Lewis Drug

Lewis Drug You’ll find a huge selection of name brands and specialty items, all at affordable prices.

Grab all your everyday essentials from groceries and prescriptions to home decor and beauty supplies at your Sioux Falls Lewis, located at 41st Street and Marion Road. Find everything you need and a few unexpected finds in departments like Health & Beauty, Grocery, Pets, Wine & Spirits, Lawn & Garden and more.

Save $5 instantly when you spend $25 on Halloween decor with the Lewis app (excludes pumpkins, live goods, and Halloween...
09/27/2025

Save $5 instantly when you spend $25 on Halloween decor with the Lewis app (excludes pumpkins, live goods, and Halloween candy). Stock up on frightful finds and set the scene for Halloween night.

Breathe easier and save. Allegra Allergy 30+10-ct. tablets now $19.97, compare to $21.99 and save $2.02. Discover this d...
09/27/2025

Breathe easier and save. Allegra Allergy 30+10-ct. tablets now $19.97, compare to $21.99 and save $2.02. Discover this deal and more in our latest Weekly Ad. Available from September September 24 to 30. Don’t miss out!

www.lewisdrug.com/weekly-ad

Lewis is having its final patio clearance of the year. Save up to 80% off original prices! Display units only, while qua...
09/26/2025

Lewis is having its final patio clearance of the year. Save up to 80% off original prices! Display units only, while quantities last. Selection varies by location. Find the perfect set before it’s gone for the season!

Stock up and save. Buy one Mason Vitamins, get one free of equal or lesser value. Discover this deal and more in our lat...
09/26/2025

Stock up and save. Buy one Mason Vitamins, get one free of equal or lesser value. Discover this deal and more in our latest Weekly Ad. Available from September September 24 to 30. Don’t miss out!

www.lewisdrug.com/weekly-ad

Tackle fall cleanup with ease. Lewis lawn & leaf bags, 5-pack, now only $2.99. Discover this deal and more in our latest...
09/25/2025

Tackle fall cleanup with ease. Lewis lawn & leaf bags, 5-pack, now only $2.99. Discover this deal and more in our latest Weekly Ad. Available from September September 24 to 30. Don’t miss out!

www.lewisdrug.com/weekly-ad

Enter to win a free $25 Lewis Gift Card for your pet! Simply upload your pet’s photo and name to THIS post and a weekly ...
09/24/2025

Enter to win a free $25 Lewis Gift Card for your pet! Simply upload your pet’s photo and name to THIS post and a weekly winner will be chosen. To see if you’ve won, make sure you watch future Lewis posts on Facebook, released on Tuesdays. **Lewis employees and their immediate family members are not eligible to participate in this contest. This promotion is in no way sponsored, endorsed or administered by, or associated with Facebook.
View winners here: https://www.lewisdrug.com/categories/pets

Halloween decor is now 50% off original prices at Lewis (excludes pumpkins, live goods, and Halloween candy). Give your ...
09/23/2025

Halloween decor is now 50% off original prices at Lewis (excludes pumpkins, live goods, and Halloween candy). Give your space a festive touch just in time for the spooky season.

Join us for Senior Day at Lewis, happening today and every Tuesday! Seniors aged 55 and over can enjoy a 10% discount on...
09/23/2025

Join us for Senior Day at Lewis, happening today and every Tuesday! Seniors aged 55 and over can enjoy a 10% discount on everything* (*Exclusions apply: deal not available for to***co products, beer, wine & spirits, prescriptions, lottery tickets, or gift cards).

Fresh, locally grown pumpkins delivered to Lewis every week now available!
09/22/2025

Fresh, locally grown pumpkins delivered to Lewis every week now available!

Spend $25 on GoodSense products with the Lewis app and get $5 off your next GoodSense purchase. Discover this deal and m...
09/22/2025

Spend $25 on GoodSense products with the Lewis app and get $5 off your next GoodSense purchase. Discover this deal and more in our latest Weekly Ad. Available from September 17 to 23. Don’t miss out!

www.lewisdrug.com/weekly-ad

Happy first day of autumn!
09/22/2025

Happy first day of autumn!

Address

5500 West 41st Street
Sioux Falls, SD
57106

Opening Hours

Monday 8am - 9pm
Tuesday 8am - 9pm
Wednesday 8am - 9pm
Thursday 8am - 9pm
Friday 8am - 9pm
Saturday 8am - 9pm
Sunday 9am - 6pm

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