The New England Journal of Medicine

The New England Journal of Medicine The New England Journal of Medicine (NEJM.org) is the world's leading medical journal and website.

04/19/2026

A 74-year-old man presented to the emergency department with a 3-day history of a painful laceration on his right leg that he had sustained while jumping into waters off the Gulf Coast of Florida. Two days after the injury to his leg, skin changes had appeared on his right arm. Physical examination is shown of the right lower leg and right forearm. He had no known history of chronic liver disease or an immunocompromising condition. What is the most likely diagnosis? https://nej.md/IC04162026

Is coffee helping or harming our patientsโ€™ hearts? In the latest episode of the Beyond Journal Club podcast from CORE IM...
04/18/2026

Is coffee helping or harming our patientsโ€™ hearts? In the latest episode of the Beyond Journal Club podcast from CORE IM and NEJM Group, the hosts unpack the CRAVE trial and use it as a lens to answer a bigger question: How should clinicians interpret nutrition research, especially when it feels inconsistent or hard to trust?

04/17/2026

A new Double Take video reviews the differential diagnosis for a woman with night sweats and unintentional weight loss and how it evolves as new clinical findings are presented.

A 16-year-old girl presented with 1 month of ankle pain and 11 days of fever. Radiographs showed an ill-defined, radiolu...
04/17/2026

A 16-year-old girl presented with 1 month of ankle pain and 11 days of fever. Radiographs showed an ill-defined, radiolucent distal tibial lesion; on MRI, the lesion was hypointense and surrounded by a hyperintense sclerotic rim.

04/16/2026

Induction medication for emergency intubation โ€” does the choice matter? NEJM Editorial Fellow Katerina Lin, MD, explains a randomized trial to determine the effects of ketamine vs. etomidate for induction of anesthesia during emergency tracheal intubation.

Combined oral contraceptives and hormone-replacement therapy increase the risk of venous thromboembolism, although the a...
04/16/2026

Combined oral contraceptives and hormone-replacement therapy increase the risk of venous thromboembolism, although the absolute risk is low. Transdermal estradiol and micronized progesterone carry lower risk.

04/15/2026

NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD, explains a trial recently published in NEJM that compared catheter-directed thrombolysis to anticoagulation alone for acute, intermediate-risk pulmonary embolism.

A study in a mouse model of ๐˜”๐˜ ๐˜Š๐˜•-amplified neuroblastoma implicates polyamine levels in affecting the makeup of the prot...
04/15/2026

A study in a mouse model of ๐˜”๐˜ ๐˜Š๐˜•-amplified neuroblastoma implicates polyamine levels in affecting the makeup of the proteome and biologic characteristics of the tumor.

04/14/2026

This video in our partnership with Dr. Glaucomflecken explains a clinical trial evaluating the clinical efficacy of tecovirimat against human clade II mpox.

A 68-year-old man who had undergone intubation 25 days earlier had difficulty swallowing after extubation. A swallowing ...
04/14/2026

A 68-year-old man who had undergone intubation 25 days earlier had difficulty swallowing after extubation. A swallowing study showed fluid penetrating into the trachea without triggering a cough reflex (shown in a video).

An innovative care delivery model at Mayo Clinic integrates virtual oversight, remote patient monitoring, mobile health ...
04/13/2026

An innovative care delivery model at Mayo Clinic integrates virtual oversight, remote patient monitoring, mobile health services, and a unified software platform connected to the electronic medical record that could serve as a scalable blueprint for expanding access to cancer treatment across diverse populations and geographies.

04/13/2026

How is cumulative medical imaging in childhood associated with cancer risk? NEJM Editorial Fellow Katerina Lin, MD, summarizes a recent retrospective cohort study involving 3 million children.

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Over 200 Years of Medical Publishing

The New England Journal of Medicine (NEJM) is the worldโ€™s leading medical journal and website. Published continuously for over 200 years, NEJM delivers high-quality, peer-reviewed research and interactive clinical content to physicians, educators, and the global medical community.

Our mission is to bring physicians the best research and information at the intersection of biomedical science and clinical practice and to present this information in understandable and clinically useful formats that inform health care delivery and improve patient outcomes.

To these ends, the NEJM editorial team employs rigorous:


  • Editorial, peer, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance.