Canine T-Cell Project

11/21/2025

📣Hemangiosarcoma is a rapidly growing, highly invasive variety of cancer that occurs almost exclusively in dogs, and only rarely in cats, horses, mice, or humans. It is a sarcoma arising from the lining of blood vessels; that is, blood-filled channels and spaces are commonly observed microscopically.

Abstract Objective To define the histopathologic diagnoses and clinical stage from a prospectively enrolled cohort of dogs with spontaneous hemoperitoneum (SH) of splenic origin undergoing splenectomy. Methods This post hoc analysis of prospective data evaluated canine patients presenting with SH en...

11/20/2025

What is The Nu.Q® Vet Cancer Test?⁠ 🩸💉 ⁠
⁠
It’s a cancer screening blood test that measures nucleosomes, pieces of DNA released from cancer cells into the bloodstream. (Nucleosome levels are low in healthy dogs and are elevated in dogs with certain cancers.)⁠
⁠
It helps your veterinarian detect up to:⁠
⁠
76% of systemic cancers⁠
77% of lymphomas ⁠
82% of hemangiosarcomas ⁠
54% histiocytic sarcomas⁠ ⁠
⁠


https://www.idexx.com/en/veterinary/reference-laboratories/nu-q-cancer/

11/20/2025

🐾Dogs are at risk of getting many types of cancer. They can even get many of the same types of cancer humans can get – including brain cancer. This is understandably a major concern for pet owners. You love your pup and want to know how to protect him or her. Thankfully, there are numerous treatment options available today.🐾

The most common form of brain cancer in dogs is a meningioma or a glioma. Older pets (five or more years old) have a higher risk of getting cancer and both sexes are equally vulnerable.

Signs & Symptoms of Brain Cancer in Dogs

If your dog displays these signs or symptoms of brain cancer, have him or her examined by your primary care veterinarian as soon as possible.

Seizures – This is the most common initial sign of a brain tumor. Symptoms can include collapsing, jerking, stiffening, twitching, loss of consciousness, drooling, chomping, tongue chewing, or foaming at the mouth. Dogs can fall to the side and make paddling motions with their legs. Call your veterinarian as soon as possible if your dog begins to have seizures
Abnormal Behavior – The brain is responsible for many functions, including emotions and behavior. Your dog is showing signs of increased aggression, loss of learned behavior, depression/dullness, or lethargy
Vision Loss – Your dog has trouble seeing out of one or both eyes, pupils are dilated or movement seems uncoordinated
Food and Water Intake Changes – Your dog is displaying signs of increased or decreased hunger or thirst
Neck/Head Pain – Your dog has started to tilt their head or is displaying signs of pain or sensitivity in the neck
Restless – Your dog is constantly pacing or circling to one side
Unsteady – Loss of balance is another key symptom. Your dog may stagger while walking or standing up/down
Nausea – Your dog begins to vomit due to an unknown cause
Other Signs of Cancer – While the above are some of the common signs of a brain tumor, there are other signs of cancer that don’t include the head or neck. For example, weight loss, weight gain, a persistent cough, and wounds that won’t heal are also signs of cancer.

☎️ : 833.467.2836

https://petcureoncology.com/brain-cancer-in-dogs/

11/20/2025

From Dr Sue Cancer Vet. Another great write-up!

https://www.facebook.com/share/r/1788Y3QUTi/?mibextid=wwXIfr

11/19/2025

Need from Purdue University🗞️ 🚨🩼

Canine T-cell Lymphoma Trial

Biodynamic Testing of Chemotherapy Sensitivity in Dogs Receiving Gemcitabine for Cutaneous T-cell Lymphoma
Principal Investigator
Dr. Michael Childress, Professor of Comparative Oncology

Background
Epitheliotropic cutaneous T-cell lymphoma (ETCL) in dogs is a skin cancer for which few effective therapies exist. The chemotherapy drug gemcitabine is commonly used to treat humans with this cancer. Although gemcitabine has been shown to be well-tolerated in dogs, its use as a treatment for dogs with ETCL has not been described.

https://vet.purdue.edu/wcorc/clinical-trials/canine-t-cell-lymphoma.php

10/15/2025

Scout out hemangiosarcoma" refers to the Scout Out Canine Hemangiosarcoma (SOCH) study, a clinical trial for dogs with this aggressive cancer.

The study's name is a play on the idea of the immune system being trained to "scout out" and destroy cancer cells. It tests a new therapeutic vaccine in combination with standard surgery and chemotherapy to improve outcomes for affected dogs.

What the study involves

Goal: To determine if a novel anti-cancer vaccine can improve the survival rates for dogs with splenic hemangiosarcoma.

Treatment: All participating dogs receive standard treatment, which includes surgical removal of the spleen and chemotherapy.

Vaccine component: Dogs are then randomly assigned to one of two groups:

One group receives the investigational vaccine in addition to the standard treatment.
The other group receives a placebo vaccine alongside the standard treatment.

Vaccine mechanism: The investigational vaccine is designed to stimulate the dog's immune system to recognize and destroy remaining cancer cells by targeting specific markers on the tumor cells.

Eligibility and locations

Eligibility: Dogs must meet specific criteria, including a biopsy-confirmed diagnosis of Stage I or II splenic hemangiosarcoma and having undergone a splenectomy within the past three weeks.

Locations: The study is taking place at several veterinary institutions, including the University of Wisconsin, Colorado State University, and the University of California-Davis.

10/15/2025

❤️🐾❤️Dr. Renée Alsarraf, Senior Veterinarian, Specialist in Oncology The Schwarzman Animal Medical Center , New York City, speaks about navigating through a cancer diagnosis. Great presentation!🐾♥️🐾

https://youtu.be/EAkR-ULrCeg?si=YXjs2YJmgoJBDAA

🚨Over a century ago, the Schwarzman Animal Medical Center was founded on the principle of providing companion animals with humane, quality care and treatment. Abiding by this mission and their commitment to serve the community, AMC has established financial assistance programs for eligible pet owners who cannot afford veterinary care and animal-related charities and rescue organizations.

For information please reach out to:

https://www.amcny.org/financial-assistance/?gad_source=1&gad_campaignid=23055225350&gclid=EAIaIQobChMIoPfvxuqmkAMVdmtHAR278DQsEAAYBCAAEgISo_D_BwE

10/13/2025

“Every dog parent facing a cancer diagnosis has access to the support, resources, and care they need.

United by love for dogs, we stand with Washington state families facing canine cancer- offering hope, guidance, and a caring community so every journey is met with dignity, and every dog receives the care they deserve.”

Please take a peek and discover Toby’s Hope for Canine Cancer Care heartwarming mission and their wonderful programs.🐾❤️🐾

https://tobyshope.org/tails-of-resilience-a-new-support-group-for-pet-parents-with-sick-pets-launches-in-seattle/

10/13/2025

📣📣

CAR T CELL IMMUNOTHERAPY FOR TREATMENT OF METASTATIC OSTEOSARCOMA IN DOGS 📣

PATIENT DISEASE:
Canine Osteosarcoma with Metastasis to the Lungs

STUDY NAME:
CAR T cell Immunotherapy for Treatment of Metastatic Osteosarcoma in Dogs

PURPOSE OF THE STUDY:
* To determine the safety and effectiveness of canine CAR T cells in dogs with metastatic OSA

PRIMARY ELIGIBILITY CRITERIA:
* Dogs with a confirmed diagnosis of osteosarcoma via surgery to remove their primary tumor with measurable metastatic disease in the lungs visible on chest X-rays
* Minimum weight 20 kg (44 lb)
* Adequate blood work
* 2-3 week washout from chemotherapy
* No metastatic disease anywhere besides the lungs
* No concurrent treatment with any immune modulatory drugs, including corticosteroids
* Pets must come to CSU for all visits related to the clinical trial

STUDY PROTOCOL:
* Dogs will receive an IV infusion of CAR T cells. The blood for this procedure will be drawn two weeks prior to administration, and dogs will be treated with bone marrow suppressing drugs (fludarabine and cyclophosphamide) for two consecutive days before the CAR T cells are given back
* Dogs will also be prescribed daily oral losartan and propranolol to start 2 weeks prior to CAR T administration and will receive these medications throughout the entire study
* Recheck visits will be required 1, 3, 7, 14, 28, and 60 days after CAR T cell infusion for an exam, diagnostics, and study blood collection
* The study is complete after the Day 60 visit

OWNER RESPONSIBILITIES:
* You are responsible for the initial exam fee and costs of diagnosing your pet’s tumor, and any other tests recommended by your pet’s oncologist
* You will also be responsible for the costs of all exam fees throughout the duration of the study
* You are expected to make and keep all appointments associated with the study
* You must be comfortable administering oral medications at home and keeping a record of drug administration and side effects

FINANCIAL INCENTIVES:
* Once your pet is enrolled, the study will cover all costs related to the clinical trial (including diagnostics, CAR T cell generation and infusion, and study blood collection and processing), other than recheck exam fees
* If your pet experiences any side effects related to the clinical trial procedures, the study will cover the costs to treat these up to $2,000
* Funds are available to pay for screening tests to determine eligibility, including blood and urine tests, blood pressure, and chest x-rays

If you have further questions about any of our clinical trials, please visit https://www.csuanimalcancercenter.org.

09/30/2025

May We Have Your Attention Please:

Meet Lucy! 🐾 Lucy was treated for a mast cell tumor of the left ear with conventionally fractionated radiation therapy (CFRT) by the expert PetCure Oncology Team Thrive Pet Healthcare Specialists - Hoffman Estates .

Isn’t she the cutest?!

Warmest Congratulations Lucy! 🎉