The New England Journal of Medicine

The New England Journal of Medicine The New England Journal of Medicine (NEJM.org) is the world's leading medical journal and website.

03/13/2026

A video shows the administration of DB-OTO, an adeno-associated virus 1 gene therapy that delivers OTOF cDNA to treat congenital deafness.

03/12/2026

For a patient with hypertension, would you recommend a systolic blood-pressure target of less than 120 mm Hg and or a target of less than 140 mm Hg?

A woman presented with a 1-year history of a crawling sensation on her chin that caused her to scratch the area. An irre...
03/11/2026

A woman presented with a 1-year history of a crawling sensation on her chin that caused her to scratch the area. An irregular ulcer was present on the right side of her chin, with reduced sensation around the mouth, lip, and chin.

A 47-year-old man was brought to the ED by EMS after being found dyspneic in his car. He reported having been drinking f...
03/10/2026

A 47-year-old man was brought to the ED by EMS after being found dyspneic in his car. He reported having been drinking for 6 hours before presentation. He noted a sensation of tongue swelling and difficulty breathing.

A woman with asthma and obstructive sleep apnea presented with a 1-month history of worsening dyspnea and dry cough. CT ...
03/09/2026

A woman with asthma and obstructive sleep apnea presented with a 1-month history of worsening dyspnea and dry cough. CT of the chest showed anterior bowing of the posterior wall of the intrathoracic trachea during expiration.

03/09/2026

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen.

𝐀π₯𝐭𝐞𝐫𝐧𝐚𝐭𝐒𝐯𝐞 𝐬𝐩π₯𝐒𝐜𝐒𝐧𝐠 is the use of different exons in the formation of messenger RNA from initially identical transcript...
03/08/2026

𝐀π₯𝐭𝐞𝐫𝐧𝐚𝐭𝐒𝐯𝐞 𝐬𝐩π₯𝐒𝐜𝐒𝐧𝐠 is the use of different exons in the formation of messenger RNA from initially identical transcripts, which can result in the generation of related proteins from one gene, often in a manner specific to a type of tissue or a developmental stage.

A new review summarizes advances in radiotherapy that reduce injury to normal tissue, including improvements in the prec...
03/07/2026

A new review summarizes advances in radiotherapy that reduce injury to normal tissue, including improvements in the precision of imaging and delivery, and outlines strategies to prevent and manage treatment-related side effects.

03/07/2026

A 74-year-old man presented to the hospital for the third time in three weeks with recurrent fever, muscle aches, and vomiting. In the prior two hospitalizations, symptoms had self-resolved and broad work-up was unremarkable. He had traveled to Yosemite National Park one week prior to symptom onset. Physical examination was notable for rigors and diaphoresis. Peripheral blood smears are shown. What is the most likely diagnosis? https://nej.md/IC03052026

03/06/2026

Emily Hill, DO, who recently finished her family medicine residency, discusses a case that turned out to be one of her most gratifying she had as a resident.

Gemma L. Carvill, PhD, and Heather C. Mefford, MD, PhD, describe the scientific foundations of a study of zorevunersen, ...
03/05/2026

Gemma L. Carvill, PhD, and Heather C. Mefford, MD, PhD, describe the scientific foundations of a study of zorevunersen, an antisense oligonucleotide, for the treatment of a severe epilepsy syndrome.

Patients with end-stage kidney disease (ESKD) have a high rate of hospitalizations related to fluid overload and infecti...
03/05/2026

Patients with end-stage kidney disease (ESKD) have a high rate of hospitalizations related to fluid overload and infections. Artificial intelligence (AI)–driven models may improve patient care by predicting the risk of hospitalization.

Chaudhuri and colleagues conducted a retrospective, observational matched cohort study of adult patients with ESKD who were receiving value-based hemodialysis at integrated kidney care clinics across the United States in 2023. The results are now published in NEJM Catalyst Innovations in Care Delivery.

Two AI-powered machine learning models calculated risk scores (range: 0–1) and the models identified patients with a risk score of 0.64 or above who were at risk for hospitalization within 7 days in relation to infections or fluid status abnormalities. To prevent avoidable hospitalizations, case reviews and interventions were conducted for the patients identified by the models. The AI models generated scores for all patients, but only high-risk scores triggered case review and possible intervention.

The authors linked electronic medical records and Medicare claims data and conducted multivariate logistic regression analyses to examine the impact of AI-driven interventions on the odds of all-cause hospitalization in patients with ESKD. A total of 10,294 patients representing 83,928 risk scores were included in the analysis.

AI-driven interventions were associated with a reduction in the odds of hospitalization among patients with ESKD receiving managed kidney care. These findings underscore AI’s potential to assist health care providers with targeted risk interventions for patients with ESKD.

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Over 200 Years of Medical Publishing

The New England Journal of Medicine (NEJM) is the world’s leading medical journal and website. Published continuously for over 200 years, NEJM delivers high-quality, peer-reviewed research and interactive clinical content to physicians, educators, and the global medical community.

Our mission is to bring physicians the best research and information at the intersection of biomedical science and clinical practice and to present this information in understandable and clinically useful formats that inform health care delivery and improve patient outcomes.

To these ends, the NEJM editorial team employs rigorous:


  • Editorial, peer, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance.