05/06/2026
The main cause of Osteoarthritis? It's NOT simply "wear & tear". ๐คฏ
Arthritis has often been thought of as a result of too much stress on a joint. As if there is some sort of pre-determined amount of steps, force, or repetitions allotted to joints. Though this is a contributing factor, we now know that it is mostly triggered and controlled by inflammation - regardless of the physical amount of stress on the joint.
Studies show much elevated levels of inflammatory markers in osteoarthritic (OA) joints (and even moreso in RA). One specific inflammatory protein, IL-6, has been found to be up to 109x more present in OA joints vs normal joints.
IL-6 is highly destructice to joints in many ways:
๐ฅ increases MMP proteins that destroy Type II Collagen & Aggrecan
๐ฅ induces RANKL which erode bone (osteoclasts)
๐ฅ stimulates VEGF which stimulates pannus (overgrowth of synovial tissue which degrades cartilage & bone)
๐ฅ inhibits Wnt signaling, blocking new bone growth while signaling destruction
IL-6 is also considered a major cause of arthritis pain.
IL-1 and TNF-a are also highly prevelant in OA tested joints. These inflammatory proteins degrade cartilage, reorganize the cartilage matrix, and may even lead to the increased bone growth (i.e.spurs) associated with OA. This cartilage damage then triggers more inflammation... and the cycle continues.
So, when you hear that the amout of stress or pounding to a joint is going to wear it down & lead to arthritis, remember, it is not such a direct cause & effect. It is not neccessrily a simple mechanical break down, strictly from load.
Wanna know more? Stay tuned throughout the month of May for my Arthritis Awareness Month educational series!
โค๏ธ, Kristen & the Prosper Team
"Preserving Active Lifestyles in Unconventional Ways"
