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Monday 8am - 5pm Tuesday 8am - 5pm Wednesday 8am - 5pm Thursday 8am - 5pm Friday 8am - 5pm

QBI

Quantitative Bioscience Institute (QBI) - QBI is the institute which transforms our understanding of biology and disease through quantitative research.

lnk.bio/qbi_ucsf The Quantitative Biosciences Institute (QBI) fosters collaborations across the biomedical and the physical sciences, seeking quantitative methods to address pressing problems in biology and biomedicine. Motivated by problems of human disease, QBI is committed to investigating fundamental biological mechanisms, because ultimately solutions to many diseases will be revealed by new discoveries in the basic sciences.

11/10/2025

New findings show that the APOE4 gene, a major risk factor for Alzheimer’s, affects the health of nerve cells by altering lysosomes, the cellular recycling hubs.

In APOE4 neurons, lysosomes are less acidic and less effective, caused by changes to the proteins TMED5 and LGALS3BP. This early cellular change could be critical in disease development.

Tap the link in bio to read the full study led by Einar Krogsaeter & Danielle Swaney and learn more about these cellular pathways.

11/07/2025

What happens when a chromosome breaks and how do cells put it back together? 🧬

Join us for a QBI seminar with Dr. James Haber of Brandeis University, who will share how scientists learned to watch DNA repair in real time and what that reveals about how cells maintain genetic stability.

🗓️ November 14, 2025
📍 UCSF Mission Bay - Mission Hall, Room 1401
🤝 Hosted by Nevan Krogan
✅ Learn more and register: link in bio.

11/06/2025

Join us for a seminar featuring Dr. Rafael Couñago of The University of North Carolina on November 13 at University of California, San Francisco! Learn about his perspective on how open data and AI models are accelerating chemical probe discovery as part of the Target 2035 initiative.

With over 20 years of experience in protein biochemistry and structural biology, Dr. Couñago’s work bridges chemical biology, structural approaches, and computational chemistry to uncover new therapeutic opportunities.

Learn more and register for his talk: link in bio.

11/05/2025

QBI Seminar: From Knowledge-Based Modeling to AI-Guided Discovery

How can AI and structural bioinformatics come together to reveal how genetic variation shapes protein function and ultimately, human health?

Join us Tuesday, November 12 at UCSF Mission Bay for a seminar with Dr. Arun Prasad Pandurangan, Assistant Research Professor in the Department of Medicine at the University of Cambridge, hosted by Andrej Sali.

Dr. Pandurangan develops computational tools that merge structural bioinformatics, molecular modeling, and genomics to understand how genetic variation influences protein structure and function. His research bridges classic structure-guided methods with AI and machine learning.

🔗 Learn more & register: Link in bio!

10/29/2025

Science thrives on collaboration!

Weicheng Li studies how small molecules and other tools can “rewire” cellular processes — part of a collaborative effort to better understand cancer biology through QBI’s Cancer Cell Mapping Initiative.

Watch the full clip on QBI TV to learn more about his work: link in bio.

10/28/2025

How do cells control what enters and exits the nucleus?

A new study unveils the most detailed map yet of the nuclear pore complex (the gateway between a cell’s nucleus and its cytoplasm), solving a decades-old mystery and shedding light on diseases like cancer, Alzheimer’s, and ALS.

This work was a collaborative effort among teams at Hebrew University of Jerusalem, UCSF’s QBI—with Andrej Sali as senior author—The Rockefeller University, and Albert Einstein College of Medicine.

Read the full study in PNAS: link in bio!

10/27/2025

Driven by personal experience, Dr. Verima Pereira is working to understand how liver cancer patients respond to therapy — and how biomarkers can help predict outcomes.

Through QBI’s Cancer Cell Mapping Initiative, she’s using systems biology to connect insights to impact. 🩵

Visit QBI TV to watch the full clip! Link in bio.

10/24/2025

We look forward to welcoming Dr. Andy Kilianski, Program Manager at ARPA-H for a seminar hosted by James Fraser!

Learn about how ARPA-H is investing in bold, transformative research to shape the future of health in the United States.

Register & save a seat: link in bio!

10/20/2025

Every tumor looks different - but cancer often affects the same key pathways 🧬 
Hear from Dr. Marcus Kelly (UCSD) on how his work with the Cancer Cell Mapping Initiative is helping scientists make sense of cancer at the systems level.

Visit QBI TV to watch the full clip! Link in bio. 

10/15/2025

Cancer research has come so far — from chemo to precision medicine 🔬✨ 
Hear from Dr. Nadia Arang on why she believes this is a pivotal moment for the future of cancer treatment.

Visit QBI TV to watch the full clip! Link in bio.

09/11/2025

The HARC Center awards Mentored Scientist and Collaborative Developmental Awards to encourage scientists pursuing HIV-related research and provide opportunities for training and career growth.

Check out this year’s awardees and the projects they’re working on! 🔬✨ link in bio.

08/14/2025

Join us on August 19 to commemorate emerging talent in science at the QBI Internship Symposium!

UCSF interns will take the stage to share their journeys into research and present highlights from their summer projects. From molecular biology to computational modeling, these presentations will spotlight fresh perspectives and discoveries across a wide range of basic and discovery science.

Check out our speaker line up and register for a chance to connect, celebrate, and support the next generation of researchers!

Link in bio.

Address

1700 4th Street
San Francisco, CA
94158

Opening Hours

Monday	8am - 5pm
Tuesday	8am - 5pm
Wednesday	8am - 5pm
Thursday	8am - 5pm
Friday	8am - 5pm

Telephone

(415) 476-6109

Website

http://qbi.ucsf.edu/

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The Quantitative Biosciences Institute (QBI) fosters collaborations across the biomedical and the physical sciences, seeking quantitative methods to address pressing problems in biology and biomedicine. Motivated by problems of human disease, QBI is committed to investigating fundamental biological mechanisms, because ultimately solutions to many diseases will be revealed by new discoveries in the basic sciences.