10/17/2019
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2019 NOBEL PRIZE IN PHYSIOLOGY
Just look š at this incredible clip showing how the entire abdominal & pelvic cavity moves with breathing! The quality of your breathing mechanics is far wider reaching than just your lungs. The diaphragm is a huge massaging muscle on the gut contents. Therefore, improving breathing mechanics & diaphragm function has the potential to improve digestive, renal, adrenal, liver, uterine, ovarian, pelvic floor, bowel & bladder function.
The 2019 Nobel Prize in physiology was awarded 4 days ago to William G. Kaelin Jr., Sir Peter J. Ratcliffe & Gregg L. Semenza for their newest discoveries that revealed the basis for our understanding of how O2 levels affect cellular metabolism & physiological function.
A practical application of this discovery includes breathing exercises that can improve oxygen levels (like the Wim Hof Method & yoga). It can now be explained how these techniques can impact anemia, cancer, stroke, infection, wound healing & myocardial infarctions!
For our science nerds, they discovered how the von Hippel-Lindau gene (VHL gene), a tumor suppressor gene, regulates a newly discovered complex that was named hypoxia-inducible factor (HIF). These findings wouldnāt have been possible without combining past discoveries:
The hormone erythropoietin & itās role in low oxygen states (recall that it helps create more RBCs!!); The 1931 Nobel Prize, revealed that oxygen is needed to turn food into useful energy via an enzymatic process;
The 1938 Nobel Prize, showed how blood oxygen sensing via the carotid body controls our respiratory rate by communicating directly with the brain; & the 2004 Nobel Prize in Chemistry that revealed the function of proteasomes!
This can also help us explain how oxygen sensing allows our cells to adapt their metabolism during intense exercise; how it generates new blood vessels & RBCs; & how our immune system uses O2! O2 sensing has even been shown to be essential during fetal development for controlling normal blood vessel formation & placenta development!
Take a deep breath fam, itās Friday!
Written by: Ā©āŖ10/11/2019⬠A