03/17/2026
🍀 Happy St. Patrick's Day.
I come from O'Sullivan stock. County Cork. Good people. Strong people. The kind who crossed an ocean and built something from nothing. I am proud of that blood.
The Irish gave the world great writers, great fighters, great craic, and a stubborn refusal to quit. They also gave their descendants something less celebrated. We call it the Celtic Curse.
What is it?
Hereditary hemochromatosis. The body absorbs too much iron. Not a little too much. Way too much. Over time that iron builds up in your liver, your heart, your joints, your pancreas. Left alone, it does real damage.
It is one of the most common genetic diseases in the United States, showing up in about 1 in 200 people with Caucasian ancestry, with roughly 1 in 10 being a carrier. Most have Celtic roots. Most have no idea.
Why the Irish?
The mutation is ancient. Researchers found it in 5,000-year-old human remains in Northern Ireland, carried by people who built megalithic monuments. It has been in Irish bones for a very long time.
Why did it spread?
Good question. One theory is that it gave an advantage when diets were iron-poor. Another is that it helped people shift from meat to grain. A third is that it may have helped fight parasites. Nobody knows for sure. What we do know is that it worked well enough to survive thousands of years of Irish history, including a famine that killed a million people.
Is there a benefit to being a carrier?
Maybe. Like sickle cell and malaria, or CF and cholera, the hemochromatosis gene may follow the same pattern. Nature trades one risk for another. Some research suggests carriers may have lower rates of atherosclerosis and better iron levels during growth and early adulthood. There is also interesting data showing a related variant appears more often in elite endurance athletes and is linked to higher aerobic capacity in male athletes. The full picture is still being worked out. But it is not crazy to think the Irish survived on that gene for a reason.
Watch for these symptoms
Fatigue. Joint pain. Brain fog. A bronze tinge to the skin in advanced cases. Symptoms often do not appear until around age 50 in men, and about a decade later in women, because menstruation naturally keeps iron levels lower. By then, damage can already be done.
Treatment is simple
You give blood. A pint is removed once a week, just like donating blood. It may take months to years of weekly phlebotomy to bring iron down to normal. Then it is done about four times a year to keep it there. Caught early, most people do very well and live a normal life.
Should you get tested?
If you have Irish, Scottish, Welsh, or broader Northern European ancestry, yes. A simple blood test checks iron and ferritin levels. Family members of anyone diagnosed should be tested too.
Come talk to me. This is exactly the kind of thing I am here for.
For more, read this AAFP patient guide on hereditary hemochromatosis: https://www.aafp.org/pubs/afp/issues/2002/0301/p865.html
📲 Text me at 540-406-8688 with questions, or enroll at https://paladinfamilypractice.com/patient-signup/
This post is for educational purposes only and does not constitute medical advice. Talk to your doctor before making any decisions about testing or treatment.