Advanced Age Management

08/08/2025

Your legs are literally training your brain.

Researchers followed 324 identical twins for 10 years and discovered the twins with stronger legs consistently had better brain function a decade later, despite sharing identical DNA.

The stronger twin had more gray matter, larger brain volume, and significantly less cognitive decline. Just a 40-watt increase in leg power led to an 18% improvement in brain performance, equivalent to being 3.3 years younger cognitively.

Here’s why this matters: your legs contain your largest muscle groups and demand the most oxygen. When you strengthen them, you force increased blood flow and growth factors directly to your brain.

Simple activities like walking, taking stairs, or bodyweight squats triggered these brain-protective effects. Your legs are actively preventing brain atrophy and promoting new neuron growth.

While you can’t change your genes, you can change your leg strength. Start simple!! Your neurons are counting on it.

DOI: 10.1159/000441029

08/08/2025

08/08/2025

You might not expect it, but supporting your GLP-1 levels naturally is both doable and effective.

Here’s what I recommend: Focus on eating more fiber and protein, move your body after meals, get quality sleep, manage stress, and nurture your gut microbiome.

These simple steps work together to help your body produce GLP-1 on its own. 

Your health is shaped by the choices you make every day. Start with one or two and build from there.

08/08/2025

Changes in how brain cells generate energy may drive the development of Alzheimer's disease and influence how patients respond to therapy, according to a new study from Mayo Clinic researchers. The findings spotlight mitochondrial complex I — a critical component of cellular energy production — as both a contributor to disease progression and a promising target for new treatments.

Learn more: https://mayocl.in/4foAY8V

08/06/2025

Semaglutide was approved in 2017 as an injectable diabetes; there are several preliminary studies researching if it can protect against dementia.

08/06/2025

Learn what biological age is, how you can measure it — and what you can do to increase it.

08/06/2025

08/05/2025

Interesting finding to explain why some people don't respond as well to the GLP-1 medications as the majority of patients.

Your genetics may play a role in how you respond to GLP-1 medications.
Our researchers identified a gene that could help predict who is more likely to successfully lose weight with these drugs.
Medications like semaglutide help many people lose weight successfully, but results vary widely.
Our researchers found people with a "responsive" neurobeachin (NBEA) gene score were up to 120% more likely to lose more than 10% of their weight with semaglutide.
The findings were published in Diabetes, Obesity and Metabolism.
This discovery could lead to a tool enabling medical providers to identify the most effective weight loss interventions based on a person's genetic makeup.

08/04/2025

“Eating this ultraprocessed food may be good for you and the planet,” says CNN.
Right. And drinking Diet Coke is hydration.

Let me explain what’s actually happening when you ingest these products:

A Beyond Burger contains ~20+ engineered ingredients: pea/soy protein isolates (often extracted with solvents like hexane), methylcellulose (the same thickener used in wallpaper paste that your body can’t digest), “natural flavors” (a catch-all for lab-created compounds companies don’t have to disclose), cultured dextrose (a fermentation product that can include MSG-like compounds), and modified starches (chemically altered fillers).

Impossible adds soy leghemoglobin, a GMO yeast–derived “bleeding” agent that wasn’t in the human food supply before 2019.

When these hit your system, your body responds like it does to any ultra-processed food: inflammatory cascades, blood-sugar dysregulation, and gut-microbiome disruption. Your metabolism doesn’t magically treat a plant patty differently because the label says “plant-based.”

Quick label check: If it needs a lab to make it, a paragraph-long ingredient list to explain it, or words like isolates, modified starches, gums, or “natural flavors,” it’s ultra-processed. Real food reads like a recipe, not a chemistry set.

Don’t believe every headline. These are still ultra-processed foods… they hit your metabolism like a Cheeto with better PR.

If you’re plant-based, stick to actual plants: vegetables, legumes, nuts, seeds, olive oil, herbs, and minimally processed staples. If you eat meat, choose regeneratively raised options.

Your body has evolutionary wisdom about real food. Trust it over marketing headlines.

08/04/2025

You’re never too old to start building muscle.

Muscle acts as a metabolic reservoir, storing and utilizing glucose efficiently, preventing insulin resistance, and protecting against chronic disease.

The study found that muscle mass (not BMI) was the strongest predictor of survival, independent of fat mass, cardiovascular risk factors, and metabolic markers.

I used to think lifting weights was just for bodybuilders, I didn’t love the gym and thought cardio was enough.

But when I learned that strength training activates longevity pathways like mTOR and AMPK, protects mitochondria, and triggers the release of myokines (hormone-like compounds that reduce inflammation and enhance brain function) I realized it wasn’t just about looking fit.

It was about living longer, stronger, and healthier.

DOI: 10.1016/j.amjmed.2014.02.007