Jessi Grajczyk D.O.

Jessi Grajczyk D.O. Dr. Jessi Grajczyk D.O.

Physician & Women’s Health Expert
Double Board-Certified in OBGyn (FACOG) and Functional Medicine (IFMCP)
Functional Medicine practitioner focused on treating the underlying causes for sustainable healing and long-term wellbeing.

01/27/2026

Dr. Jessi on Hormone Replacement Therapy — Part 7

Hot flashes get all the attention—but they’re only part of the picture.

Perimenopause and menopause can show up as:
• mood changes
• poor sleep
• body aches
• vaginal dryness
• feeling “off” without a clear reason

The key isn’t guessing—it’s testing.
Urine hormone testing (like the DUTCH test) shows how your body is actually metabolizing hormones, not just what your levels are on paper.

That insight allows us to:
✔ personalize food and supplement support
✔ improve hormone safety
✔ tailor care to your unique biology

This is what individualized, functional medicine looks like—no one-size-fits-all hormone plans.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

PersonalizedCare Women’sHealth

01/25/2026

HRT Part 6 - What happens during perimenopause?

Perimenopause isn’t random — it’s hormonal chaos with a reason.

Progesterone and testosterone tend to steadily decline, while estrogen fluctuates up and down. That imbalance often leads to estrogen dominance, which explains why so many women experience:
• mood swings
• irregular or heavy periods
• unpredictable cycles
• feeling “hormonal” or unlike themselves

And here’s the key takeaway: perimenopause doesn’t have an age requirement.
Some women notice symptoms in their mid-30s, others closer to 50. It’s not about the number — it’s about the symptoms.

This is why having an informed conversation with a provider who understands hormone physiology matters. Early guidance = better outcomes.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

’sHealth FunctionalMedicine RootCauseCare

01/22/2026

Dr. Jessi on Hormone Replacement Therapy — Part 5

This is where timing becomes everything.

When estrogen is started too late, after many years without hormonal support, the risk profile changes. Women naturally experience heart disease later than men in part because estrogen is protective. But if hormone therapy is initiated around age 63—after more than a decade post-menopause—there may already be plaque buildup in the arteries, which can increase cardiovascular risk.

This insight from the WHI helped shape what we now understand:
👉 Hormone therapy works best when started earlier, closer to menopause or during perimenopause.

The goal isn’t fear—it’s personalized, informed care based on physiology and timing, not outdated one-size-fits-all conclusions.

If you’ve been confused by mixed messages about HRT, you’re not alone—and the science has evolved.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

’sHeartHealth FunctionalMedicine RootCauseHealing

01/21/2026

Hormone Replacement Therapy — Part 4

What we’ve learned since the WHI is this: many women in that study were started on hormones too late. Today, the data shows that beginning hormone replacement therapy earlier—during perimenopause, when symptoms start—leads to better outcomes and lower risk.

Hot flashes, sleep disruption, mood changes, brain fog, weight shifts—these aren’t signs to “just push through.” They’re signals. And when addressed at the right time, hormone therapy can be both protective and empowering.

The takeaway?
👉 Earlier, personalized hormone support = better long-term health.

If you’re experiencing perimenopausal symptoms and wondering when to start the conversation, now is a great time.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

FunctionalMedicine RootCauseHealing

01/20/2026

Hormone Replacement Therapy — Part 3

Not all hormones are created equal.

In this clip, Dr. Jessi breaks down one of the most important distinctions in HRT:
👉 Bioidentical vs. synthetic hormones

Bioidentical hormones mirror the estrogen and progesterone your body naturally makes—allowing for gentler, more physiologic support. Synthetic versions often contain additives and dyes that can increase inflammation and may carry higher risk.

This is why how and what you prescribe matters just as much as if you prescribe.
Hormone care should be evidence-based, individualized, and rooted in safety—not outdated fear.

If you’ve been told “HRT isn’t safe” but never learned the difference… this conversation is for you.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

’sHealth RootCauseHealing Perimenopause MenopauseCare

01/19/2026

If you feel confused about hormones… you’re not imagining it.

Many women receive conflicting advice from different providers—especially when it comes to hormone replacement therapy.

Some clinicians were trained on outdated data. Others are hesitant due to fear or lack of education. And the result? Women left unsure of who to trust.

You deserve clarity. You deserve evidence-based care. And you deserve a provider who takes the time to individualize your treatment.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

01/18/2026

✨ Dr. Jessi on HRT (part 1) ✨

Hormone Replacement Therapy (HRT) isn’t one-size-fits-all. It can include pills, patches, injections, or creams—and may use estrogen, progesterone, and/or testosterone, depending on your needs.

For years, the WHI (Women’s Health Initiative) study caused fear and hesitation around HRT. But what many don’t realize? That data was flawed—and it held women back from therapies that can be truly life-changing.

Today, evidence-based providers are helping set the record straight. When appropriately prescribed and individualized, HRT can support:
• Energy & mood
• Bone & heart health
• Brain function
• Metabolic and overall quality of life

💬 “My goal is to get the truth out there—so women can make informed, empowered decisions about their hormones.”

