02/26/2026
How the Nervous System Influences Cancer—Beyond the Brain
Emerging clinical and translational research shows that the nervous system not only communicates within the brain and spinal cord—it also directly interacts with tumors throughout the body.
A review published in Oncogene by Weihan Li and colleagues explains how nerves outside the central nervous system actively shape the cancer microenvironment, influencing how tumors grow, spread, and respond to stress signals.
Peripheral nerves release neurotransmitters and neuropeptides—such as norepinephrine, acetylcholine, and substance P—that can act directly on cancer cells and surrounding immune cells.
These signals have been shown to affect tumor cell proliferation, angiogenesis (new blood vessel formation), immune suppression, inflammation, and metastatic potential.
The nervous system also communicates bidirectionally with the immune system. Stress-related sympathetic signaling can alter immune cell behavior within the tumor microenvironment, reducing anti-tumor immune surveillance and promoting a pro-inflammatory, tumor-supportive state.
Conversely, parasympathetic and regulatory neural pathways may influence tissue repair, immune balance, and metabolic signaling in ways that affect tumor biology.
Cancer does not develop in isolation. It exists within a complex ecosystem that includes immune cells, blood vessels, metabolic signals—and the nervous system.
If you are navigating cancer and want to understand how your nervous system, metabolism, and inflammation may influence healing, we are here to support you. www.KatallageWellness.com
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