05/06/2026
The gut is the source of a lot of histamine issues, and I often show this picture when educating clients.
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TOP: when the gut microbiome is balanced, and there is no GI inflammation, the mast cells are behaving.
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BOTTOM: when the gut microbiome is imbalanced and the gut is inflamed, the mast cells release histamine and other inflammatory mediators, which inflames the vagus nerve (the red river on the bottom), which is in close proximity. In order to decrease histamine and mast cell activity, you have to balance the gut and decrease GI inflammation!