JACC Journals

03/29/2026

In this multisystem cluster randomized trial, automated electronic clinician notification alerts improved timely guideline-directed evaluation and valve intervention for clinically significant aortic stenosis and mitral regurgitation. These findings suggest that electronic health record-integrated clinical decision support may represent a scalable strategy to reduce undertreatment and improve access to specialized valve care.

Get the details in : https://bit.ly/4ccYEND

03/29/2026

In what is believed to be the first randomized placebo-controlled trial of its kind, patients with a chronic total blockage of a coronary artery who received a nonsurgical procedure to reopen the artery showed statistically significant reductions in chest pain and improvements in quality of life compared with patients who received a placebo procedure. The research was presented at .

Get the details in : https://bit.ly/4tfFPza

03/29/2026

Late-breaking KARDINAL trial explores efficacy of tonlamarsen in patients with uncontrolled hypertension. Read more in : bit.ly/4uT83l3

03/28/2026

GPS-CAD is the largest global study of race, ethnicity, and environment in atherosclerotic coronary artery disease, spanning 6 continents. It is the first to examine how country and race/ethnicity shape atherosclerosis patterns vs traditional risk factors, informing locally tailored strategies to address this growing burden. https://bit.ly/4uT0aMp

03/28/2026

Combination of a TV-mAFP plus delayed did not reduce infarct size in patients with anterior without cardiogenic shock compared with PCI alone, according to an LBCT.

Get the details: https://bit.ly/4bEo9aD

03/27/2026

African countries are markedly underrepresented in RCTs in leading medical & CV journals. Expanding trial participation, investing in local research capacity, & promoting equitable leadership are key to more relevant, valid evidence. https://bit.ly/47bI7GW

03/26/2026

New 2026 ACC scientific statement reviews gene editing therapy in , covering the science, early targets (monogenic diseases like hypercholesterolemia & amyloidosis), and key ethical and cost challenges. Clinicians play a critical role in guiding safe, equitable use.

Get the details: https://bit.ly/4rYSW6W

AbstractIt is increasingly recognized that many cardiovascular diseases have a genetic basis. Advancements in genome sequencing have allowed for dramatically higher rates of genetic testing with im...

03/26/2026

Outpatient management of isolated left-to-right shunt lesions in pediatric patients with congenital heart disease is the focus of a new 2026 ACC Concise Clinical Guidance report.

Published in , the report aims to provide clinicians with a decision support framework for managing common left-to-right shunt lesions, including atrial septal defect, ventricular septal defect, patent ductus arteriosus, and atrioventricular septal defect, in the current absence of evidence-based clinical practice guidelines. Get the details: https://bit.ly/4lRUFcL

03/25/2026

🚨 Save your spot! 🚨

Join Editors-in-Chief and colleagues from across the for a reception at .

📅 March 29 | 5:30-7 p.m. CT
📍 Saint Charles Ballroom | Hilton Riverside

RSVP 👉 https://bit.ly/40SwYXZ

03/25/2026

A new multisociety Expert Consensus Systems of Care document provides operator and institutional recommendations and requirements for tricuspid interventions. Published in , the document provides guidance on implementing and maintaining a transcatheter tricuspid valve intervention program in a rapidly evolving field.

Get the details: https://bit.ly/4rUYP4T

03/24/2026

Early CRP changes during ICI therapy are associated with an increased risk of , suggesting a potential association between ICI-induced inflammation and hypercoagulability. CRP trajectories may serve as a biomarker for ICI-associated VTE.

Learn more in : https://bit.ly/4c3ZzQp

03/24/2026

After implementation of the Inflation Reduction Act's (IRA's) 2024 prescription drug provisions, cost-related medication nonadherence significantly decreased among Medicare beneficiaries with cardiovascular risk factors and conditions that were newly eligible for full low-income subsidies.

These findings indicate that the IRA’s prescription drug reforms may improve medication access and adherence among Medicare beneficiaries, with important implications for cardiovascular health in the US. https://bit.ly/4uJhRxH