03/25/2026

On Medal of Honor Day, NCIRE honors those who have received the highest award for military valor in Action for distinguishing themselves “conspicuously by gallantry and intrepidity at the risk of their life above and beyond the call duty.”

As of early 2026, 3,547 service members received the Medal of Honor, since the first Medal of Honor presentation on March 25, 1863, to the Andrew Raiders, a cadre who showed the values of courage, commitment, sacrifice, integrity, and patriotism which are still important to Recipients of the Medal of Honor today.

On this Medal of Honor Day, NCIRE pays tribute to the brave service members recognized for their selfless acts to protect and serve their country. We salute your service and sacrifice.

Learn more: https://www.cmohs.org/

03/17/2026

A Cluster Randomized Trial of a Vaccination Communication Educational Intervention: Impact on COVID-19 Vaccine Uptake in Veterans

Despite its safety and effectiveness, COVID-19 vaccine uptake declined later in the pandemic.

In a study co-authored by Board Member Dr. Karen Seal, and Drs. Jennifer K. Manuel; Natalie Purcell and Brian Borsari, researchers evaluated the effectiveness of a Motivational Interviewing (MI)-informed educational intervention for healthcare providers and staff on vaccination communication. They hypothesized that educating providers and staff about non-judgmental, collaborative discussions would enhance vaccine uptake in Veterans.

Read more: https://link.springer.com/article/10.1007/s11606-026-10209-9

03/12/2026

Chronic kidney disease (CKD) is a major and growing global health challenge, affecting 1 in 10 people worldwide.

Often silent in its early stages, CKD can progress unnoticed until it causes severe health consequences, profoundly impacting individuals, families, and communities. The disease significantly increases the risk of cardiovascular complications, reduces quality of life, and may advance to kidney failure. Its burden is unevenly distributed, disproportionately affecting disadvantaged populations and exacerbating existing health inequities.

Screening for CKD in individuals with diabetes, high blood sugar or heart disease using a simple blood test for eGFR and urine sample for urine albumin is critical in early disease detection and initiation of life-saving therapies.

The international kidney guideline organization Kidney Disease Improving Global Outcomes (KDIGO) released the 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease, authored by NCIRE Board Chair, and co-founder/co-director of the Kidney Health Research Collaborative (KHRC), Dr. Michael Shlipak. To read this and other kidney health-related guidelines, visit https://kdigo.org/

Additional resources for patients and their providers are available through www.kidney.org

The National Kidney Foundation, soon to be led by pre-elect Dr. Michelle Estrella in October 2026, is working closely with the Veterans Health Administration National Kidney Program to improve kidney care delivery for Veterans.

NCIRE thanks the Research Community for their efforts to treat and prevent worldwide.

Learn more:
https://khrc.ucsf.edu

https://www.worldkidneyday.org/2026-campaign/

03/11/2026

Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults

Heart failure and its main subtypes, heart failure with preserved ejection fraction and heart failure with reduced ejection fraction, impose an enormous health burden on elders. Assessment of the circulating proteins to illuminate the development of heart failure could open new opportunities for treatment.

The researchers identified and replicated 55 novel protein markers of heart failure or its subtypes, and 7 new, possibly causal proteins. These proteins may enhance risk prediction, improve understanding of pathobiology, and help prioritize targets for therapeutic development of these foremost disorders in elders.

Dr. Jorge Kizer co-published the study titled “Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults”.

Read more: https://www.ahajournals.org/doi/10.1161/CIRCGEN.124.005031

03/08/2026

March 8th is International Women's Day (IWD), a global celebration of women's rights and gender equality that aims to highlight the continued struggles women confront across the globe and strives for a world free of bias, stereotypes, and discrimination.

This year’s IWD theme “Give To Gain” emphasizes the power of reciprocity and support. When people, organizations, and communities give generously, opportunities and support for women increase. Giving is not a subtraction, it's intentional multiplication. When women thrive, we all rise.

NCIRE celebrates International Women’s Day and works to expand opportunities for women in biomedical research. To help support our endeavor, visit https://www.ncire.org/donation

https://www.internationalwomensday.com/

03/06/2026

Biology of novel LpxC inhibitors for Neisseria gonorrhoeae informs strategy for therapeutic innovation

Neisseria gonorrhoeae is a major global pathogen and the second most commonly reported cause of sexually transmitted infection in the United States. In 2023, a total of 601,319 gonorrhea cases were reported to the Centers for Disease Control and Prevention (CDC). Notably, adults aged 55 and older experienced a 16.8% increase in cases between 2020 and 2023.

The CDC has designated gonorrhea as an urgent public health threat due to the absence of a vaccine and the bacterium’s growing resistance to all but one remaining class of antibiotics.

In response to this challenge, Drs. Constance John and Gary Jarvis co published a study detailing the development and testing of novel inhibitors targeting an enzyme that may carry a lower risk of driving treatment resistance. The researchers also identified a potential dual therapy strategy incorporating these new inhibitors, offering promising avenues for future clinical application.
Read more: https://pubmed.ncbi.nlm.nih.gov/41524410/

Address

4150 Clement Street (151NC)
San Francisco, CA
94121

Opening Hours

Monday	8am - 4:30pm
Tuesday	8am - 4:30pm
Wednesday	8am - 4:30pm
Thursday	8am - 4:30pm
Friday	8am - 4:30pm

Telephone

+14157506954

Website

https://bsky.app/profile/ncire.org, https://www.linkedin.com/company/ncire/, https://www.ncire.org/

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Through new technologies, novel scientific insights, and international clinical collaborations, we strive to set a new standard of health care for veterans and military personnel.