UCSF Department of Neurological Surgery

The Neurosurgery Department at UCSF is home to leading physicians and scientists dedicated to treating patients with neurosurgical disorders and to the search for better therapies and cures.

Our mission is to provide the best clinical care to our patients, investigate the most promising advances in neuroscience research, and train tomorrow's leaders in neurosurgery.

Operating as usual

Timeline Photos 07/12/2021

Using a new technology developed at UCSF, researchers have generated the first maps of how our chromosomes are organized in the developing brain. It is increasingly understood that location of chromosomes within the nucleus regulates gene function, with consequences for both development and disease.

Published in Nature Neuroscience, Daniel Lim, MD, PhD and colleagues describe their latest findings: “Almost everything that we’ve previously known about genome organization was derived from cell culture studies," said Lim. “This is the only study, to date, focused on in vivo tissues.”

“We are really starting to explore how the genome is organized relative to these structures during development or during disease,” said co-first author and postdoctoral scholar Sajad Ahanger, PhD. “I think this opens up a lot of exciting opportunities not only in the brain, but different organs and systems.”

Read the full interview ➡ https://neurosurgery.ucsf.edu/news/new-technology-reveals-genome-architecture-within-nucleus
Read the research publication ➡ https://www.nature.com/articles/s41593-021-00879-5

Using a new technology developed at UCSF, researchers have generated the first maps of how our chromosomes are organized in the developing brain. It is increasingly understood that location of chromosomes within the nucleus regulates gene function, with consequences for both development and disease.

Published in Nature Neuroscience, Daniel Lim, MD, PhD and colleagues describe their latest findings: “Almost everything that we’ve previously known about genome organization was derived from cell culture studies," said Lim. “This is the only study, to date, focused on in vivo tissues.”

“We are really starting to explore how the genome is organized relative to these structures during development or during disease,” said co-first author and postdoctoral scholar Sajad Ahanger, PhD. “I think this opens up a lot of exciting opportunities not only in the brain, but different organs and systems.”

Read the full interview ➡ https://neurosurgery.ucsf.edu/news/new-technology-reveals-genome-architecture-within-nucleus
Read the research publication ➡ https://www.nature.com/articles/s41593-021-00879-5

Timeline Photos 07/09/2021

Featured on the cover of Neurosurgery, UCSF Health neurosurgeons Dr. Mitchel Berger, Dr. Hervey-Jumper and team provide a comprehensive review of cognitive impairment in adult glioma. In this Editor's Choice article, they discuss factors associated with neurocognitive impairment, cognitive testing for patient assessment, and broader context for how tumors disrupt and interact with normal brain networks.

Read the publication here ➡ https://academic.oup.com/neurosurgery/article/89/1/1/6027131

Featured on the cover of Neurosurgery, UCSF Health neurosurgeons Dr. Mitchel Berger, Dr. Hervey-Jumper and team provide a comprehensive review of cognitive impairment in adult glioma. In this Editor's Choice article, they discuss factors associated with neurocognitive impairment, cognitive testing for patient assessment, and broader context for how tumors disrupt and interact with normal brain networks.

Read the publication here ➡ https://academic.oup.com/neurosurgery/article/89/1/1/6027131

07/07/2021

"Usually when you come up with something new, the first thing you are reflexively told is that it’s not a good idea. For me that’s usually a sign to continue exploring it."

Please welcome our new faculty member, Ezequiel 'Eze' Goldschmidt, MD, PhD! Having trained at University of Pittsburgh Neurosurgery where many of the techniques were developed, Dr. Goldschmidt brings expertise in complex and minimally invasive skull base surgery. He joins us from Karolinska Institutet, where he recently completed the prestigious William P. Van Wagenen Fellowship for his pioneering research on novel mechanisms of neuroplasticity.

Read the full interview with Dr. Goldschmidt: https://neurosurgery.ucsf.edu/news/skull-base-surgeon-joins-ucsf-brain-tumor-center-team

"Usually when you come up with something new, the first thing you are reflexively told is that it’s not a good idea. For me that’s usually a sign to continue exploring it."

Please welcome our new faculty member, Ezequiel 'Eze' Goldschmidt, MD, PhD! Having trained at University of Pittsburgh Neurosurgery where many of the techniques were developed, Dr. Goldschmidt brings expertise in complex and minimally invasive skull base surgery. He joins us from Karolinska Institutet, where he recently completed the prestigious William P. Van Wagenen Fellowship for his pioneering research on novel mechanisms of neuroplasticity.

