02/26/2026
A new study from researchers at WashU Medicine, published in Science Translational Medicine, has identified lymphatic vessels and their cargo — a sugar molecule called hyaluronan (shown in pink in the second image) — as critical drivers of chronic rejection in transplanted lungs and hearts. A lung transplanted between genetically identical mice is laden with scar tissue full of hyaluronan (top half of second image). Following a treatment to promote growth of lymphatic vessels, hyaluronan accumulation is markedly reduced (bottom of second image).
“We are excited about this study because it reveals a previously unknown cause of chronic rejection that is independent of the immune response against foreign tissue, and our data show it may be treatable,” study senior author Daniel Kreisel, MD, PhD, said.
“WashU Medicine provides an extraordinary environment for collaboration — none of these discoveries would have been possible had any of our colleagues and their expertise been absent,” Hailey Shepherd, MD, a general surgery resident at WashU Medicine said.
Read more about the study here: https://bit.ly/3MWtmRg