08/31/2025
Many people living with mold-related illness experience vasomotor symptoms — dizziness, flushing, swelling, temperature swings, or circulation changes. These aren’t random and they’re not “just anxiety” — they reflect real changes in how mold toxins affect blood flow, blood pressure, and the nervous system.
Here are some of the ways this can happen:
🔹️Low VEGF (Vascular Endothelial Growth Factor)
VEGF supports the growth of tiny blood vessels that bring oxygen to your tissues. When VEGF is low, oxygen delivery suffers — leading to fatigue, poor recovery, cold extremities, and even swelling (edema) from sluggish lymph and fluid movement.
🔹 POTS and Blood Vessel Response
Postural Orthostatic Tachycardia Syndrome (POTS) often appears in mold patients. The most common issue in POTS is that peripheral vessels (arms and legs) don’t constrict properly when standing, which allows blood to pool and causes dizziness or a racing heart.
-But in some mold patients, there’s a twist: the peripheral vessels may also have low sensitivity to nitric oxide (NO). Instead of dilating when they should, these vessels stay too tight. This can worsen circulation problems, contribute to cold extremities, and make blood pressure regulation even more unpredictable.
🔹 Immune System Autoantibodies
Sometimes the immune system produces antibodies against the very receptors that regulate vessel tone and heart rate. This can cause unpredictable shifts: elevated or low blood pressure, poor circulation, flushing, or lymphatic congestion.
🔹 Histamine-Mediated Responses
Mycotoxins can also trigger mast cell activation, releasing histamine, which directly affects blood vessels. This can lead to flushing, hives, swelling, temperature swings, and even sudden drops or surges in blood pressure. For many patients, histamine is a big driver behind the “rollercoaster” of vasomotor symptoms.
✨ The Bottom Line
Vasomotor symptoms in mold illness are not one-size-fits-all. One person may deal with low blood pressure, another with spikes in blood pressure, and others with swelling, flushing, or cold hands and feet. Understanding whether the vessels are failing to constrict, failing to dilate, or overreacting to histamine helps us tailor support and restore balance.
If you’ve been dealing with dizziness, circulation changes, or swelling in the context of mold exposure, know that there are answers — and support is possible.
At Rooted Wellness, we take the time to uncover the why behind your symptoms and create a plan that addresses the root causes — not just the surface. If this resonates with your story, we’d love to help you find your way back to balance and vitality.