Read the full interview with Dr. Goldschmidt: https://neurosurgery.ucsf.edu/news/skull-base-surgeon-joins-ucsf-brain-tumor-center-team

Timeline Photos 07/06/2021

How do systemic cancers like lung cancer cause cognitive impairments? Featured in JAMA Oncology, UCSF neurosurgeon Dr. Shawn Hervey-Jumper and Stanford neuro-oncologist Dr. Michelle Monje discuss the latest findings from Dr. Carsten Finke's group in Berlin.

Read the original investigation on neuronal autoantibodies by Bartels et al ➡️ https://jamanetwork.com/journals/jamaoncology/article-abstract/2781389
Read the invited commentary ➡️ https://jamanetwork.com/journals/jamaoncology/article-abstract/2781393

How do systemic cancers like lung cancer cause cognitive impairments? Featured in JAMA Oncology, UCSF neurosurgeon Dr. Shawn Hervey-Jumper and Stanford neuro-oncologist Dr. Michelle Monje discuss the latest findings from Dr. Carsten Finke's group in Berlin.

Read the original investigation on neuronal autoantibodies by Bartels et al ➡️ https://jamanetwork.com/journals/jamaoncology/article-abstract/2781389
Read the invited commentary ➡️ https://jamanetwork.com/journals/jamaoncology/article-abstract/2781393

Timeline Photos 07/06/2021

Join us for a special webinar on July 21, "Neuroplasticity and the Human Brain: What We Know."

We know that brain tumors and their treatment can have a significant impact on cognition. What do we know about the brain’s ability to recover and create new neural pathways? Join UCSF Health neurosurgeon and researcher Shawn Hervey-Jumper, MD, as we discuss what we know about genetic and molecular contributions to functional recovery, as well as therapies and strategies to promote brain health.

There is no cost to attend, but pre-registration is required. This event is open to all patients and families: https://calendar.ucsf.edu/event/webinar_neuroplasticity_and_the_human_brainwhat_we_know

Join us for a special webinar on July 21, "Neuroplasticity and the Human Brain: What We Know."

We know that brain tumors and their treatment can have a significant impact on cognition. What do we know about the brain’s ability to recover and create new neural pathways? Join UCSF Health neurosurgeon and researcher Shawn Hervey-Jumper, MD, as we discuss what we know about genetic and molecular contributions to functional recovery, as well as therapies and strategies to promote brain health.

There is no cost to attend, but pre-registration is required. This event is open to all patients and families: https://calendar.ucsf.edu/event/webinar_neuroplasticity_and_the_human_brainwhat_we_know

Timeline Photos 07/01/2021

We are excited to welcome these brilliant folks to the team! Please welcome our new fellows:
✔ Dr. Nitin Agarwal
✔ Dr. Ernest Barthélemy
✔ Dr. Iahn Cajigas Gonzalez
✔ Dr. Saman Shabani
✔ Dr. Daniel Tonetti
✔ Dr. Michelle Wedemeyer
✔ Dr. Jos'lyn Woodard

We are excited to welcome these brilliant folks to the team! Please welcome our new fellows:
✔ Dr. Nitin Agarwal
✔ Dr. Ernest Barthélemy
✔ Dr. Iahn Cajigas Gonzalez
✔ Dr. Saman Shabani
✔ Dr. Daniel Tonetti
✔ Dr. Michelle Wedemeyer
✔ Dr. Jos'lyn Woodard

06/30/2021

BarabanS_iScience_20210630.mp4

Published in iScience, the Baraban Lab characterizes disordered brain activity occurring in the periods between seizures, in a zebrafish model of epilepsy. Using in vivo calcium imaging, shown here, they find spontaneous, synchronized activity in local clusters of neurons, representing a potential functional biomarker for epilepsy.

Read the research publication here: https://www.cell.com/iscience/fulltext/S2589-0042(21)00526-5

Credit: Liu J, Salvati KA, Baraban SC. In vivo calcium imaging reveals disordered interictal network dynamics in epileptic stxbp1b zebrafish. iScience. 2021 May 19;24(6):102558. [CC BY 4.0]

Timeline Photos 06/29/2021

It's not too late to register! Join us for Neurosurgery Update 2021. This CME will cover the latest advances in the field of neurosurgery.

Register here: https://www.ucsfcme.com/2022/MNS22001/info.html

It's not too late to register! Join us for Neurosurgery Update 2021. This CME will cover the latest advances in the field of neurosurgery.

