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Broad Institute of MIT and Harvard This page aims to provide an interactive forum for the public to learn more about the science, culture and life of the Broad Institute. The Eli and Edythe L.

Please note that by participating, you agree to abide by some basic guidelines (www.broadinstitute.org/node/2408) Broad Institute of Harvard and MIT was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; devel

op effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community. Founded by MIT, Harvard and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide.

24/07/2025

Join us for a science story time at the Broad Discovery Center on July 31 from 11 am - 12 pm. Sit and listen to a favorite book read by one of our scientist volunteers, followed by an arts and craft project inspired by the story. Afterwards, visitors are welcome to explore the museum and book fair. This program is designed for children of all ages and their caregivers.

https://www.broadinstitute.org/broad-discovery-center/bdc-events

One promising approach to treating infections with viruses like Ebola is to target host proteins essential to the virus....
24/07/2025

One promising approach to treating infections with viruses like Ebola is to target host proteins essential to the virus. Researchers at the Broad and the National Emerging Infectious Diseases Laboratories at Boston University used an image-based screening method, optical pooled screening, along with CRISPR perturbation to test the effects of silencing genes in millions of human cells infected with Ebola. They found multiple host proteins that, when suppressed, crippled the ability of Ebola virus to replicate, representing potential new drug targets for reducing disease severity in infected patients.

đź”—: broad.io/Ebola-News-0724

David Liu, his team, and The Jackson Laboratory researchers, in a partnership with RARE Hope, have used prime editing, a...
21/07/2025

David Liu, his team, and The Jackson Laboratory researchers, in a partnership with RARE Hope, have used prime editing, a precise and versatile form of gene editing, to correct the root cause of a rare brain disorder called alternating hemiplegia of childhood (AHC) in mice. The team used a scalable approach to develop prime editing treatments that directly repaired five different AHC mutations. Treated mice had far fewer and less severe symptoms of AHC, and survived more than twice as long as untreated mice.

It’s the first time prime editing has been used to treat a neurological disease in animals, offering hope for treating people with AHC and other genetic brain disorders.

đź”—: broad.io/Prime-AHC

Nina English Frost Hope for Annabel

We are thrilled to announce that Seth Klarman will become the next Chair of the Broad Institute Board of Directors, succ...
17/07/2025

We are thrilled to announce that Seth Klarman will become the next Chair of the Broad Institute Board of Directors, succeeding Eric Schmidt. We also welcome Aviv Regev as a new member of the Board.

broad.io/Klarman-Board

17/07/2025

Learn about your pet's behavior with Darwin's Ark and the Broad Discovery Center

02/07/2025

Book a group tour

Up to half of patients with Crohn’s disease, an inflammatory bowel disease, develop a complication called fibrosis, wher...
25/06/2025

Up to half of patients with Crohn’s disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these gut “strictures” is surgery.

Now, new spatial maps from researchers at the Broad Institute and Massachusetts General Hospital reveal the cells and genes involved in stricture formation and lay the foundation for better treatments.

đź”—: broad.io/CrohnsNews0625

Baby K.J. Muldoon is the first person to be treated with a customized gene editing therapy, created in record time just ...
24/06/2025

Baby K.J. Muldoon is the first person to be treated with a customized gene editing therapy, created in record time just for him. With his blood ammonia levels now in the normal range, K.J. is thriving. Repeating this success for the millions born each year with a rare genetic disorder, however, is no easy task, but with the right organization and support, personalized gene editing could become a scalable infrastructure. In a Q&A, we spoke with Broad core member David Liu about what made K.J.’s treatment possible, why it’s so significant, and how these on-demand treatments could one day become routine.

đź”—: broad.io/DLQA

Being a neuroscientist in a lab focused on protein trafficking in the kidney has given Giulia Monti a unique perspective...
17/06/2025

Being a neuroscientist in a lab focused on protein trafficking in the kidney has given Giulia Monti a unique perspective on Alzheimer’s disease.

“I love the idea of studying biology at its core, where the same basic principles can apply across different systems,” she said.

Learn more about a potential paradigm shift she sees in Alzheimer’s research in a new &A.

Learn more: broad.io/WISGiulia

29/05/2025

The shapes of cell nuclei can help doctors diagnose diseases ranging from cancers to blood disorders. A new technique called expansion in situ genome sequencing (ExIGS) from Ajay Labade, Zachary Chiang, Caroline Comenho, Fei Chen, Jason Buenrostro, and others is now expanding the amount of information researchers can extract from individual nuclei. ExIGS — a combination of in situ sequencing and expansion microscopy — allows scientists to sequence DNA and map its location relative to nuclear proteins at high resolution.

Applied to cells from patients with progeria, ExIGS revealed that mutated nuclear proteins may suppress the expression of certain genes.

đź”—: https://www.broadinstitute.org/node/5558751

Video caption:

Left: Stepping through a 3D image stack of lamin A/C structures in a physically expanded nucleus from an individual with progeria.

Right: Same, but with 3D genomic reads overlaid in their original spatial locations, colored by chromosome.

More than 1 million people die of antibiotic-resistant infections every year. Doctors need new ways to treat these patie...
28/05/2025

More than 1 million people die of antibiotic-resistant infections every year. Doctors need new ways to treat these patients, but none of the antibiotics discovered in the last 10 years kill bacteria through new mechanisms, and it is likely that bacteria will evolve to resist these newer treatments.

A microfluidic approach from the Broad Institute and Tufts University could help scientists discover unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria.

broad.io/CITADel-news

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