08/28/2022
👁🗨 Editors' pick
Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease
Shah et al. show disrupted cingulate functional connectivity in mice and humans before amyloid deposition. Cingulate astrocytes demonstrate decreased calcium signaling, while neurons are hyperactive. Restoring the regulatory activity of astrocytes recovers neuronal hyperactivity, cingulate connectivity, and behavior deficits, suggesting that astrocytes represent a major player in early Alzheimer’s disease.
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