Register here: https://www.ucsfcme.com/2022/MNS22001/info.html

Photos from UCSF Department of Neurological Surgery's post 06/25/2021

Congratulations to graduating chief resident Ethan Winkler, MD, PhD, who will be starting an Endovascular Surgical Neuroradiology Fellowship and Cerebrovascular and Skull Base Fellowship at Barrow Neurological Institute! 🎉🎓

Pictured here, Dr. Winkler in the lab, and resecting an acoustic neuroma with mentor UCSF Health neurosurgeon Philip Theodosopoulos, MD.

"I want to thank you for your incredible efforts and dedication not just to my patients, but also to the work that we're doing and also to the care of the patients of all of our faculty," said another mentor, neurosurgeon Adib Abla, MD.

Dr. Winkler's research highlights include
☑️ Defining cellular and molecular mechanisms responsible for arteriovenous malformations in the Lim and Nowakowski Labs
☑️ >130 peer reviewed publications, including in Nature, Nature Neuroscience, Neuron, and Lancet Neurology

"I've had the rare opportunity to get to know Ethan as both a surgeon and a basic scientist," said mentor Daniel Lim, MD, PhD. "He has this incredible ability to multitask at an impressive level, providing a truly exceptional level of care to our patients and contributing to many research projects, including his own NIH-funded fellowship."

Read more about Dr. Winkler's accomplishments: https://neurosurgery.ucsf.edu/news/neurosurgery-department-celebrates-residency-program-graduates-2021

Photos from UCSF Department of Neurological Surgery's post 06/23/2021

Congratulations to graduating chief resident Michael Safaee, MD, who will be starting a spine fellowship in the Department of Orthopedic Surgery at Johns Hopkins Medicine! 🎉🎓

Pictured here, Dr. Safaee at a hands-on cadaver workshop, and later with mentor UCSF Health neurosurgeon and spine expert Christopher Ames, MD. Dr. Safaee's favorite procedure? Pedicle subtraction osteotomy and minimally invasive transforaminal lumbar interbody fusion.

"I was struck immediately by how huge his heart was, how much he cared about patients, how ethical he was, and his extremely strong work ethic with clinical care and research," said Dr. Ames. "He grew into an incredible surgeon, and I couldn't be more proud."

Dr. Safaee's research highlights include
✅ 101 peer reviewed publications, including 30 in tumor and spine deformity
✅ Nominated for the 2021 Hibbs Award, the most prestigious recognition offered by the Scoliosis Research Society

"Mike was never afraid to take on projects that were really high risk and would not necessarily pay immediate dividends," said Dr. Ames. "I'm really impressed with his fearlessness with research."

Read more about Dr. Safaee's accomplishments: https://neurosurgery.ucsf.edu/news/neurosurgery-department-celebrates-residency-program-graduates-2021

Photos from UCSF Department of Neurological Surgery's post 06/21/2021

Congratulations to graduating chief resident Andrew Chan, MD, who will be starting a spine fellowship at Duke Neurosurgery with Christopher Shaffrey, MD! 🎉🎓🎊

Pictured here, Dr. Chan during a thoracic spine tumor resection with mentor UCSF Health neurosurgeon Praveen Mummaneni, MD. Together, they've completed 203 cases. Dr. Chan's favorite procedure? Thoracic pedicle subtraction osteotomy.

"Congratulations to an extraordinarily talented surgeon and a superb friend. Wish you all the best in the years ahead," said Dr. Mummaneni. "The future is bright!"

Dr. Chan's research highlights include
✅ Identifying patient-specific factors that portend the best results following surgery, using prospective longitudinal spine registries
✅ Investigating the effect of pulsed electromagnetic fields on experimental models of disc degeneration and disc herniation
✅ 49 shared publications with mentor Dr. Mummaneni
✅ Over a dozen research awards, including the Stewart Dunsker Award for Best Clinical Spine Abstract at the 2021 AANS Annual Scientific Meeting

Read more about Dr. Chan's accomplishments: https://neurosurgery.ucsf.edu/news/neurosurgery-department-celebrates-residency-program-graduates-2021

Next-Generation T-Cell Therapeutics Set Sights on Cancers, Autoimmune Disorders and More 06/18/2021

Next-Generation T-Cell Therapeutics Set Sights on Cancers, Autoimmune Disorders and More

"T cells are potent, diverse and circulate in every tissue from your head to your toes. They play a fundamental role in maintaining a healthy human body."

