09/21/2020
⚙️ MAST CELLS ⚙️
Our immune system is made up of many cell types with mast cells being one of them. They have function across our entire bodies: Central Nervous System (CNS), Skin, Respiratory, Cardiovascular, GI, Menstrual, etc.
As the oldest of the white blood cell lines, they of course aid in immune support and combating foreign pathogens, especially parasites. They aid in the development of immune tolerance and adaptive defense as well as autoimmunity. They assist in wound healing, tissue development and remodeling, fat metabolism, and other pathways.
However, chronically elevated mast cell activation (called Mast Cell Activation Syndrome or Disease MCAS/MCAD) have less ideal downstream effects.
These immune cells release many compounds, including histamines, which we all know from the example of seasonal allergies which cause runny nose, sneezing, itchy and watery eyes. But the release of histamines isn’t just in the Respiratory system, it’s across all of the systems I mentioned above:
⚙️ CNS: headaches, nausea, vertigo, irritability, anxiety, depression, cognitive dysfunction, thermal dysregulation (aka inability to maintain core temperature), etc
⚙️ Skin: itching, hives, heat, flushing, pain, swelling tenderness, etc
⚙️ Respiratory: wheezing, shortness of breath, mucous production, bronchoconstriction, etc
⚙️ Cardiovascular: tachycardia (elevated heart rate), orthostasis (low blood pressure when going from sitting/laying down to standing up), dysrhythmia, etc
⚙️ GI: nausea, cramps, leaky gut, constipation, loose stools, food sensitives, dysbiosis, etc
⚙️ Menstrual: PMS, pelvic pain, endometrosis, etc
bryant and I are going live tomorrow, Tuesday September 22nd, 2020 at 5pm to talk more about the activation of mast cells and their particular role in GI health. Set a reminder and tune in for our chat! 💥
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