11/10/2024
Eczema info & tips for Filipino Americans: 1️⃣ Allergies, eczema, & Filipinos: Filipinos were reported to have the highest risk for eczema compared to other Asian American groups. Filipinos were also reported to have the highest odds for allergy-related diseases, like asthma and food allergy. Scientists suggest that eczema is the first manifestation of allergy, and then leading to asthma and hay fever. 2️⃣ Dual Allergen Exposure Hypothesis: Research suggests that allergy-related diseases are linked to eczema via the Dual Allergen Exposure Hypothesis, which proposes that disrupted skin barrier in eczema allows for the passage of allergens to enter the body, which may trigger pathways that lead to food allergies. 3️⃣ Skin barrier genes: Skin barrier disruption in eczema is in part due to genes involving filaggrin, which is a protein essential to maintaining skin barrier resilience by promoting skin hydration. Researchers suggest that certain amino acids may promote filaggrin production. 4️⃣ Skin barrier & gut health: Skin barrier function is suggested to be linked to gut health. Researchers suggest that gut-derived short chain fatty acids (SCFAs) may promote skin barrier resilience. SCFAs are made by bacteria after they digest dietary fiber. 5️⃣ Foods for SCFAs and the bacteria that make them: Researchers suggest that edible plant diversity (eating 30+ different edible plants per week), berries, and green tea promote bacteria that produce SCFAs. 6️⃣ Topical skin barrier relief: The Cochrane Skin Group concluded that moisturizers are key to reducing number of eczema flares and reducing amount of topical eczema medications needed. Researchers also suggest that washing skin in hot water promotes more skin dryness than cool water washing. • ‼️ Disclaimer: This post does not constitute as medical advice; is not meant to diagnose, prevent, treat, or cure any conditions or disease; and is meant for educational purposes only. The information in this post does not replace or substitute the advice of your medical provider. Speak to your doctor before starting anything new. • 📚 References: 1) Baker, Robert B. “Incidence of Atopic Dermatitis and Eczema by Ethnic Group Seen Within a General Pediatric Practice.” The Permanente Journal, vol. 3, no. 1, 1999, pp. 31–32. 2) Bhimla A, Yap L, Lee M, Seals B, Aczon H, Ma GX. Addressing the Health Needs of High-Risk Filipino Americans in the Greater Philadelphia Region. J Community Health. 2017 Apr;42(2):269-277. doi: 10.1007/s10900-016-0252-0. PMID: 27639868; PMCID: PMC5337442. 3) Chen J, Shu Y, Chen Y, Ge Z, Zhang C, Cao J, Li X, Wang Y, Sun C. Evaluation of Antioxidant Capacity and Gut Microbiota Modulatory Effects of Different Kinds of Berries. Antioxidants (Basel). 2022 May 22;11(5):1020. doi: 10.3390/antiox11051020. PMID: 35624885; PMCID: PMC9137550. 4) Dunlop JH, Keet CA. Allergic diseases among Asian children in the United States. J Allergy Clin Immunol. 2019 Dec;144(6):1727-1729.e6. doi: 10.1016/j.jaci.2019.08.009. Epub 2019 Aug 23. PMID: 31449913; PMCID: PMC8456364. 5) Ghimire S, Cheong P, Sagadraca L, Chien LC, Sy FS. A Health Needs Assessment of the Filipino American Community in the Greater Las Vegas Area. Health Equity. 2018 Nov 27;2(1):334-348. doi: 10.1089/heq.2018.0042. PMID: 30506015; PMCID: PMC6263856. 6) Gibbs NK. l-Histidine Supplementation in Adults and Young Children with Atopic Dermatitis (Eczema). J Nutr. 2020 Oct 1;150(Suppl 1):2576S-2579S. doi: 10.1093/jn/nxaa200. PMID: 33000160. 7) Herrero-Fernandez M, Montero-Vilchez T, Diaz-Calvillo P, Romera-Vilchez M, Buendia-Eisman A, Arias-Santiago S. Impact of Water Exposure and Temperature Changes on Skin Barrier Function. J Clin Med. 2022 Jan 7;11(2):298. doi: 10.3390/jcm11020298. PMID: 35053992; PMCID: PMC8778033. 8) McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein PC, Dunn RR, Fahimipour AK, Gaffney J, Gilbert JA, Gogul G, Green JL, Hugenholtz P, Humphrey G, Huttenhower C, Jackson MA, Janssen S, Jeste DV, Jiang L, Kelley ST, Knights D, Kosciolek T, Ladau J, Leach J, Marotz C, Meleshko D, Melnik AV, Metcalf JL, Mohimani H, Montassier E, Navas-Molina J, Nguyen TT, Peddada S, Pevzner P, Pollard KS, Rahnavard G, Robbins-Pianka A, Sangwan N, Shorenstein J, Smarr L, Song SJ, Spector T, Swafford AD, Thackray VG, Thompson LR, Tripathi A, Vázquez-Baeza Y, Vrbanac A, Wischmeyer P, Wolfe E, Zhu Q; American Gut Consortium; Knight R. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May 15;3(3):e00031-18. doi: 10.1128/mSystems.00031-18. PMID: 29795809; PMCID: PMC5954204. 9) Nemeth V, Syed HA, Evans J. Eczema. 2024 Mar 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30855797. 10) Palmer DJ. Vitamin D and the Development of Atopic Eczema. J Clin Med. 2015 May 20;4(5):1036-50. doi: 10.3390/jcm4051036. PMID: 26239464; PMCID: PMC4470215. 11) Trompette A, Pernot J, Perdijk O, Alqahtani RAA, Domingo JS, Camacho-Muñoz D, Wong NC, Kendall AC, Wiederkehr A, Nicod LP, Nicolaou A, von Garnier C, Ubags NDJ, Marsland BJ. Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation. Mucosal Immunol. 2022 May;15(5):908-926. doi: 10.1038/s41385-022-00524-9. Epub 2022 Jun 7. PMID: 35672452; PMCID: PMC9385498. 12) van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BWM. Emollients and moisturisers for eczema. Cochrane Database Syst Rev. 2017 Feb 6;2(2):CD012119. doi: 10.1002/14651858.CD012119.pub2. PMID: 28166390; PMCID: PMC6464068. 13) Xiao X, Hu X, Yao J, Cao W, Zou Z, Wang L, Qin H, Zhong D, Li Y, Xue P, Jin R, Li Y, Shi Y, Li J. The role of short-chain fatty acids in inflammatory skin diseases. Front Microbiol. 2023 Feb 2;13:1083432. doi: 10.3389/fmicb.2022.1083432. PMID: 36817115; PMCID: PMC9932284. 14) Yuan X, Long Y, Ji Z, Gao J, Fu T, Yan M, Zhang L, Su H, Zhang W, Wen X, Pu Z, Chen H, Wang Y, Gu X, Yan B, Kaliannan K, Shao Z. Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome. Mol Nutr Food Res. 2018 Jun;62(12):e1800178. doi: 10.1002/mnfr.201800178. Epub 2018 Jun 10. PMID: 29750437; PMCID: PMC6033105. 15) Zysk W, Mesjasz A, Trzeciak M, Horvath A, Plata-Nazar K. Gastrointestinal Comorbidities Associated with Atopic Dermatitis-A Narrative Review. Int J Mol Sci. 2024 Jan 18;25(2):1194. doi: 10.3390/ijms25021194. PMID: 38256267; PMCID: PMC10815992. •