02/03/2026
Dr. Peter Osborne provides a comprehensive breakdown of Inositol (historically Vitamin B8), a nutrient that acts as a critical "secondary messenger" for your hormones and neurotransmitters. While the body can synthesize up to 4 grams of inositol daily, deficiencies are common and linked to chronic conditions like Hashimoto’s, PCOS, and metabolic syndrome.
Key Takeaways & Benefits:
• Thyroid Health (Hashimoto’s): Learn how combining Myo-Inositol with Selenium can lower high TSH levels and reduce TPO antibodies in autoimmune thyroid disease. Inositol is essential for the cellular signaling required to create T3 and T4 hormones.
• PCOS & Infertility: Discover why studies show Inositol is non-inferior to Metformin for regulating blood sugar and improving fertility in women with Polycystic O***y Syndrome, without depleting B12 or Folate.
• Anxiety & Panic Attacks: Dr. Osborne reviews a study where high-dose Inositol (18g/day) outperformed Fluvoxamine in reducing panic attacks with fewer side effects.
Insulin Resistance & Fatty Liver: Inositol is a second messenger for insulin; a deficiency is a known cause of non-alcoholic fatty liver disease and insulin resistance.
• Pregnancy Health: Supplementation helps prevent gestational diabetes and neural tube defects, particularly in women who are folate-resistant
Topics Covered:
• What is Inositol? Understanding its role as a "secondary messenger" in cell signaling.
• Food Sources: Meats, citrus (excluding lemon), melons, leafy greens, almonds, and peas.
• Inositol Depletors: How antibiotics, lithium, seizure medications, and coffee may lower your levels.
• Dosage Guide:
◦ Maintenance: ~1 gram/day.
◦ PCOS/Thyroid: 2–4 grams/day (Myo-inositol form recommended).
◦ Anxiety/Depression: Up to 18 grams/day (powder form recommended).
• Testing: Why intracellular testing is recommended to detect deficiency, which affects 15-25% of patients.
Scientific Concepts for Context:
• Cell Signaling: Hormones bind to receptors, and inositol delivers the message into the cell (e.g., to the endoplasmic reticulum) to regulate function.
• Iodine Organification: Inositol helps produce hydrogen peroxide, which is necessary to convert iodide into iodine for thyroid hormone production.
• Folate Resistance: Myo-inositol helps prevent neural tube defects in women who do not respond efficiently to folate alone.
Recommended Forms: Dr. Osborne recommends Myo-Inositol as the preferred form over IP6 or D-Chiro-Inositol, as it is the most abundant form the body naturally utilizes.
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Dr. Peter Osborne is one of the most sought after alternative and nutritional experts in the world. A Diplomate with the American Clinical Board of Nutrition, a graduate of Texas Chiropractic College, and a doctor of pastoral science, Dr. Osborne is one of the world’s leading authorities on gluten, nutrition, and natural health. He is the founder GlutenFreeSociety.org, one of the world's largest informational sites on gluten sensitivity. In addition, he is the author of the best selling book, No Grain No Pain, published by Touchstone (Simon & Schuster). His work has been featured by PBS, Netflix, Amazon, Fox, U.S. News, Ney York Post, and many other nationally recognized outlets.
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