01/06/2026
Here is an additional post that is too good not to share….it is from Chris Kresser:
“Recent neuroimaging research continues to support what Indigenous traditions have long intuited: psilocybin may help reset the brain's functional networks, particularly in people with low mood and emotional dysregulation.
A new study using magnetoencephalography (MEG) found that a single dose of psilocybin disrupted the rigid, over-connected brain activity patterns seen in persistent low mood and promoted more flexible, globally integrated neural dynamics. These changes weren't just immediate—they persisted for up to three weeks.
Participants with the greatest increase in connectivity also saw the biggest improvements in symptoms. The researchers suggest psilocybin may loosen entrenched patterns of brain signaling, opening a window for emotional and cognitive change.
It's not a magic bullet, but paired with the right therapeutic setting, it could offer a powerful opportunity for healing at the level of both biology and belief.”
https://www.nature.com/articles/s41593-025-02068-0?fbclid=IwY2xjawPJUElleHRuA2FlbQIxMQBzcnRjBmFwcF9pZBAyMjIwMzkxNzg4MjAwODkyAAEeg86lDvs1iBIZ0-kw4j2c0Pejq1wVVofrITSmFUOlLTUvExoJD9zbvwV9SkM_aem_2hbL8EBRGjjVSZ7kYGr1Tw
Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.