09/09/2025
“Salmon s***m in skincare?” Yes — but here’s the science behind the headline.
The key ingredient is polydeoxyribonucleotide (PDRN), a DNA-derived compound that’s showing promising results in skin rejuvenation:
1. Improves elasticity, hydration & texture
2. Reduces pigmentation & wrinkle depth
3. Supports collagen remodeling & antioxidant defense
Mechanistically, PDRN works by modulating autophagy, upregulating SIRT1, and remodeling the extracellular matrix, which all contribute to healthier, more youthful-looking skin.
Both preclinical and clinical studies support its benefits, though ongoing research is needed to refine its role in aesthetic medicine.
As featured in Allure, this emerging treatment is gaining attention — not just for the buzzworthy origins, but for the evidence behind it.
Sources: Chen et al., PloS One, 2025; Kim et al., Molecules, 2022; Lee et al., Int J Mol Sci, 2024.
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