10/16/2025                                                                            
                                    
                                                                            
                                            ONCOLOGY
Underlying Mechanisms Responsible for Spontaneous Cancer Regression
October 7, 2025
Spontaneous regression of cancer, notably in neuroblastoma, leukemia, lung cancer, and melanoma, is rare and poorly understood. Historical observations implicate infections and immune activation in tumor shrinkage. William B. Coley, a surgeon, pioneered immunotherapy by using bacterial toxins to induce fever and immune response. Modern research explores viruses and immune mechanisms. In a series of 54 leukemia cases, 76% of remissions were associated with bacterial infection and 45% with blood transfusion (median time, 5 months). Factors like infections, transfusions, and immune responses are linked to temporary remissions. Understanding these processes could inform future cancer treatments. 
The Takeaway: Understanding the underlying mechanisms for spontaneous tumor regression may guide new cancer therapies.
COMMENT: This is an interesting report that has just come out. General medicine has shown no interest in and has been strangely silent on this issue of spontaneous remission of cases with cancer. These remissions are looked upon as being curiosities rather than a phenomenon to be more widely understood.                                   As a result, funding and research have focused on chemotherapy, radiation, and surgical approaches rather than on also understanding cancer from a psychosomatic (mind-body) perspective. This can make valuable contributions to the care of patients with a cancer diagnosis who are, astonishingly, hardly ever offered psychological support. Such support has the potential to help patients have less pain, anxiety and a longer survival. At the same time, it needs to be said that psychological approaches need not and should not be used to replace the usual forms of treatment but rather to supplement it, so that the patient has the best of both worlds. The only work that I am aware of that talks about remissions from malignancy is a book by a Dr. Rediger called "Cured" which may be of interest.