The New England Journal of Medicine

The New England Journal of Medicine The New England Journal of Medicine (NEJM.org) is the world's leading medical journal and website.
(7970)

12/13/2025

A 72-year-old woman presented to the dermatology clinic with a 3.5-month history of an enlarging, painless lump on her left cheek. A punch biopsy showed dermal infiltration by small, round, blue cells arranged in nests, with scant cytoplasm and frequent mitoses. Immunohistochemical testing for perinuclear CK20 and synaptophysin was positive. What is the most likely diagnosis? https://nej.md/IC12112025

Case Record of the Massachusetts General Hospital: A 5-year-old boy was admitted to the hospital because of fever and ra...
12/12/2025

Case Record of the Massachusetts General Hospital: A 5-year-old boy was admitted to the hospital because of fever and rash.

The patient had been well until 3 days before the current presentation, when his mother noticed that he was not eating and drinking as much as usual. Later that day, the oral temperature measured at home was 39.2°C. The patient’s mother gave him acetaminophen, and his fever abated.

Two days before the current presentation, an itchy rash appeared on the dorsal surface of both feet and spread toward the shins. The patient’s mother took him to the emergency department of another hospital.

On evaluation, the temporal temperature was 36.7°C. The patient appeared well. Diffuse blanching macules and papules were present on the legs, and a few scattered papules were seen on the buttocks and lower back. The rash was considered to be consistent with exposure to poison ivy. Treatment with ibuprofen was administered, a course of oral prednisone was prescribed, and the patient was discharged home. The patient’s mother was instructed to give him antihistamines as needed for itching.

In the latest episode of the Not Otherwise Specified podcast, host Lisa Rosenbaum, MD, and her guests dissect the common...
12/12/2025

In the latest episode of the Not Otherwise Specified podcast, host Lisa Rosenbaum, MD, and her guests dissect the common notion that the key to improving the primary care system is simply increasing reimbursement.

A new review summarizes the diagnosis and treatment of complex regional pain syndrome, a rare limb-pain disorder. Early ...
12/11/2025

A new review summarizes the diagnosis and treatment of complex regional pain syndrome, a rare limb-pain disorder. Early rehabilitation and multidisciplinary care are key; most patients improve within 18 months.

12/10/2025

In a Review Article from earlier this year, the authors consider available information about the benefits and risks of testosterone treatment in middle-aged and older men with moderate degrees of hypogonadism.

A 66-year-old man presented with 2 weeks of shortness of breath and cough, 5 days of left flank pain, and 2 days of a ra...
12/09/2025

A 66-year-old man presented with 2 weeks of shortness of breath and cough, 5 days of left flank pain, and 2 days of a rapidly expanding mass on his left side.

12/09/2025

In the landmark CREST-2 study, stenting was associated with fewer nondisabling strokes at 4 years. Read the full summary and comment from Dr. Allan Brett: https://jwat.ch/3Mref1D

Stay informed with key insights you can trust. Visit the new NEJM Clinician: https://clinician.nejm.org

Adults with late-onset Pompe disease typically present with progressive myopathy and respiratory symptoms, although init...
12/09/2025

Adults with late-onset Pompe disease typically present with progressive myopathy and respiratory symptoms, although initial manifestations are extremely varied. Some patients present with respiratory failure without apparent neurologic or muscular deficits. Other manifestations include vascular malformations, oral–gastrointestinal abnormalities (e.g., dysphagia, gastroesophageal reflux, constipation, and dysmotility), cardiovascular abnormalities (e.g., arrhythmias, conduction abnormalities, and cardiomyopathy), and cognitive and emotional disturbances (e.g., depression and anxiety).

Figure 2 from the article illustrates the genetic mechanisms and clinical manifestations of late-onset Pompe disease.

Shown is a nonexhaustive representation of multisystem clinical manifestations of late-onset Pompe disease. The severity and range of clinical manifestations vary among persons and are influenced by the functional consequences of pathogenic variants in GAA, the gene that encodes acid α-glucosidase.

In a new editorial, the editors announce the launch of NEJM Clinician, a new digital publication that delivers timely cl...
12/08/2025

In a new editorial, the editors announce the launch of NEJM Clinician, a new digital publication that delivers timely clinical insight and practical guidance to keep you informed — preserving the NEJM Journal Watch spirit of trusted curation and commentary while expanding its reach and depth.

For a preclinical grading system in a medical school, should you support the continuation of the five-tier grading syste...
12/08/2025

For a preclinical grading system in a medical school, should you support the continuation of the five-tier grading system (A, B, C, D, F) or recommend implementation of a pass/fail system?

12/07/2025

A 26-year-old woman presented with pain in her left elbow after falling on an outstretched hand while ice-skating. Physical examination revealed left lateral elbow swelling and tenderness to palpation, a valgus deformity, and limited range of motion. What findings are present on the imaging? https://nej.md/IC12042025

12/06/2025

In a pragmatic trial conducted in general medical wards with limited diagnostic and therapeutic resources in Kenya, glucocorticoids reduced mortality in patients with community-acquired pneumonia.

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Over 200 Years of Medical Publishing

The New England Journal of Medicine (NEJM) is the world’s leading medical journal and website. Published continuously for over 200 years, NEJM delivers high-quality, peer-reviewed research and interactive clinical content to physicians, educators, and the global medical community.

Our mission is to bring physicians the best research and information at the intersection of biomedical science and clinical practice and to present this information in understandable and clinically useful formats that inform health care delivery and improve patient outcomes.

To these ends, the NEJM editorial team employs rigorous:


  • Editorial, peer, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance.