01/30/2026
This
The sober âReality Meets Scienceâ take on GLP lawsuits:
1) Benefits are real (and measurable).
For appropriate patients, GLP meds can meaningfully improve cardiometabolic risk, OSA, fatty liver, and quality of life. They can also be life-changing for satiety regulation and CRRAHP (calorie rich, refined and hyper palatable) âfood noiseâ.
2) But risks are real and must be discussed plainly. Most side effects are GI (nausea, constipation/diarrhea), but there are clinically meaningful risks that deserve clear informed consent and monitoring: dehydration, gallbladder disease risk, pancreatitis warning signals, worsening GERD, severe delayed gastric emptying symptoms, and rare but serious complications. (And yes, the media will amplify worst-case anecdotes â we can acknowledge them without generalizing.)
3) Lawsuits are not proof of causation - but they can surface legitimate safety gaps.
Litigation is about alleged warning/labeling/marketing failures and harms in individuals â it doesnât automatically mean the medication is âunsafeâ broadly. It does mean patients and clinicians should be extra rigorous about screening, counseling, and follow-up.
4) The ârightâ question isnât âGLPâs: good or bad?â
Itâs: Who is the right candidate, at what dose/titration speed, with what monitoring, and what long-term plan?
5) The long-term plan matters.
These meds work best as part of a system: protein adequacy, resistance training, fiber/whole foods, sleep, strength preservation, and a realistic maintenance strategy (including what happens if the med is stopped).
A practical âRMSâ checklist you can discuss with your licensed prescriber:
⢠Start low, titrate slow; donât race the dose.
⢠Protein + resistance training to protect lean mass.
⢠Hydration + electrolytes as needed; manage constipation proactively.
⢠Screen gallbladder history, pancreatitis risk, severe reflux/gastroparesis symptoms.
⢠Clear red flags: persistent vomiting, severe abdominal pain, inability to hydrate, black/tarry stool, fainting, vision changes â urgent evaluation.