06/11/2025
A recent study published in Radiology shows that corticosteroid injection caused significant progression of knee OA over 2 years, whereas HA injections did not.
210 patients were followed over 2 years, with MRI at baseline and @ 2 years. Subjects received either HA or CSI. Corticosteroid injections were associated with higher OA progression than HA injections and controls, whereas HA was associated with decreased progression at MRI for up to 2 years after injection.
With the advent of PRP and other orthobiologics, why are physicians continuing to inject osteoarthritic joints with corticosteroids? In fact, there is now more Level 1 research showing that PRP is effective for treating knee OA than for ANY OTHER non-surgical treatment.
However, as we are now learning, not all PRP is the same! Dose matters, and it appears that platelet dosing of 10 billion or greater results in significantly better clinical outcomes.
Thanks Dr. Goldwaser and Dr. Tortland for sharing.
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