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Monday 8:30am - 5:30pm Tuesday 8:30am - 5:30pm Wednesday 8:30am - 5:30pm Thursday 8:30am - 5:30pm Friday 8:30am - 5:30pm

Patient-Centered Outcomes Research Institute - PCORI

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Patient-Centered Outcomes Research Institute - PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

04/08/2026

PCORI is interested in submissions that address the following Special Areas of Emphasis within the upcoming BPS PFA:

◼️ Addressing Obesity
◼️ Diabetes Prevention, Care and Treatment
◼️ Management of Urogynecological and Pelvic Pain
◼️ Pain Management for Individuals Living With Sickle Cell Disease

Learn more in tomorrow's Town Hall: https://pcori.me/40wUeuy

04/07/2026

The PLACER PFA seeks to fund high-impact patient-centered CER projects that will address critical decisions faced by patients, families, caregivers, clinicians, and the health and healthcare community and for which there is insufficient evidence.

Learn the details of this funding announcement in tomorrow's Town Hall happening at 11:30 am (ET). https://pcori.me/471Xu4I

04/06/2026

PCORI is interested in submissions that address the following Special Areas of Emphasis within the upcoming Addressing Sensory Health Needs Across the Lifespan PFA:

◻️ Increasing screening and early detection for people with sensory health conditions
◻️ Improving treatment and care coordination for people with sensory health conditions
◻️ Enhancing support services to improve mental health and address stigma experienced by individuals with sensory health conditions, their families and their care partners

Learn more in a Town Hall happening tomorrow at noon (ET): https://pcori.me/4urg9ky

04/03/2026

The Improving Methods PFA seeks to fund studies addressing important methodological gaps in patient-centered CER.

🆕 New Program Priority: Methods To Support the Use of Patient-Centered Measurement in Patient-Centered CER

Learn more in Town Hall happening April 6 at Noon (ET): https://pcori.me/4lqPMab

04/02/2026

The latest edition of PCORI's Emerging Health Care Innovation Brief highlights the first FDA-approved therapy to treat arginase 1 deficiency.

Other topics include:
◽ Pariglasgene brecaparvovec (DTX401), an investigational gene therapy designed to treat glycogen storage disease Type 1a
◽ Tinlarebant, an orally administered small-molecule drug intended to treat Stargardt disease 1

Learn more: https://pcori.me/4sKyY0H

04/01/2026

PCORI is now accepting Letters of Intent for the following PCORI Funding Announcements:

◾ Addressing Sensory Health Needs Across the Lifespan
◾ Phased Large Awards for Comparative Effectiveness Research
◾ Broad Pragmatic Studies
◾ Advancing the Science of Engagement in Research
◾ Improving Methods for Conducting Patient-Centered CER

Learn more about each PFA in upcoming Town Halls: https://pcori.me/3NSy1V6

03/31/2026

A PCORI-funded patient-centered CER study compared two treatments that could serve as effective alternatives when traditional office-based dental care is costly or too far:

1️⃣ Biannual silver diamine fluoride, a noninvasive treatment designed to slow or stop tooth decay
2️⃣ Atraumatic restorative treatment — applying a filling without drilling — coupled with biannual fluoride varnish

Explore the study: https://pcori.me/4dlux7L

03/30/2026

PCORI is seeking public input on draft research questions for an upcoming systematic review: Removal of Myomas in Asymptomatic Patients To Improve Fertility or Reduce Miscarriage Rate.

Your input on the draft key questions will help define the scope of this review and help ensure it addresses the issues related to this important topic.

Please submit your feedback by April 14 at 5 pm (ET) https://pcori.me/4rIN2GB

03/27/2026

Harnessing Patient-Centered CER To Improve Cardiovascular Health

Learn how PCORI-funded CER is helping address cardiovascular health through studies examining the effectiveness of aspirin for treating heart disease symptoms and the role of emergency services in diagnosing and treating strokes. https://pcori.me/4uXMwHW

03/26/2026

The final report for the PCORI-commissioned systematic review on Medical Care for Adults With Down Syndrome is now available.

This review examines the evidence on screening, diagnosis and treatment of co-occurring health conditions for individuals with Down syndrome. Read more: https://pcori.me/47cLjmj

03/25/2026

Thank you to the Center for Innovation & Value Research for having PCORI Executive Director Nakela Cook, MD, MPH, speak at the Methods Summit today and discuss how PCORI and IVI are key voices in the space of patient-centered value and can make a real difference working together.

Address

1333 New Hampshire Avenue Suite 1200
Washington D.C., DC
20036

Opening Hours

Monday	8:30am - 5:30pm
Tuesday	8:30am - 5:30pm
Wednesday	8:30am - 5:30pm
Thursday	8:30am - 5:30pm
Friday	8:30am - 5:30pm

Website

http://www.pcori.org/

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