Pacific Neuroscience Institute

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Pacific Neuroscience Institute

Comprehensive Neurological Care, All in One Place, Focused on You. Our Linktree: https://shorturl.at/QIKQa We are a site for several clinical trials.

The Pacific Neuroscience Institute located at the John Wayne Cancer Institute and Providence Saint John's Health Center specializes in the treatment and care of patients with pituitary, brain and skull base tumors and other neurological disorders. Founded by Dr. Daniel Kelly, PNI emphasizes patient specific care with leading-edge minimally invasive surgical techniques and instrumentation. Our Research Center collaborates closely with scientists at the John Wayne Cancer Institute conducting research in basic science, preclinical research and translational research studies. Education is a high priority at our institute, where we train top surgical fellows in endoscopic and minimally invasive surgery. We also routinely participate in community outreach programs at local and national circles.

12/15/2025

A new MRI-based study presented at RSNA 2025 shows a clear link between body composition and brain aging. Higher muscle mass and lower visceral fat were associated with younger-appearing brains, while subcutaneous fat showed no connection to brain age.

Led by senior author Cyrus Raji, M.D., Ph.D., the multi-institutional research includes work from Pacific Neuroscience Institute physicians Somayeh Meysami, M.D., and David A. Merrill, M.D., Ph.D., highlighting PNI’s role in advancing research focused on physical and brain health.

These findings reinforce the importance of preserving muscle while reducing hidden abdominal fat to support long-term cognitive health and lower Alzheimer’s disease risk.

Learn more about the research shaping the future of brain health by clicking the link below.

https://www.rsna.org/media/press/2025/2614

12/12/2025

What is your strategy for staying healthy this holiday season? 🎄

The holidays can sometimes make it harder to stick to healthy habits — from busy schedules to changes in routine — but that doesn’t have to be the case.

In this blog, we share 4 simple ways to enjoy the festive season while still supporting your wellbeing. From navigating the grocery store to the power of a 10-minute meditation, these practical tips can help you feel more balanced through the end of the year. 💪

Click the link below to learn more.

https://www.pacificneuroscienceinstitute.org/blog/brain-health/4-healthy-holiday-tips/

12/11/2025

Holiday demands can be especially challenging for people managing pituitary disorders. Stress affects hormone balance, and even enjoyable events may feel harder to handle.

Checking in with how you feel, setting realistic limits, and communicating your needs can support better health during the season.

At Pacific Neuroscience Institute, we understand the real-life challenges that come with pituitary conditions and provide care that supports the whole person.

Read our blog, Holiday Success and the Pituitary, for practical tips on navigating stress during the season. Link below.

https://www.pacificneuroscienceinstitute.org/blog/pituitary-disorders/holiday-success-and-the-pituitary-2/

12/11/2025

Is it time to redefine the "Standard of Care" for Alzheimer's?

New brain health research argues that Multidomain Therapy must become the new gold standard.

After reviewing 23 prospective trials, the data show that targeting multiple biological systems (like inflammation and metabolism) yields effect sizes greater than unimodal therapies, including pharmaceuticals alone.

The Conclusion: Effective treatment requires a comprehensive approach where multidomain interventions are employed widely, early, and first-line.

Co-authors PNI's Dr. Jennifer Bramen and her colleagues say, “Alzheimer’s disease is far too complex for single-target solutions. Multidomain approaches offer a better path forward. Our review shows why they matter for anyone working to improve patient care."

Learn more by clicking the link below.

https://link.springer.com/article/10.1186/s13024-025-00912-2

12/10/2025

Dr. Marcus D. Mazur brings leading expertise in spinal care to patients through precise evaluation, innovative treatment options, and advanced surgical approaches.

His commitment to improving mobility, reducing pain, and enhancing long-term outcomes is helping patients return to active, fulfilling lives with confidence.

🎧 Listen to this episode on your favorite podcast platform.⁠

12/09/2025

Join us today at 12:30 PM PT for Grand Rounds.

Constantinos Hadjipanayis, MD, PhD, will present on integrating data streams in the O.R. for brain tumor surgery with moderation by Walavan Sivakumar, MD, and Garni Barkhoudarian, MD.