Read more about next-generation T cell therapeutics for glioblastoma and other diseases ➡️ https://www.ucsf.edu/news/2021/06/420841/next-generation-t-cell-therapeutics-set-sights-cancers-autoimmune-disorders-and

Next-Generation T-Cell Therapeutics Set Sights on Cancers, Autoimmune Disorders and More T cells – immune cells that patrol our bodies in search of trouble – have become a central focus for UC San Francisco scientists working on living cell therapies, an approach that views cells themselves as a form of medicine.

Photos from UCSF Department of Neurological Surgery's post 06/18/2021

"Follow your passion, and when it’s something you’re passionate about, don’t let other people discourage you. Because if it’s something that you absolutely love, it doesn’t seem like work."

Read UCSF Muriel Steele Society's interview with UCSF Health neurosurgeon Doris Wang, MD, PhD: https://murielsteelesociety.ucsf.edu/spotlights/muriel-steele-spotlight-interview-doris-wang.aspx

06/17/2021

Incredibly proud to celebrate our graduating chief residents Andrew Chan, MD, Michael Safaee, MD, and Ethan Winkler, MD, PhD! It's been an honor to train these three talented, hard-working individuals for the last 7 years. We look forward to the many future successes in their careers. 🎉🎉

Watch highlights from their virtual graduation ceremony ➡

Cellular Transplant Therapy Pioneered by UCSF Reverses Sea Lion’s Epilepsy 06/15/2021

Cellular Transplant Therapy Pioneered by UCSF Reverses Sea Lion’s Epilepsy

Nearly 9 months later and Cronutt still hasn't had a single seizure. Read the incredible story of Cronutt the sea lion, UCSF's Baraban Lab, and the world's first interneuron cell transplant treatment in a higher mammal. https://www.ucsf.edu/magazine/cellular-transplant-therapy-pioneered-ucsf-reverses-sea-lions-epilepsy

Cellular Transplant Therapy Pioneered by UCSF Reverses Sea Lion’s Epilepsy Cronutt was one sick sea lion before undergoing a groundbreaking surgery last fall. Today he's seizure-free and doing well.

As Prescribed: New Way Of Measuring Brainwaves Could Be Life-Changing For Parkinson's Patients 06/11/2021

As Prescribed: New Way Of Measuring Brainwaves Could Be Life-Changing For Parkinson's Patients

"This technology allows us not only to understand [patients'] brain activity much better, in a personalized way, but also to improve deep brain stimulation by making it adjust to exactly what the brain needs at any time."

Listen to UCSF Health neurosurgeon Philip Starr, MD, PhD on KCBS Radio's As Prescribed, as he discusses new technology for sensing abnormal brain activity, and delivering therapeutic brain stimulation to alleviate symptoms, for example in Parkinson's Disease.

https://www.audacy.com/kcbsradio/podcasts/as-prescribed-47294/as-prescribed-new-way-of-measuring-brainwaves-could-be-life-changing-for-parkinsons-patients-446231250

As Prescribed: New Way Of Measuring Brainwaves Could Be Life-Changing For Parkinson's Patients Researchers At UCSF Are Studying A New Technique For Measuring Brainwaves That Could Change The Way Diseases, Including Parkinson’s, Are Treated. For More, KCBS Radio's Kathy Novak Discussed With Dr. Philip Starr, Professor Of Neurological Surgery At UCSF, On "As Prescribed."

Timeline Photos 06/10/2021

On the front page of Nature Communications! The Baraban Lab uses CRISPR to generate 40 zebrafish lines, for in vivo analysis of single-gene mutations of catastrophic childhood epilepsy.

Read the open access publication ➡ https://www.nature.com/articles/s42003-021-02221-y
Explore the open-source database ➡ https://zebrafishproject.ucsf.edu/

On the front page of Nature Communications! The Baraban Lab uses CRISPR to generate 40 zebrafish lines, for in vivo analysis of single-gene mutations of catastrophic childhood epilepsy.

Read the open access publication ➡ https://www.nature.com/articles/s42003-021-02221-y
Explore the open-source database ➡ https://zebrafishproject.ucsf.edu/

Videos (show all)

BarabanS_iScience_20210630.mp4
UCSF Neurosurgery Community Internship Programs
Supporting Brain Tumor Research at UCSF - Diaz Lab
AVM Bleeding in a Young Brain: Angiography as Part of the Solution
Supporting Research at the UCSF Brain Tumor Center
Removal of a Brainstem Cavernous Malformation
Residents_MeetPD_TheolopolousP_2020_v4.mp4

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400 Parnassus Ave, 8th Floor
San Francisco, CA
94143
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