08/21/2025
PENTALGIN (5-in-1) is used to relieve pain syndrome of various origins:
• Pain in the joints, muscles, sciatica, menstrual pain, neuralgia, toothache, and headache (including headache caused by spasm of cerebral vessels).
• Pain associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, and renal colic.
• Post-traumatic and postoperative pain syndrome, which is accompanied by inflammation.
• Colds, accompanied by febrile syndrome (as a symptomatic therapy).
KEY INGREDIENTS:
• Paracetamol is a non-narcotic analgesic, has an antipyretic and analgesic effect due to the blockade of cyclooxygenase in the central nervous system and its effect on the centers of pain and thermoregulation.
• Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of cyclooxygenase, which regulates the synthesis of prostaglandins.
• Caffeine – causes dilation of blood vessels in skeletal muscles, heart, and kidneys; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the blood vessels of the brain.
• Drotaverine – has a myotropic antispasmodic effect due to inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, genitourinary, and vascular systems.
• Pheniramine is a blocker of H1-histamine receptors. It has antispasmodic and mild sedative effects, reduces the phenomena of exudation, and enhances the analgesic effect of paracetamol and naproxen.
DIRECTIONS:
The drug is taken 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets.
The duration of treatment is not more than 3 days as an antipyretic and not more than 5 days as an anesthetic.
POSSIBLE SIDE EFFECTS:
Allergic reactions: skin rash, itching, urticaria, angioedema;
From the hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia;
From the nervous system: agitation, anxiety, increased reflexes, tremor, sleep disturbances, dizziness, decreased concentration;
From the cardiovascular system: palpitations, arrhythmias, increased blood pressure;
From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, impaired liver function;
From the urinary system: impaired renal function;
CONTRAINDICATIONS:
gastrointestinal bleeding, complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, including a history of severe liver and/or renal failure, depression bone marrow hematopoiesis, condition after coronary artery bypass grafting; severe organic diseases of the cardiovascular system (including acute myocardial infarction), paroxysmal tachycardia, frequent ventricular extrasystole, severe arterial hypertension, hyperkalemia, children under 18 years of age, pregnancy and lactation.
Gastrointestinal bleeding, complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, including a history of severe liver and/or renal failure, depression bone marrow hematopoiesis, condition after coronary artery bypass grafting; severe organic diseases of the cardiovascular system (including acute myocardial infarction), paroxysmal tachycardia, frequent ventricular extrasystole, severe arterial hypertension, hyperkalemia, children under 18 years of age, pregnancy and lactation.
