08/23/2022
We take great pleasure in sharing the excellent news that Dr. Beng San Yeoh (first author) and Dr. Matam Vijay Kumar, along with their lab members and both national and international collaborators have published in the journal Gastroenterology, the impact factor of which is 33.8.
In a nutshell, the study has uncovered a major vascular defect in a widely used experimental model in biomedical research (BL6 mice) as the KEY REASON for a subset of these mice to develop liver cancer in response to a dietary soluble fiber (inulin). Besides this vascular discovery, the study recommends screening of BL6 mice for high serum bile acids to identify ones with the newly discovered vascular defect and exclude them from experiments as they are major outliers for nutritional, metabolic, and immunologic studies.
https://www.gastrojournal.org/article/S0016-5085(22)00959-3/fulltext