11/24/2025
I wanted to share another interesting talk that I had the opportunity to attend while at the Age Management Medical Group (AMMG) conference. The opening lecture for this conference was Dr. Eugene Shippen. This gentleman is still practicing (limited hours) well into his 80s. He gave an amazing lecture on the use of high dose Vitamin D for treatment of many autoimmune conditions as well as chronic Lyme's disease. His work is a variation of the Coimbra protocol. Dr Coimbra is a neurologist out of Sao Paulo Brazil and has been using high dose Vitamin D to treat MS and keep it remission. The premise behind this is there are individual doses of vitamin D that are supportive for the body. Now some will argue that high doses of vitamin D will contribute to calcification of the arteries (hardening of the arteries). In fact, the science behind this shows that low vitamin D levels, increase concentrations of parathyroid hormone (master regulator of calcium) which creates increases in calcium within the blood circulation. Higher serum 1,25-vitamin D levels were associated with lower amounts of vascular calcification. This is particularly startling to me as I see more facilities reporting "normal vitamin D levels" as being in a 30-60 range. Are we keeping ourselves sicker by not optimizing our vitamin D? Before you undertake increasing your vitamin D, please work with a knowledgeable provider to monitor your parathyroid hormone levels.
https://www.ahajournals.org/doi/10.1161/01.CIR.96.6.1755
https://pubmed.ncbi.nlm.nih.gov/33897704/
Vitamin D3 (cholecalciferol) is a secosteroid and prohormone which is metabolized in various tissues to the biologically most active vitamin D hormone 1,25(OH)2D3 (calcitriol). 1,25(OH)2D3 has multiple pleiotropic effects, particularly within th...