If you’ve been told HRT is “dangerous” or “not for you,” it may be time for a deeper conversation.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

Perimenopause MenopauseCare RootCauseHealing EvidenceBasedMedicine

01/15/2026

Elimination diet vs. food sensitivity testing — what’s the difference? 🤔🍽️

Dr. Jessi breaks it down
✨ An elimination diet is more general. We remove common triggers like gluten, dairy, eggs, soy, corn, and nightshades to see how your body responds overall.
✨ A food sensitivity test is personalized to you. It shows your specific reactions, but it does require commitment — removing flagged foods for 3 months if reactions are mild, or up to 6 months if they’re severe.
Both tools can be powerful — it’s all about finding what works best for your body.

🌐 Learn more or book at DrJessiDO.com
📍 Plymouth, MN | 📞 612-245-5665

01/14/2026

🐟 Autoimmune Q&A with Dr. Jessi 🐟

Are fish oil supplements necessary if you have an autoimmune condition?
👉 It depends.

If you’re eating clean, fresh-caught fish 3–4 times per week, you may not need additional fish oil. But for many people, that consistency is hard to maintain—especially at therapeutic omega levels.

✨ When supplementation is needed, quality matters:
• Choose clean, third-party tested brands
• Avoid farm-raised sources
• Look for low mercury and high omega content

One trusted option Dr. Jessi often recommends: Nordic Naturals

Omega-3s play a key role in reducing inflammation and supporting autoimmune balance, but not all supplements are created equal.

Have questions about your omega levels or whether you need supplementation?
🌐 Book a functional medicine visit at DrJessiDO.com
📍 Plymouth, MN | 📞 612-245-5665

RootCauseHealing InflammationSupport SupplementQuality IntegrativeHealth

01/10/2026

💚 Autoimmune Health: What the Data Actually Shows

In this interview, Dr. Jessi breaks down a few powerful (and often overlooked) factors that matter when it comes to autoimmune healing:

Connection matters
Research shows that being surrounded by loving, supportive people can help reduce autoimmune flares. Healing isn’t just biochemical—it’s relational, too.

What is LDN?
Low-dose naltrexone (LDN) has been shown to reduce the risk of future autoimmune disease progression by supporting immune regulation.

Why omega levels matter
• Omega-3 levels above 6 support heart health
• Levels above 8 are associated with reduced inflammation in autoimmune conditions

Key supplement for recovery
Magnesium glycinate—used in over 300 body systems—supports better sleep, reduces fatigue, and promotes nervous system balance.

Autoimmune care isn’t about one quick fix. It’s about addressing the whole picture—labs, lifestyle, connection, and targeted support.

🌐 Learn more or book at DrJessiDO.com
📍 Plymouth, MN | 📞 612-245-5665

Omega3 MagnesiumGlycinate InflammationSupport IntegrativeMedicine ChronicIllnessSupport

01/08/2026

🍵🔥 Morning routine, functional medicine style.

When you ask what Dr. Jessi does in the morning? She drinks her green tea and gets into the sauna at least twice a week. - And she says, “not only is it good for my thyroid, but it’s good for all of the cells in my entire body.”

This isn’t just a wellness trend—it’s science-backed self-care. Our Heavenly Heat infrared sauna uses advanced carbon heaters with low EMF, near-zero VOCs, and grounded technology to support true cellular healing.

✨ Why sauna is part of Dr. Jessi’s routine:
• Supports thyroid & metabolic health
• Improves cardiovascular function (linked to ↓ cardiac death risk)
• Encourages detox from heavy metals & mold
• Reduces inflammation & chronic pain
• Boosts skin health, circulation, and cellular repair

Sometimes the simplest habits make the biggest difference—when they’re done the right way.

🌐 Sauna sessions available at DrJessiDO.com
📞 612-245-5665

ThyroidSupport RootCauseHealing LowEMFSauna DetoxSupport WellnessHabits

01/07/2026

If you’re dragging through the day, gaining weight despite “doing everything right,” losing hair, or just feeling off—your thyroid may be asking for help.

Here’s the problem:
Most conventional practices only check TSH. But TSH is just the messenger from the brain. It doesn’t tell the full story.

At our clinic, we look deeper by testing:
✔️ TSH
✔️ Free T3 & Free T4
✔️ Reverse T3
✔️ Thyroid antibodies

Why this matters:
T4 must convert to T3—the active thyroid hormone that drives your energy, mood, metabolism, and weight. If that conversion is sluggish, or if antibodies are attacking the thyroid, symptoms can persist even when labs are called “normal.”

The functional medicine difference:
• No insurance restrictions
• Labs timed specifically to you and your medications
• Flexible lab locations
• A fully personalized plan created by a functional medicine–certified physician

If you’ve been told “everything looks fine” but don’t feel fine, it’s time for a deeper look.

Book at DrJessiDO.com
📍 Plymouth, MN | 📞 612-245-5665

HormoneHealth MetabolismSupport DrJessiDO IntegrativeMedicine

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Wayzata, MN
55391

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