This month’s Grand Rounds also offers CME credit—be sure to sign in with your full name to receive credit.

Zoom Meeting Information:

💙 Link: https://zoom.us/join

💙 Webinar ID: 895 4586 0279

💙 Passcode: 90503

12/08/2025

New research in PNAS Nexus highlights a critical link between the oral microbiome and Alzheimer’s risk.

Discussing these findings, PNI’s Dr. Jennifer Bramen, Director of Neuroimaging, notes that while certain oral bacteria are linked to cognitive decline, others actually support memory.

The Key Takeaways:

The Connection: Higher levels of "good" bacteria (Neisseria and Haemophilus) correlate with better attention and memory retention.

The Action Plan: Dr. Bramen recommends a diet rich in nitrate-heavy vegetables to suppress harmful pathogens and support brain health.

Learn more by reading the full article here: https://shorturl.at/1oaJz

12/05/2025

Dr. Marcus Mazur has opened a new PNI spine clinic in Santa Monica. Dr. Mazur is a highly skilled and experienced board-certified fellowship-trained spine neurosurgeon.

His clinical practice focuses on adult spinal surgery for disorders of the cervical, thoracic, and lumbar spine. He is a recognized expert in the treatment of adult spinal deformity, complex revision surgery, spinal oncology, and minimally invasive spine surgery.

For patients wishing to schedule a consultation, contact us at 310-582-7450.

2125 Arizona Ave, 2nd Floor, Santa Monica, CA 90404

12/05/2025

Join us next week on Tuesday at 12:30 PM PT for Grand Rounds.

Constantinos Hadjipanayis, MD, PhD, will present on integrating data streams in the O.R. for brain tumor surgery with moderation by Walavan Sivakumar, MD, and Garni Barkhoudarian, MD.

This month’s Grand Rounds also offers CME credit—be sure to sign in with your full name to receive credit.

Zoom Meeting Information:

💙 Link: https://zoom.us/join

💙 Webinar ID: 895 4586 0279

💙 Passcode: 90503

12/04/2025

New data from CREST-2 show that for people with severe carotid artery narrowing but no recent stroke symptoms, adding a minimally invasive stent procedure to intensive medical therapy cut stroke risk by more than half compared with medical therapy alone.

Over four years, just 2.8% of patients who received stenting + medical care experienced a stroke — versus 6.0% of those on medical treatment alone.

The results are being hailed as a milestone for stroke prevention, offering new hope for patients at high risk of carotid stenosis and strengthening the case for stenting under the right conditions.

Click the link below to learn more.

https://vascularnews.com/historical-crest-2-data-show-reduced-stroke-risk-with-carotid-stenting-versus-medical-therapy-alone/

12/04/2025

At Pacific Neuroscience Institute, collaboration and curiosity drive every advancement in neurosurgery.

In our blog, international neurosurgeon observer Artur Rizer reflects on his two-month experience under the mentorship of Dr. Garni Barkhoudarian and the PNI neurosurgical team.

From morning rounds to complex skull base surgeries, he gained a firsthand look at the precision, teamwork, and dedication that define patient-centered care.

Click the link below to read the full article to learn how mentorship and hands-on learning continue to shape the next generation of neurosurgeons.

Article: https://www.pacificneuroscienceinstitute.org/blog/neuroscience-research/neurosurgery-observership-experience-precision-mentorship-at-pni/

⁠

12/03/2025

Precision in the operating room comes from more than surgical skill. ⁠

In this PNI Minute from the Quantum Leadership Podcast, Daniel F. Kelly, MD, reflects on how great surgeons balance courage with careful decision-making—respecting anatomy, knowing limits, and centering each patient’s needs. ⁠

This clip is part of a larger conversation with host Dr. Stephen Sideroff about leadership under pressure—from building a groundbreaking neuroscience institute to performing high-stakes brain tumor surgery where every millimeter matters. ⁠⁠

🎧 Listen to this episode on your favorite podcast platform.⁠

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2125 Arizona Avenue
Santa Monica, CA
90404

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http://www.pacificneuro.org/

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