01/23/2026
https://www.facebook.com/share/p/18DEgznWVC/
🧬 Niacin: The Methylation “Buffer” No One Talks About
Most people think methylation is just about adding more methyl donors
(methylfolate, methyl B12, SAMe).
But biology isn’t a gas pedal only — it needs brakes too.
That’s where Niacin (Vitamin B3) comes in.
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⚖️ Why Niacin Matters in Methylation
Niacin is methylated during metabolism, meaning it uses up excess methyl groups.
This makes it a natural buffer when methylation is running too fast.
That’s why, in some people, high-dose methylated B vitamins can cause:
• anxiety
• agitation
• insomnia
• “wired but tired” feelings
Niacin helps restore balance, not block methylation.
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🧠 Especially Relevant for MTHFR
People with MTHFR variants often struggle with methylation regulation, not just deficiency.
Niacin can act as a safety valve when methyl donors overshoot.
Balance > overload.
And niacin is one of the most overlooked tools for keeping that balance.