Kat Toups, MD - Functional Medicine Psychiatry & Dementia

04/15/2026

Judy Benjamin is one of my heroes, and it's been my honor and pleasure to work with her as a board member on the Alzheimer’s Survivors Foundation that she started.

She walked across America from San Diego to the East Coast of Florida to do press interviews along the way with the goal of promoting ASAP and highlighting that Alzheimer’s survivors exist. And she did this at age 81!

If you support the concept and the mission of reversing Alzheimer’s, please consider joining our organization. There is no cost. we're collecting stories of Alzheimer’s survivors, so please feel free to share your own story if you are so inclined.

Https://alzheimerssurvivors.org/

04/11/2026

ALZHEIMER'S SUMMIT - starts today – Saturday 4/11

I'm so sorry about the short notice, but the free Alzheimer’s Summit starts today.

I have a talk on day 2 with Dale Bredesen about our latest precision medicine study - over 90% of our patients had improvement, and many had reversal of their cognitive decline or dementia.

Looks like they have a lot of interesting speakers and topics. Please feel free to share with anyone who might be interested. 🌻

02/24/2026

Check this out! Our 2022 Precision Medicine Alzheimer’s Paper is still the most widely read paper in the Journal of Alzheimer’s Disease in the last six months.

It's basically stayed in the most widely read articles in JAD since we first published. 🎉

Stay tuned for the publication of our follow up RCT trial. You can find it on pre-print, and we're almost finished the revisions for submission for peer review at JAD.

02/13/2026

Excerpts from a talk I gave at IMMH 2025 (Integrative Medicine for Mental Health) on the clinical trials and work I do with reversing MCI and early dementia.

IMMH 2026 will be in San Diego in early October, and I'm helping to organize a 4-hour workshop there on dementia and neurodegenerative disorders.

IMMH - Integrative Medicine for Mental Health
Kiki Newman Smulders
Yousef Elyaman

01/08/2026

ZOOM BROADCAST on EVANTHEA DEMENTIA STUDY RESULTS

Friday 1/9 at 2 PM PST

Doctors Dale Bredesen and Ann Hathaway and I will be doing a live broadcast to discuss our groundbreaking Precision Medicine dementia study results.

The recording will be posted afterward on the Apollo Health page and website. I can repost that when it happens.

it would be great if you could share this with people who might be interested in learning more about the study and the exciting results we got.

We want more people to know that we can reverse dementia and not just slow it down like the other medications and treatment modalities thus far.

Every single patient in the active treatment arm in the study at my site got better, and all but one were testing completely normal by the end of the study.

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Here's the link to the recording:

https://youtu.be/n62LpnSYaeo

The Evanthea randomized clinical trial has concluded, and the cognitive improvements exceed anything previously published. Come hear the discussion about what is next, and what features led to such positive results, as Dr. Ann Hathaway and Dr. Kat Toups join Dr. Bredesen on Friday, January 9th at 2....

01/03/2026

This is fascinating! See my comments below.

A published medical case report described an 82-year-old man with Alzheimer’s disease who had experienced a steady cognitive decline for five years. At baseline, his Mini-Mental State Examination (MMSE) score was 20/30, consistent with mild dementia. His symptoms included memory loss, confusion, low mood, and reduced social engagement. He was taking standard Alzheimer’s medications (donepezil and memantine), which had not stopped disease progression. He later underwent a single f***l microbiota transplant (FMT) using stool from his cognitively healthy wife — the procedure was performed to treat recurrent Clostridioides difficile infection, not dementia.

Two months after the FMT, clinicians documented a marked cognitive change: his MMSE score increased to 26, placing him back in the normal range. By six months, his score further improved to 29, with sustained gains in memory, mood, and social interaction. Notably, he was again able to remember his daughter’s birthday, engage more actively in conversations, and show improved affect. No Alzheimer’s medications were changed during this period, leading the authors to suggest that altering the gut microbiome may have directly influenced brain function via the gut–brain axis, while emphasizing this was a single human case report, not a proven treatment.

PMID: 32600151

01/01/2026

Happy New Year, everyone! 🎉

I'm excited to announce that we got the PrePrint publication out on our latest randomized Precision Medicine Dementia study yesterday.

You can get an idea of the groundbreaking results we got by looking at the graphs in the paper, particularly the final Forest Plot graph (shown below). That one shows the magnitude of the effect size of our study compared to a couple of the main anti-amyloid medications (like 7 times the effect size as Lecanemab!), as well as several studies on lifestyle interventions.

As many of you know, this has been a labor of love and my passion for a number of years now, and I've served as the Principal Investigator on both of our multimodal Precision Medicine dementia trials. I'm so excited that the results of this randomized trial replicate our first proof concept trial, and are even better than the first one!

My sincere hope is that these findings will motivate and empower more people to work on changing the trajectory of their cognitive decline. And even more importantly, for people to believe that these are variables that we can control, and they can address these proactively to prevent the cognitive decline in the first place.

https://www.preprints.org/manuscript/202512.2694



12/25/2025

I absolutely agree with this – for most people, Dementia is a process that has been brewing over years and probably decades.

An ounce of Prevention…

We're getting better and better at reversing dementia if we can catch things before it's too late.

(Stay tuned for the pre-print publication of our latest Precision Medicine multi-modal clinical trial by the end of 2025. Our results were even better than our proof of concept trial.)

But everything we learn about Reversing Dementia should be considered for preventing it in the first place.

11/11/2025

The Healing Dementia Summit starts Wednesday 11/12 and runs for 12 days.

My talk is on Day 3 (Friday 11/14) and we covered a lot of ground in this interview:

Mold, Infections, and Hormone Loss: The Hidden Triggers of Dementia Most Doctors Overlook

But don't miss Dale Bredesen and Judy Benjamin on Day 1. Judy Benjamin was Dale Bredesen's patient zero (the first patient using his methodology to reverse dementia). To celebrate reversing her dementia 13 years ago, she founded the Alzheimer's Survivors Foundation (ASF), and walked across America from San Diego to Saint Augustine, Florida to raise awareness that Alzheimer's survivors exist!

This would be a feat at any age, but it's almost unthinkable that Judy has done this at age 81! Judy finishes her epic walk on Saturday 11/15.

Judy's interview is going to feature lots of fantastic drone footage of her walk!

There are many other excellent topics being covered at this summit, including things like dental infections, EMFs, Long Covid and the brain, and photobiomodukation (PBM).



Beyond the No-Cure Narrative—21 Experts Share Complementary Approaches to Reverse Cognitive Decline

10/27/2025

I'm honored to have been a consultant and the research director for this groundbreaking program, and beyond thrilled with the excellent results.

Our mission is to help people with chronic depression get well, and not just manage their symptoms with medication and psychotherapy.

09/28/2025

4 free hours of CME on Metabolic Psychiatry.

09/06/2025

Reversing Cognitive Decline and Dementia with Precision Medicine

I finally got around to uploading a talk with slides to my YouTube channel that I gave at The Forum for Integrative Medicine's annual 2025 conference.

It's fast and furious with so much to cover in only an hour, but it's a pretty detailed overview for people that are interested in this topic.

NOTE: This is shared with permission of The Forum for Integrative Medicine. They kindly allowed me to share this for educational purposes, so it's ok if you want to share it.

Dementia is not an inevitable one-way decline. In this talk from the Forum for Integrative Medicine Annual Conference (April 4, 2025), Dr. Kat Toups presents...