05/26/2026
Do male fertility supplements actually work?
The MOXI trial, one of the largest and most rigorous studies ever conducted on antioxidants and male infertility, set out to answer that question. Researchers across 9 U.S. fertility centers, including UCSF CRH physicians Dr. Marcelle Cedars and Dr. James Smith, studied whether common antioxidant supplements improved s***m health, pregnancy rates, or live birth outcomes in couples with male factor infertility.
The result: antioxidant supplements did not significantly improve s***m motility, morphology, DNA fragmentation, pregnancy rates, or live birth rates compared to placebo.
Why does this matter?
Because fertility care should be guided by evidence, not marketing.
Male fertility is complex and highly individualized. While lifestyle changes and targeted treatments may help some patients, this study showed that over-the-counter antioxidant combinations are not a universal solution for male factor infertility.
At UCSF CRH, we believe patients deserve transparent, research-driven care grounded in the latest science.
Send this to someone navigating fertility questions or trying to make sense of all the supplement advice online.
Study: The MOXI Randomized Clinical Trial