Colibris Canna Consulting & Coaching

05/20/2025

Recent advances in cancer research have unveiled innovative strategies that cause cancer cells to destroy themselves. At Penn State University, scientists have developed a modular genetic circuit that turns cancer cells into “Trojan horses,” reprogramming them to initiate their own death while also eliminating surrounding drug-resistant cells. This technique has delivered promising results in lab-grown human cells and mouse models, offering a potential breakthrough in tackling cancer’s complexity and resistance to standard treatments.

Meanwhile, another team of researchers has designed a cutting-edge molecule to fight blood cancer by targeting the BCL6 protein—a key player in helping cancer cells evade death. By linking BCL6 with the BRD4 protein, this new compound reactivates suppressed cell death signals, triggering the cancer cells to self-destruct. This development introduces a powerful new class of cancer therapies with broad potential across various types of cancer.

02/19/2025

https://pmc.ncbi.nlm.nih.gov/articles/PMC4960344/?fbclid=IwZXh0bgNhZW0CMTEAAR1UHfixxrrf4uIuArRzqhFjuHbZSzEajV3vSJ6J36aRyGA8OzmRItauEh0_aem_zuSWUjcQVBvPNaK5_bBEGw

01/27/2025

Low-doses of THC, CBD, & CBG. . .

A study by the University of the Basque Country (UPV/EHU) demonstrates that the drug WIN55,212-2 protects the brain and reverses early cognitive damage caused by dementia, while also explaining its mechanism of action. Over two decades of research conducted by the Neurochemistry and Neurodegenera

01/14/2025

10/29/2024

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10/10/2024

. . . this is a real problem … 22 Vets a day surrender to their demons. May I please get 2 friends or family members (out of all my friends on my page) to copy & re-post? Someone’s life may depend on it.
call: 988

10/06/2024

We already knew this and that full-spectrum tends to work better, but these results are encouraging nonetheless in my opinion: "Results from the dronabinol group show . . . a 30% decrease compared to the scores in the placebo group which did not change. Additionally, dronabinol was well tolerated by patients compared to current treatments for agitation. 'Results like this are encouraging. We are thrilled that FDA-approved dronabinol was robustly effective and appeared safe for treatment of agitation,' says Rosenberg. 'This adds another tool in our efforts to improve the care of our loved ones with Alzheimer’s disease.'”

Patients tolerated synthetic THC (dronabinol) well, without the adverse effects commonly associated with existing Alzheimer's agitation medications. A study conducted by researchers from Johns Hopkins University School of Medicine and Tufts University School of Medicine found that a pill form of dr

09/19/2024

"Tumour mutational burden (TMB): Tumours with a high number of mutations tend to produce more neoantigens, making it easier for the immune system to recognize and attack them. TMB has been one of the most studied biomarkers for predicting response to CPIs.

Effective T-cell infiltration: The presence of cytotoxic T-cells in the tumor is essential for the effectiveness of CPIs. This study has confirmed that a higher infiltration of these cells is directly related to a better response to the therapy.

TGF-β activity in the tumor microenvironment: This factor influences the behavior of some cells in the tumor microenvironment. High TGF-β activity can suppress the immune response, which is reflected in a tendency for patients to have poorer survival after immunotherapy treatment.

Previous treatment: Patients who have received previous treatments tend to show a poorer response to immunotherapy.

Tumour proliferative potential: Patients with tumors that have a high proliferative index, which tends to be more aggressive, generally show poorer survival after treatment."

Researchers identified five factors that predict response to immunotherapy, advancing personalized cancer treatment. This could help target therapy more effectively, reducing unnecessary side effects. Immunotherapy has revolutionized cancer treatment by harnessing the immune system to target tumo

08/26/2024

"Scientists have discovered a protein that can directly halt DNA damage. Better yet, a new study shows it appears to be 'plug and play', theoretically able to slot into any organism, making it a promising candidate for a cancer vaccine."

Abstract. The bacterium Deinococcus radiodurans is known to survive high doses of DNA damaging agents. This resistance is the result of robust antioxidant

08/22/2024

“The NCAA drug testing program is intended to focus on the integrity of competition, and cannabis products do not provide a competitive advantage,” said Josh Whitman, chair of NCAA’s Division I Council and the athletic director at the University of Illinois. “The council’s focus is on policies centered on student-athlete health and well-being rather than punishment for cannabis use.”

In a groundbreaking move, the National Collegiate Athletic Association (NCAA) has announced that it will be removing cannabis from its list of banned substances. This significant policy change reflects a […]

08/15/2024

They found that a new cancer drug called eFT508, currently in clinical trials, blocks eIF4E and the ketogenic pathway, preventing the body from metabolizing fat. When the scientists combined the drug with a ketogenic diet in an animal model of pancreatic cancer, the cancer cells starved.""

Scientists at UC San Francisco have discovered a way to get rid of pancreatic cancer in mice by putting them on a high fat, or ketogenic, diet and giving them cancer therapy.

08/09/2024

"Part of the problem can be traced to the extensive cross-breeding that has occurred over time. So while the original indica plant, indigenous to the Middle East, might have differed genetically and chemically-speaking to its sativa cousin from central Asia, 'things are now too mixed up' for there to be a clear distinction, says Myles.

New and different labels
For better accuracy, researchers suggest that cannabis be classified according to its chemical, rather than physical, attributes. Every plant contains some 540 chemical substances, including more than 144 different cannabinoids—compounds such as THC and cannabidiol (CBD) that produce specific medicinal and psychoactive effects.

This alternative system would see labels listing the key compounds present in a particular cultivar, alongside their respective amounts—similar to the ‘Nutrition Facts’ panel found on food packages. ‘Ingredients’ would include cannabinoids and terpenes, another type of biologically active molecule produced by the plants."

Have you heard that sativa is an upper and indica is a downer? It's not quite that simple. Here's what cannabis research shows is really affecting your high.