01/21/2026
The Relationship Between Hashimoto’s Thyroiditis and Vitamin D Deficiency
By: Carol Kreider, MSN, APRN, FNP-C
Advanced Practice Registered Nurse
Hashimoto’s thyroiditis is the most common autoimmune cause of hypothyroidism worldwide. It occurs when the immune system mistakenly attacks the thyroid gland, leading to chronic inflammation and gradual loss of thyroid function. In recent years, growing attention has been given to the role of vitamin D in autoimmune diseases, particularly its relationship with Hashimoto’s thyroiditis. Research increasingly suggests that vitamin D deficiency is common among people with Hashimoto’s and may influence disease activity.
Vitamin D is traditionally known for its role in calcium absorption and bone health, but it also plays a critical role in immune system regulation. Numerous studies have found that individuals with Hashimoto’s thyroiditis tend to have lower vitamin D levels compared to healthy controls. Additionally, lower vitamin D levels have been associated with higher concentrations of thyroid antibodies, such as thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb). These antibodies are markers of autoimmune activity and play a role in the destruction of thyroid tissue. While this association does not prove causation, it highlights a meaningful link between vitamin D status and autoimmune thyroid disease.
One proposed explanation for this relationship lies in vitamin D’s effect on immune balance. In Hashimoto’s thyroiditis, this balance is disrupted, leading to chronic inflammation of the thyroid. Vitamin D deficiency may worsen this imbalance, contributing to increased immune aggression toward the thyroid gland.
Clinical trials examining vitamin D supplementation in people with Hashimoto’s have shown mixed but promising results. Some studies indicate that correcting vitamin D deficiency can lead to reductions in thyroid antibody levels, suggesting a dampening of autoimmune activity. However, supplementation does not consistently improve thyroid hormone levels or eliminate the need for thyroid hormone replacement therapy. This reinforces the idea that vitamin D is a supportive factor rather than treatment for Hashimoto’s.
It remains unclear whether vitamin D deficiency is a cause or a consequence of Hashimoto’s thyroiditis. Chronic inflammation may reduce vitamin D levels, while low vitamin D may predispose individuals to autoimmunity. Most experts agree the relationship is likely bidirectional, with each influencing the other over time.
From a practical standpoint, assessing vitamin D levels in individuals with Hashimoto’s thyroiditis is often recommended. When deficiency is identified, supplementation under medical guidance can be beneficial for overall health and may help support immune balance. However, vitamin D should be viewed as part of a comprehensive management plan that includes appropriate thyroid hormone replacement, regular monitoring, and attention to other nutritional and lifestyle factors.
In summary, vitamin D deficiency is common in Hashimoto’s thyroiditis and appears to be closely linked to immune dysfunction and disease activity. While it is not a cure, maintaining adequate vitamin D levels may play a supportive role in managing this complex autoimmune condition.
Please DO NOT start any supplementation without first discussing with your clinician.
